Search results for "FAS"
showing 10 items of 2015 documents
Resistance to Gemcitabine in a Lymphoma Cell Line Resistant to Fas-mediated Apoptosis
2004
BACKGROUND: The T-cell lymphoma cell line HuT78B1, selected for resistance to Fas-mediated apoptosis, resulted unexpectedly resistant to the apoptotic and cytotoxic effects of gemcitabine (dFdC). We investigated whether this resistance was due to the impairment of the Fas/Fas-ligand (FasL) system. MATERIALS AND METHODS: dFdC effects were studied in HuT78B1 and in the parental Fas-sensitive HuT78 cells exposed to inhibitors of the Fas/FasL system. RESULTS: FasL- and Fas-blocking antibodies did not interfere with dFdC-induced apoptosis in HuT78 cells, whereas inhibitors of caspase-8, -9, -1 or -3 had partial inhibitory effects. Notably, in HuT78B1 cells there was a markedly reduced dFdC accum…
Surgical anatomy of the upper esophagus related to robot-assisted cervical esophagectomy
2021
Abstract Robot-assisted cervical esophagectomy (RACE) enables radical surgery for tumors of the middle and upper esophagus, avoiding a transthoracic approach. However, the cervical access, narrow working space, and complex topographic anatomy make this procedure particularly demanding. Our study offers a stepwise description of appropriate dissection planes and anatomical landmarks to facilitate RACE. Macroscopic dissections were performed on formaldehyde-fixed body donors (three females, three males), according to the surgical steps during RACE. The topographic anatomy and surgically relevant structures related to the cervical access route to the esophagus were described and illustrated, a…
Influence of microsomal triglyceride transfer protein promoter polymorphism -493 GT on fasting plasma triglyceride values and interaction with treatm…
2005
Familial hypercholesterolaemia (FH) is an autosomal dominant disease characterized by elevated levels of low-density lipoprotein-cholesterol (LDL-C). Phenotypic expression is highly variable, being influenced by diet, age, gender, body mass index, apolipoprotein E genotype and type of LDL-receptor gene mutation. Microsomal triglyceride (TG) transfer protein (MTP) is a protein involved in lipid metabolism. Polymorphism MTP -493 GT has been shown to modulate lipid levels in several populations. To analyse the effect of this polymorphism in the lipid phenotype expression of FH and treatment response, we studied a sample of 222 Spanish FH patients, of whom 147 were studied before and after trea…
Polychromatic femtosecond fluorescence studies of metal–polypyridine complexes in solution
2011
Femtosecond-resolved broadband fluorescence studies are reported for[ M(bpy)(3)](2+) (M = Fe, Ru), RuN3 and RuN719 complexes in solution. We investigated the pump wavelength dependence of the fluorescence of aqueous [ Fe(bpy)(3)](2+) and the solvent and ligand dependence of the fluorescence of Ru-complexes excited at 400 nm. For all complexes, the (MLCT)-M-1 fluorescence appears at zero time delay with a mirror-like image with respect to the absorption. It decays in <= 30-45 fs due to intersystem crossing to the (MLCT)-M-3 states, but a longer lived component of similar to 190 fs additionally shows up in RuN719 and RuN3. No solvent effects are detected. The very early dynamics are character…
Sexual advertisement and immune function in an arachnid species (Lycosidae)
2004
A simple version of the immunocompetence handicap hypothesizes that through condition-dependence, the size of the sexual trait may be positively related to immune function at the population level. In the present study, we investigated the relationship between sexual advertisement and immune function in a natural population of male wolf spiders, Hygrolycosa rubrofasciata (Araneae: Lycosidae). Males of H. rubrofasciata have a costly and condition-dependent acoustic signal, courtship drumming. In the mating season, males drum against dry leaves while wandering around the habitat searching for receptive females. Males increase their mating success by increasing their drumming rate and mobility.…
Subglacial bed deformation and dynamics of the Apriķi glacial tongue, W Latvia
2011
Saks, T., Kalvans, A. & Zelcs, V. 2012 (January): Subglacial bed deformation and dynamics of the Apriķi glacial tongue, W Latvia. Boreas, Vol. 41, pp. 124–140. 10.1111/j.1502-3885.2011.00222.x. ISSN 0300-9483. We evaluate the glacial dynamics and subglacial processes of the Apriķi glacial tongue in western Latvia during the Northern Lithuanian (Linkuva) oscillation of the last Scandinavian glaciation. The spatial arrangement of glacial bedforms and deformation structures are used to reconstruct the ice dynamics in the study area. The relationship between geological structures at the glacier bed and the spatial distribution of drumlins and glacigenic diapirs, on the one hand, and the permeab…
Mediterranean Great Conversation
2015
The exit from the Mediterranean emergency requires rethinking its identity in a new perspective. This means recognizing its legitimate role as a “Great Sea in Between”, as a cultural interface able to connect all the citizens that address to it, in everyday life and as individuals, involving them in a real “great conversation” based on the design disciplines. Design, Brand, Visual Identity, Packaging, Social Media, Fashion, Food, Architecture, Music may be powerful antidotes to the immobility of those who mourn a lost Mediterranean harmony and also a viable alternative to the ethnic closure led by the proponents of the Clash of Civilizations.
Disegno e analisi grafica Piano Regolatore Generale per la città di Tirana G. Bosio con I. Lambertini, 1939-1941. In La nuova immagine della città it…
2014
L'analisi e restituzione grafica del particolare del progetto di sistemazione Analisi e ricostruzione grafica del sistema urbano e delle relazioni assiali del Piazzale del Littorio dell'asse urbano del viale dell'Impero per il Piano Regolatore Generale per la città di Tirana, G. Bosio con I. Lambertini, 1939-1941 pubblicato nel Volume di Ettore Sess, La nuova immagine della città italiana nel ventennio fascista, Flaccovio Editore, 2014, di Ettore Sessa, analizza e restituisce attraverso lo strumento del diagramma grafico e concettuale i rapporti gerarchici, geometrici e formali tra architettura e città nel progetto di G. Bosio per il P.R. G. di Tirana del 1939-1941, traducendo in forma graf…
Space charge and induced dipole relaxation in solid electrolytes
1996
The space charge relaxation and induced dipole relaxation in solid electrolytes is discussed. The di-electric responses of these relaxations gives a satisfactory fit to the universal conductivity behaviours in the frequency range from DC to infrared.
Comparing the effects of introduced signal crayfish and native noble crayfish on the littoral invertebrate assemblages of boreal lakes
2015
The introduced North American signal crayfish Pacifastacus leniusculus (Dana) has replaced the native noble crayfish (Astacus astacus) in many European freshwaters and can be considered a new component of these ecosystems. The 2 species are apparently similar in many respects, but their ecological equivalence is uncertain and has been little investigated, especially at the whole-lake scale. We compared the effects of the 2 species on the abundance, species richness, and composition of littoral macroinvertebrate assemblages in a set of small- and mediumsized boreal lakes, which included 8 lakes with noble crayfish, 8 lakes with signal crayfish, and 8 lakes without crayfish. We collected semi…