Search results for "FATE"
showing 10 items of 765 documents
Proton-irradiated breast cells: molecular points of view
2019
Abstract Breast cancer (BC) is the most common cancer in women, highly heterogeneous at both the clinical and molecular level. Radiation therapy (RT) represents an efficient modality to treat localized tumor in BC care, although the choice of a unique treatment plan for all BC patients, including RT, may not be the best option. Technological advances in RT are evolving with the use of charged particle beams (i.e. protons) which, due to a more localized delivery of the radiation dose, reduce the dose administered to the heart compared with conventional RT. However, few data regarding proton-induced molecular changes are currently available. The aim of this study was to investigate and descri…
Structural organization of surfactant aggregates in vacuo: a molecular dynamics and well-tempered metadynamics study
2015
Experimental investigations using mass spectrometry have established that surfactant molecules are able to form aggregates in the gas phase. However, there is no general consensus on the organization of these aggregates and how it depends on the aggregation number and surfactant molecular structure. In the present paper we investigate the structural organization of some surfactants in vacuo by molecular dynamics and well-tempered metadynamics simulations to widely explore the space of their possible conformations in vacuo. To study how the specific molecular features of such compounds affect their organization, we have considered as paradigmatic surfactants, the anionic single-chain sodium …
Hydrolysis of (CH3)Hg+ in Different Ionic Media: Salt Effects and Complex Formation
1998
The hydrolysis of monomethylmercury(II) was studied potentiometrically, in NaNO3, Na2SO4, and NaCl aqueous solution, in a wide range of ionic strengths (NaNO3, 0 ≤ I ≤ 3.25; Na2SO4, 0 ≤ I ≤ 1; NaCl, 0 ≤ I ≤ 3 mol dm-3) and at t = 25 °C. For the reaction (CH3)Hg+ = (CH3)Hg(OH)° + H+, we found log K1 = −4.528 (I = 0 mol dm-3). The species [(CH3)Hg]2(OH)+ was also found, with log β2 = −2.15. Monomethylmercury(II) forms quite strong complexes with Cl- (log K = 5.45, I = 0 mol dm-3) and SO42- (log K = 2.64, I = 0 mol dm-3). The dependence on ionic strength of formation constants was considered by using a Debye−Huckel type equation. Hydrolysis and complex formation constants (at different ionic s…
Viscosimetric investigation of the interaction between sodium dodecylsulfate micelles and a polymer drug carrier
1993
Abstract The viscosities of aqueous sodium dodecyl sulfate solutions with and without α,β-poly( N -hydroxyethyl)- dl -aspartamide (PHEA), at 15, 25 and 35°C are reported. The viscosities of SDS and of PHEA aqueous solutions are discussed in terms of the parameter D [D = ( η η 0 − 1)/φ] describing the non-ideal behavior of SDS micelles and of PHEA macromolecules. The viscosities of SDS plus PHEA aqueous solutions, discussed in terms of the parameter F [ F = η rel ( PHEA ) + η rel ( SDS ) − η rel ( SDS + PHEA )] M , demonstrate the occurrence of interactions between SDS micelles and the PHEA macromolecule. Both D and F are scarcely influenced by temperature variation.
Adsorption of triblock copolymers and their homopolymers at laponite clay/solution interface. Role played by the copolymer nature
2009
The adsorption thermodynamics of copolymers, based on ethylene oxide (EO) and propylene oxide ( PO) units, at the laponite (RD) clay/liquid interface was determined at 298 K. The copolymer nature was tuned at molecular level by changing the hydrophilicity, the architecture and the molecular weight (Mw) keeping constant the EO/PO ratio. Polyethylene (PEGs) and polypropylene (PPGs) glycols with varying Mw and their mixture were also investigated to discriminate the role of the EO and the PO segments in the adsorption process. Enthalpies of transfer of RD, at fixed concentration, from water to the aqueous macromolecule solutions as functions of the macromolecule molality were determined. They …
Separation of homologues and isomers of linear alkylbenzenesulfonates by capillary electrophoresis with sodium dodecyl sulfate, carboxylic acids and …
2003
The ability of several anionic compounds, including carboxylic and dicarboxylic acids, sodium dodecyl sulfate (SDS), and sodium deoxycholate (SDC) and other bile salts, to separate the C(10)-C(13) homologues and the corresponding 20 positional isomers of linear alkylbenzenesulfonates (LAS) by capillary electrophoresis was studied. Up to 19 peaks and a shoulder were observed with a background electrolyte (BGE) containing 10 mM phosphate (pH 6.8), 30% acetonitrile and 40 mM SDS, and 18 peaks were obtained with a BGE containing 10 mM borate (pH 9), 40% ethanol and 40 mM palmitic acid (PA). Resolution increased with the alkyl chain length of the carboxylic acid. Dicarboxylic acids with a short …
Cationic and Zwitterionic Polymerizable SurfactantsQuaternary Ammonium Dialkyl Maleates. 2. Emulsion Polymerization of Styrene and Butyl Acrylate
1998
Polymerizable cationic and zwitterionic dialkyl maleates with different hydrophobic chain lengths (R = C10H21, C12H25, C16H33, C18H37) and different counterions (I, Br, HSO4) for the cationic hydrophilic part, as well as some similar surfactants, dialkyl succinates, were used in batch and seeded emulsion polymerization of styrene and butyl acrylate. All surfactants, when used in emulsion polymerization, provide good stability to the styrene/butyl acrylate latices. A styrene/butyl acrylate latex prepared with sodium dodecyl sulfate (SDS) was used as a reference. Some stability tests for latices were performed, and the glass transition temperatures, as well as the molecular weights of the pol…
Increased sulfate availability in saline water promotes hydrogen sulfide production in fish organic waste
2020
The risk of hydrogen sulfide (H2S) production can be a challenge in marine land-based recirculating aquaculture systems (RAS). Hydrogen sulfide is a toxic gas that can cause massive fish mortality even at low concentrations, and in addition, serious odour problems in the surroundings. It is a bacterial by-product originating from the degradation of organic matter in sulfur-rich waters such as marine waters. In order to hinder H2S production in marine land-based RAS, more information on the H2S production conditions and the associated microbiology is needed. In this study, the production of H2S from rainbow trout (Oncorhynchus mykiss) organic waste was examined using a novel H2S measurement …
The second component of human complement: Detection of two hemolytic forms in plasma by pH Variation
1988
The second component of human complement (C2) in pseudoglobulin prepared from normal plasma eluted as a single peak at high conductivity (30 mS) and pH 4.5 from the cationic exchangers S-Sepharose or Mono S in the Fast Protein Liquid Chromatography (FPLC) System. The C2 was stable at pH 4.5 and 0 degrees C if enzyme inhibitors were used and the pH was raised to 6.0 after elution from the columns. After rechromatography on Mono S in the FPLC System at the median isoelectric point of 5.5 or pH 6.0, the C2 eluted as two distinct hemolytic forms: the first peaked at 16 mS, the second at 30 mS. The two forms of C2 did not correlate with the allotypic variant of C2 in individual, normal human pla…
Physicochemical compatibility of nebuliser solution admixtures containing colistimethate and hypertonic saline or colistimethate, fluticasone-17-prop…
2012
Objectives For practical reasons, patients with cystic fibrosis (CF) tend to mix different inhalation solutions for concomitant inhalation instead of inhaling the different medications consecutively. A study was undertaken to examine the compatibility of colistimethate dissolved in 5.85% hypertonic sodium chloride (NaCl) solution and the quadripartite mixtures of colistimethate, fluticasone-17-propionate, ipratropium bromide and salbutamol sulfate. Methods The test solutions were prepared by mixing ordinary doses of the inhalation products and analysed immediately. Microbiological assays of antibiotics and high-performance liquid chromatography assays were used to determine chemical compati…