Search results for "FATE"

showing 10 items of 765 documents

Ovarian and Adrenal Hyperandrogenism

2007

Because in normal women androgens are secreted in almost equal quantities by both adrenals and ovaries, for many years many studies have tried to distinguish the source of androgen excess. However, in the last 10-15 years, the diagnoses of ovarian or adrenal hyperandrogenism have almost disappeared. This is due to the lack of specificity of dynamic tests as well as to the emphasis given on clinical information and ovarian sonography for the diagnosis of hyperandrogenic syndromes. However, determination of the source of increased androgens may still be useful for improving the classification and the understanding of androgen excess disorders. The aim of this review is to examine the source o…

medicine.medical_specialtymedicine.drug_classidiopathic hyperandrogenismOvaryurologic and male genital diseasesAndrogen ExcessGeneral Biochemistry Genetics and Molecular Biologychemistry.chemical_compoundDehydroepiandrosterone sulfateNCAHHistory and Philosophy of ScienceInternal medicineAdrenal GlandsPCOSmedicineHyperinsulinemiaHumansbusiness.industryGeneral NeuroscienceOvaryHyperandrogenismnonclassic 21-hydroxylase deficiencymedicine.diseaseAndrogenPolycystic ovaryAndrogen secretionEndocrinologymedicine.anatomical_structurechemistryFemaleSteroid 21-Hydroxylaseandrogen excessHyperandrogenismbusinessPolycystic Ovary SyndromeAnnals of the New York Academy of Sciences
researchProduct

Intravenous SPION-labeled adipocyte-derived stem cells targeted to the brain by magnetic attraction in a rat stroke model: An ultrastructural insight…

2021

Abstract Mesenchymal stem cell therapy after stroke is a promising option investigated in animal models and clinical trials. The intravenous route is commonly used in clinical settings guaranteeing an adequate safety profile although low yields of engraftment. In this report, rats subjected to ischemic stroke were injected with adipose-derived stem cells (ADSCs) labeled with superparamagnetic iron oxide nanoparticles (SPIONs) applying an external magnetic field in the skull to retain the cells. Although most published studies demonstrate viability of ADSCs, only a few have used ultrastructural techniques. In our study, the application of a local magnetic force resulted in a tendency for hig…

medicine.medical_treatmentBiomedical EngineeringPharmaceutical ScienceMedicine (miscellaneous)BioengineeringCell fate determinationCorrelative microscopy Electron microscopy Magnetic fields SPION Stem cell therapy Strokechemistry.chemical_compoundAdipocyteAdipocytesmedicineAnimalsGeneral Materials ScienceMagnetite NanoparticlesStrokeMicrogliaStem CellsMesenchymal stem cellBrainStem-cell therapymedicine.diseaseMagnetic Resonance ImagingRatsCell biologyStrokeMagnetic Fieldsmedicine.anatomical_structurechemistryUltrastructureMolecular MedicineStem cellNanomedicine: Nanotechnology, Biology and Medicine
researchProduct

Spontaneous labour at term is associated with fetal monocyte activation.

1999

SUMMARYThe aetiology of both term and preterm labour remains incompletely understood. Maternal infectious diseases as well as intra-uterine infections were shown to be a well established cause of uncontrollable preterm delivery, indicating that inflammatory reactions, regulated by maternal immunecompetent cells, are implicated in labour-promoting mechanisms. To investigate the possibility that the activation of the fetal immune system may be involved in labour induction, we examined cytokine production patterns of different cord blood cell populations obtained from neonates after spontaneous onset of normal term labour and vaginal delivery (n = 25), vaginal delivery but induced term labour …

medicine.medical_treatmentT cellImmunologyInflammationGestational AgeBetamethasoneMonocytesMagnesium SulfateImmune systemFetusObstetric Labor PrematurePregnancymedicineImmunology and AllergyHumansLabor InducedLungreproductive and urinary physiologyFenoterolFetusLabor Obstetricbusiness.industryVaginal deliveryCesarean SectionInterleukin-6MonocyteInfant NewbornDelivery ObstetricFetal Bloodmedicine.anatomical_structureCytokineTocolytic AgentsCord bloodImmunologyFemaleOriginal Articlemedicine.symptombusinessClinical and experimental immunology
researchProduct

High-performance liquid chromatographic determination of diuretics in urine by micellar liquid chromatography.

1992

The use of micellar liquid chromatography for the determination of diuretics in urine by direct injection of the sample into the chromatographic system is discussed. The retention of the urine matrix at the beginning of the chromatograms was observed for different sodium dodecyl sulphate (SDS) mobile phases. The eluent strengths of a hybrid SDS-methanol micellar mobile phase for several diuretics were compared and related to the stationary phase/water partition coefficient with a purely micellar mobile phase. The urine band was appreciably narrower with a mobile phase of 0.05 M SDS-5% methanol (v/v) at 50 degrees C (pH 6.9). With this mobile phase the determination of bendroflumethiazide an…

medicine.medical_treatmentUrineHigh-performance liquid chromatographyMatrix (chemical analysis)Column chromatographyHydrochlorothiazideFurosemidemedicineHumansDiureticsChromatography High Pressure LiquidMicellesTriamtereneChromatographyChemistryProbenecidSodium Dodecyl SulfateGeneral ChemistryChlorothiazideAcetazolamideEthacrynic AcidHydrochlorothiazideMicellar liquid chromatographyBendroflumethiazideDiureticmedicine.drugChromatography LiquidJournal of chromatography
researchProduct

Kinetic properties of catecholoxidase activity of tarantula hemocyanin

2008

Phenoloxidases occur in almost all organisms, being essentially involved in various processes such as the immune response, wound healing, pigmentation and sclerotization in arthropods. Many hemocyanins are also capable of phenoloxidase activity after activation. Notably, in chelicerates, a phenoloxidase has not been identified in the hemolymph, and thus hemocyanin is assumed to be the physiological phenoloxidase in these animals. Although phenoloxidase activity has been shown for hemocyanin from several chelicerate species, a characterization of the enzymatic properties is still lacking. In this article, the enzymatic properties of activated hemocyanin from the tarantula Eurypelma californi…

medicine.medical_treatmentchemical and pharmacologic phenomenaBiologyBiochemistrySubstrate Specificitychemistry.chemical_compoundDopamineHemolymphmedicineAnimalsMolecular Biologychemistry.chemical_classificationSodium Dodecyl SulfateSubstrate (chemistry)Spidershemic and immune systemsHemocyaninCell BiologyTyramineEnzyme ActivationKineticsEnzymechemistryBiochemistryHemocyaninsAzideKojic acidCatechol Oxidasemedicine.drugThe FEBS Journal
researchProduct

Increased sulfate availability in saline water promotes hydrogen sulfide production in fish organic waste

2020

The risk of hydrogen sulfide (H2S) production can be a challenge in marine land-based recirculating aquaculture systems (RAS). Hydrogen sulfide is a toxic gas that can cause massive fish mortality even at low concentrations, and in addition, serious odour problems in the surroundings. It is a bacterial by-product originating from the degradation of organic matter in sulfur-rich waters such as marine waters. In order to hinder H2S production in marine land-based RAS, more information on the H2S production conditions and the associated microbiology is needed. In this study, the production of H2S from rainbow trout (Oncorhynchus mykiss) organic waste was examined using a novel H2S measurement …

merivesisulfate reducing bacteriasulfaatitrikkivetyhydrogen sulfidesulfateorgaaninen ainesequipment and suppliesorganic matterseawater
researchProduct

Micelles in Mixtures of Sodium Dodecyl Sulfate and a Bolaform Surfactant

2006

Mixtures composed of water, sodium dodecyl sulfate (SDS), and a bolaform surfactant with two aza-crown ethers as polar headgroups (termed Bola C-16) were investigated by modulating the mole ratios between the components. The two surfactants have ionic and nonionic, but ionizable, headgroups, respectively. The ionization is due to the complexation of alkali ions by the aza-crown ether unit(s). Structural, thermodynamic, and transport properties of the above mixtures were investigated. Results from surface tension, translational self-diffusion, and small angle neutron scattering ( SANS) are reported and discussed. Interactions between the two surfactants to form mixed micelles result in a com…

mixed micellesIonic bondingEtherANGLE NEUTRON-SCATTERINGMicelleanionic surfactants; mixed micelles; neutron scatteringSurface tensionSurface-Active Agentschemistry.chemical_compoundPulmonary surfactantAQUEOUS-SOLUTIONSSodium sulfateanionic surfactantsElectrochemistrySurface TensionGeneral Materials ScienceSodium dodecyl sulfateSANS surfactant mixtures micellesMicellesSpectroscopyHYDROCARBON SURFACTANTSPHASE SEPARATION MODELChromatographyneutron scatteringSodium Dodecyl SulfateSurfaces and InterfacesCondensed Matter PhysicsSmall-angle neutron scatteringchemistryChemical engineeringLangmuir
researchProduct

Digital control circuitry for the p53 dynamics in cancer cell and apoptosis

2010

Abstract Experimental work and theoretical models deduce a “digital” response of the p53 transcription factor when genomic integrity is damaged. The mutual influence of p53 and its antagonist, the Mdm2 oncogene, is closed in a feedback. This paper proposes an aerospace-based architecture for translating the p53/Mdm2/DNA damage network into a digital circuitry in which the optimal control theory is applied for obtaining the requested dynamic evolutions of some considered cell species for repairing a DNA damage. The purpose of this paper is to demonstrate the usefulness of such digital circuitry design to detect and predict the cell species dynamics for shedding light on their inner and mutua…

p53General Immunology and MicrobiologyMechanism (biology)DNA damageQH301-705.5General NeuroscienceapoptosisWiring diagramCell fate determinationBiologycellular circuitryBioinformaticsOptimal controlGeneral Biochemistry Genetics and Molecular Biologyprotein networks signallingfeedback controlCancer cellDigital controlBiology (General)General Agricultural and Biological SciencesBiological systemTranscription factorOpen Life Sciences
researchProduct

Party autonomy regarding jurisdiction under the property regimes regulations

2021

The main accomplishment of the Property Regimes Regulations lies in their bringing more coherence into the cross-border family law adjudication. In the field of international jurisdiction, they strive to align the competence in couples? patrimony disputes to that in succession and in separation proceedings, or else to align the competence of the courts to the applicable law. These tendencies are clearly visible in the Regulations? provisions on choice of court agreements. Namely, the Regulations allow for such agreements, but severely limit parties? choice and the possible effects of these clauses. When succession or separation proceedings are pending, it is often only possible to institute…

party autonomy.registered couples? propertyit is often only possible to institute patrimonial disputes at the same court as the said proceedings. When proceedings concerning matrimonial or registered partners? property are initiated without previously pending succession or divorce proceedingshoweveror else to align the competence of the courts to the applicable law. These tendencies are clearly visible in the Regulations? provisions on choice of court agreements. Namelyanalogy with other EU regulations and the CJEU case-law can be of help. The critical eye of the doctrine isrégimen económico-matrimonialRegulation 1104/2016mainly cast on the unpredictable fate of the choice of court agreements under the Regulations. The paper analyses the complex regulation of the choice-ofcourt agreements in the Property Regimes Regulationsautonomía de parte. 274 291draws attention to open questions and provides possible answers. Choice-of-court agreementjurisdictionmatrimonial propertybut severely limit parties? choice and the possible effects of these clauses. When succession or separation proceedings are pendingthey strive to align the competence in couples? patrimony disputes to that in succession and in separation proceedings:CIENCIAS JURÍDICAS [UNESCO]parties can avail themselves of a fairly limited list of options to choose a court from. The Regulations leave several questions regarding choice of court agreements unanswered. Oftenjurisdicciónthe Regulations allow for such agreementsAcuerdo de elección del fororégimen de parejas registradasor else when the necessary consent to the joinder is not given2386-4567 22661 Actualidad jurídica iberoamericana 587897 2021 15 8113562 Party autonomy regarding jurisdiction under the property regimes regulations Kramberger ?kerlJerca The main accomplishment of the Property Regimes Regulations lies in their bringing more coherence into the cross-border family law adjudication. In the field of international jurisdictionReglamento 1103/2016UNESCO::CIENCIAS JURÍDICASRegulation 1103/2016Reglamento 1104/2016
researchProduct

Guano-related phosphate-rich minerals in European caves

2019

International audience; Guano is a typical deposit found in caves derived from the excretions of bats and in minor cases of birds. These organic deposits decompose and form a series of acid fluids and gases that can interact with the minerals, sediments, and rocks present in the cave. Over sixty phosphates are known and described from caves, but guano decay also often leads to the formation of nitrates and sulfates. In this study twenty-two European caves were investigated for their guano-related secondary minerals. Using various analytical techniques, seventeen phosphates, along with one sulfate (gypsum), were recognized as secondary products of guano decay. Among those minerals, some are …

phosphatesGypsum010504 meteorology & atmospheric sciencesQH301-705.5Settore GEO/04 - Geografia Fisica E GeomorfologiaGeochemistrybat guanocave minerals phosphate bat guanoengineering.material010502 geochemistry & geophysics01 natural sciencessecondary cave mineralsApatitechemistry.chemical_compoundCavesecondary cave minerals phosphates minerogenesis limestone caves bat guanominerogenesisBiology (General)Sulfatelimestone cavephosphate0105 earth and related environmental sciencesEarth-Surface Processescave mineralsQE1-996.5geographygeography.geographical_feature_categoryMineralSettore GEO/07 - Petrologia E PetrografiaGeology15. Life on landPhosphatehumanitiessecondary cave mineralchemistryminerogenesivisual_artlimestone cavesGuanoengineeringvisual_art.visual_art_mediumPyrite[SDU.STU.MI]Sciences of the Universe [physics]/Earth Sciences/Mineralogy
researchProduct