Search results for "FD"
showing 10 items of 483 documents
016: Evidence of systemic plaque vulnerability in acute coronary syndromes with FDG-positron emission tomography and computed tomographic angiography…
2013
PurposeAtherosclerotic plaque vulnerability is a systemic phenomenon and is often associated with severe plaque infiltration with inflammatory cells. 18-Fluoro-deoxyglucose (FDG) accumulates in inflammatory cells of atherosclerotic plaques. The aim of this study was to assess whether 1) FDG uptake in the aorta and carotid arteries measured by positron emission tomography (PET) is higher in patients with acute coronary syndromes (ACS) than in patients with stable coronary artery disease (CAD) and; 2) associated with morphological markers of plaque instability detected with computed tomography angiography (CTA).MethodsPatients with ACS (n=50) or stable CAD (n=28) underwent a PET 90 minutes af…
18F-FDG PET/CT in cardiovascular infection and inflammation.
2021
The diagnosis of cardiovascular infection and inflammation by [18F]FDG PET/CT in Nuclear Cardiology is of growing interest, because with respect to echocardiography this technique has improved the certainty in the diagnosis of infective endocarditis in patients with prosthetic valves, the increasing number of patients with implantable cardiac devices because of the progressive ageing of the population, as well as in patients with suspected large vessel vasculitis. All are serious clinical situations which require correct diagnosis and appropriate treatment as soon as possible, because they can cause severe complications, high mortality and also increased health care costs. We review the use…
Teaching Technology Usage in the ENT Medical Subdomain via a Flipped Classroom Approach
2018
The flipped classroom approach is supporting a continuous interaction of students and instructors via online communication and strengthens the ability to solve problems by self-organization. This is especially important in medical domains, like the one of ENT-Head/Neck (ENT: Ear-Nose-Throat) surgeries and treatment. Surgical corrections of the nasal airways, like FESS (Functional Endoscopy Sinus Surgery) or in the field of plastic surgery, are the second frequent surgical interventions in otorhinolaryngology. They have to be prepared very carefully and airflow simulation with Computational Fluid Dynamics (CFD) is gaining importance for diagnostics here. New in silico procedures, like imagin…
Role of fluorine 18 fluorodeoxyglucose positron emission tomography/computed tomography in gastrointestinal cancers
2015
AbstractFluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) has become a routine imaging modality for many malignancies and its use is currently increasing. In the present review article, we will summarize the evidence for FDG-PET/CT use in digestive cancers (excluding neuroendocrine tumours), and review the existing recommendations. While PET/CT is nowadays considered to be an important tool in the initial workup of oesophageal and anal cancers, new data are emerging regarding its use in assessing therapeutic efficacy, radiotherapy treatment planning, and detection of recurrence in case of isolated tumour marker elevation. Moreover, PET/CT may help …
Multiparametric 18F-FDG PET-MRI of the breast: are there differences in imaging biomarkers of contralateral healthy tissue between patients with and …
2019
The rationale was to assess whether there are differences in multiparametric 18F-FDG PET/MRI biomarkers of contralateral healthy breast tissue in patients with benign and malignant breast tumors. Methods: In this institutional review board-approved prospective single-institution study, 141 women with imaging abnormalities on mammography or sonography (BI-RADS 4/5) underwent combined 18F-FDG PET/MRI of the breast at 3T with dynamic contrast-enhanced MRI, diffusion-weighted imaging, and the radiotracer 18F-FDG. In all patients, the following imaging biomarkers were recorded for the contralateral (tumor-free) breast: breast parenchymal uptake (BPU) (from 18F-FDG PET), mean apparent diffusion c…
Stereotactic body radiation therapy for liver oligometastases: predictive factors of local response by 18F-FDG-PET/CT
2018
Objective:To investigate metabolic parameters as predictive of local response after stereotactic body radiation therapy (SBRT) for liver-oligometastases.Methods:Inclusion criteria of the present re...
Glucagon-like peptide-2 analog and inflammatory state in obese mice
2020
Obesity is characterized by chronic low grade of systemic inflammation that develops in response to nutrient excess and plays a key role in the pathogenesis of insulin resistance. It is characterized by macrophage infiltration into adipose tissue (AT) and abnormal cytokine production. These factors damage the metabolic homeostasis leading to alteration in the insulin signaling in specific tissues and organs such as AT and liver. Thus, obese subjects develop over the time resistance to the cellular actions of insulin. Glucagon like peptide-2 (GLP-2) is an intestinal proglucagon-derived hormone released together with GLP1, in response to the passage of food by the distal small intestine. Once…
Prognostic Value of Radiomics Signature By Diagnostic 18F-FDG PET/CT Analysis in Aggressive Non-Hodgkin's Lymphoma
2018
Abstract BACKGROUND Although the overall prognosis of patients with aggressive non-Hodgkin's lymphoma (NHL) has improved, nearly a third of patients will have refractory disease or relapse. Identification of these high-risk patients using traditional prognostic factors is limited. PET is the recommended imaging modality for the staging of FDG-avid lymphoma but the value of a comprehensive new imaging biomarkers analysis applied to PET for the prediction of patients outcome has still not been deeply investigated. New metrics estimating the overall tumor burden such as metabolic tumor volume (MTV) and those that may capture intratumoral biological heterogeneity such as total lesion glycolysis…
Ārpusšūnu cirkulējošo nukleīnskābju izpēte hipofīzes adenomas pacientos
2019
Līdz šim literatūrā nav ziņojumu par ccfDNA un cirkulējošo miRNS izpēti HA pacientu plazmā. Darbā tika novērtēta iespējamība detektēt HA izcelsmes ccfDNA plazmā, veicot mērķētu NGS pozīcijās, kuras saturēja HA somatiskās mutācijas, un veikts pētījums par miRNS sastāva izmaiņu detektēšanu plazmā 24 stundas pēc HA rezekcijas. HA eksomos atklātās somatiskās mutācijas tikai detektētas septiņās no 16 pārbaudītajām pozīcijām ccfDNA amplikonos. Divās ccfDNA pozīcijās mutantā alēle bija vairāk nekā 2% no kopējā nolasījumu skaita, kas varētu liecināt par šo ccfDNA izcelsmi no HA. Piecās pozīcijās no diviem HA pacientiem mutantās alēles īpatsvars ccfDNA bija ap 50%, kaut gan šīs mutācijas netika kons…
Analiza sposobów modelowania reaktora trójfazowego ze stałym złożem (TBR) z użyciem metod CFD
2018
Przedstawiono zagadnienia związane z zastosowaniem modelu wielofazowego Eulera do modelowania reaktora trójfazowego ze złożem stacjonarnym (TBR). Analizując równania modelu wyselekcjonowano parametry, które obliczane są w oparciu o dane dostępne w literaturze, a następnie przeprowadzono analizę czułości modelu na zmianę wartości wyselekcjonowanych parametrów. Przeanalizowano wpływ zmian zależności opisujących siły wzajemnych oddziaływań pomiędzy fazami oraz promieniowej zmiany porowatości wypełnienia na wyniki obliczeń numerycznych.