Search results for "FD"
showing 10 items of 483 documents
Evaluation of bintrafusp alfa, a bifunctional fusion protein targeting TGF-β and PD-L1, in cervical cancer: Data from phase 1 and phase 2 studies.
2021
5509 Background: The accelerated FDA approval of pembrolizumab validated the efficacy of anti–PD-(L)1 therapy for pts with recurrent/metastatic cervical cancer; however, the objective response rate (ORR) with pembrolizumab was 14.3% in pts with PD-L1 expressing tumors. HPV infection is implicated in > 95% of cervical cancers and is linked to upregulation of TGF-β signaling. Bintrafusp alfa is a first-in-class bifunctional fusion protein composed of the extracellular domain of the TGF-βRII receptor (a TGF-β “trap”) fused to a human IgG1 mAb blocking PD-L1. We report pooled safety and efficacy in pts with immune checkpoint inhibitor–naive, recurrent/metastatic cervical cancer treated with…
Experimental and fluid dynamic study of continuous supercritical water gasification of glucose
2016
Abstract The supercritical water gasification (SCWG) of glucose as a model compound for H 2 production is studied in term of process development at 25 MPa and 650 °C. Gasification has been investigated using a laboratory scale continuous plant comprising a continuous down flow reactor with a volume of 200 cm 3 , a heat recovery section and pre-heat of the biomass to simulate more closely an industrial design. Feed streams (pure water and glucose solution) are introduced at the top of the vessel and products are extracted from the bottom. The reactor is equipped with various inlet points that allow to modify the inlet position of reacting streams in order to study the effect of stream mixing…
Salbutamol Transport and Deposition in the Upper and Lower Airway with Different Devices in Cats: A Computational Fluid Dynamics Approach
2021
Simple Summary Administration of inhaled salbutamol via metered-dose inhalers can effectively treat bronchoconstriction. Different devices are used for the delivery of this drug in cats, either in the hospital or at home, for long-term treatment. Effective drug administration may depend on the drug delivery device as well as patient cooperation. By using non-invasive computational fluid dynamics techniques, the impact of these devices on the deposition and transport of salbutamol particles in the cat airways was simulated and assessed. The results confirm a variable drug distribution depending on the device used. The percentage of particles reaching the lung was reduced when using spacers a…
Lower and Upper Probability Bounds for Some Conjunctions of Two Conditional Events
2018
In this paper we consider, in the framework of coherence, four different definitions of conjunction among conditional events. In each of these definitions the conjunction is still a conditional event. We first recall the different definitions of conjunction; then, given a coherent probability assessment (x, y) on a family of two conditional events \(\{A|H,B|K\}\), for each conjunction \((A|H) \wedge (B|K)\) we determine the (best) lower and upper bounds for the extension \(z=P[(A|H) \wedge (B|K)]\). We show that, in general, these lower and upper bounds differ from the classical Frechet-Hoeffding bounds. Moreover, we recall a notion of conjunction studied in recent papers, such that the res…
A computational aeroelastic framework based on high-order structural models and high-fidelity aerodynamics
2023
A computational framework for high-fidelity static aeroelastic analysis is presented. Aeroelastic analysis traditionally employs a beam stick representation for the structure and potential, inviscid and irrotational flow assumptions for the aerodynamics. The unique contribution of this work is the introduction of a high-order structural formulation coupled with a high-fidelity method for the aerodynamics. In more details, the Carrera Unified Formulation coupled with the Finite Element Method is implemented to model geometrically complex composite, laminated structures as equivalent bi-dimensional plates. The open-source software SU2 is then used for the solution of the aerodynamic fields. T…
MODELIZACIÓN MEDIANTE CFD DE PARA EVALUAR LA VENTILACIÓN EN UN EDIFICIO ARQUEOLÓGICO, DATOS PRELIMINARES.
2016
[EN] The present study addresses the influences of wind flow structure, as an important factor responsible of material damage (erosion contributing) on “Casa di Diana” Mithraeum, a roman building (130 A.D.) sited on Ostia Antica (archaeological site, Rome – Italy), through the Computational Fluid Dynamics (CFD) simulations and direct measurements for its verification and validation (V&V). In this preliminary work, we present results relating to 3D reconstruction (geometry of the entire building) and the mesh importing on Fluent software. In general, the data check confirms, with ±10%, a good agreement (model) between the numerical solutions and direct measurements data by portable sensor. F…
Influence of drag and turbulence modelling on CFD predictions of solid liquid suspensions in stirred vessels
2014
Abstract Suspensions of solid particles into liquids within industrial stirred tanks are frequently carried out at an impeller speed lower than the minimum required for complete suspension conditions. This choice allows power savings which usually overcome the drawback of a smaller particle-liquid interfacial area. Despite this attractive economical perspective, only limited attention has been paid so far to the modelling of the partial suspension regime. In the present work two different baffled tanks stirred by Rushton turbines were simulated by employing the Eulerian-Eulerian Multi Fluid Model (MFM) along with either the Sliding Grid algorithm (transient simulations) or the Multiple Refe…
The partition sum of methane at high temperature
2008
11 pages, 4 Tables, 3 Figures Computer code on line at http://icb.u-bourgogne.fr/JSP/TIPS.jsp; International audience; The total internal partition function of methane is revisited to provide reliable values at high temperature. A multi-resolution approach is used to perform a direct summation over all the rovibrational energy levels up to the dissociation limit. A computer code is executable on line at the URL : http://icb.u-bourgogne.fr/JSP/TIPS.jsp to allow the calculation of the partition sum of methane at temperatures up to 3000 K. It also provides detailed information on the density of states in the relevant spectral ranges. The recommended values include uncertainty estimates. It is …
Resource allocation for clustered network MIMO OFDMA systems
2012
In this article, we address the resource allocation problem for the downlink of a large network multiple input multiple output orthogonal frequency division multiplexing system with 3-sector base stations. The system is statically divided into a number of disjoint clusters of sectors. A two-step resource allocation scheme is proposed involving the inter-cluster and the intra-cluster levels. As a first step or inter-cluster level, two cooperative frequency reuse approaches are designed to mitigate the inter-cluster interference. A user partition method is proposed to divide the users of each cluster into cluster-edge and cluster-center users. To balance the cell-edge and the cell-average per…
Energy-Efficient Binary Power Control with Bit Error Rate Constraint in MIMO-OFDM Wireless Communication Systems
2012
Motivated by the demand for energy efficiency improvement in mobile communication industry, we explore an idea of optimizing energy efficiency for MIMO-OFDM wireless communication systems while maintaining users' quality of service (QoS) requirement. Based on the binary power control scheme,a power allocation criterion for energy efficiency optimization is derived under the total power constraint. From a bit error rate (BER) point of view, a protection constraint is configured to guarantee the system QoS. With the aim of energy efficiency optimization under QoS guarantee in MIMO-OFDM wireless communication systems, an energy-efficient binary power control with BER constraint (EBPCB) algorith…