Search results for "FDH"
showing 3 items of 3 documents
Do dynamic effects play a significant role in enzymatic catalysis? A theoretical analysis of formate dehydrogenase.
2010
A theoretical study of the protein dynamic effects on the hydride transfer between the formate anion and nicotinamide adenine dinucleotide (NAD + ), catalyzed by formate dehydrogenase (FDH), is presented in this paper. The analysis of free downhill molecular dynamic trajectories, performed in the enzyme and compared with the reaction in aqueous solution, has allowed the study of the dynamic coupling between the reacting fragments and the protein or the solvent water molecules, as well as an estimation of the dynamic effect contribution to the catalytic effect from calculation of the transmission coefficient in the enzyme and in solution. The obtained transmission coefficients for the enzyme…
Differenziali Territoriali di Produttivita' ed Efficienza negli Anni '90: i Livelli e l'Andamento
2001
Nel presente lavoro, dopo avere effettuato una rassegna degli approcci esistenti in letteratura sulle ragioni dello sviluppo dualistico dell'economia italiana, si argomenta che per valutare il potere esplicativo di questi approcci e' importante esaminare alcune loro predizioni empiriche relativamente a livello e andamento della produttivita' totale dei fattori, nonche' degli elementi in cui queste variabili possono essere scomposte. Basandosi sui dati dell'Indagine del Mediocredito Centrale, vengono quindi calcolati per gli anni '90 misure di efficienza tecnica, di scala e allocativa, nonche' degli indici di Malmquist, per un campione piuttosto ampio (e territorialmente diversificato) di im…
PORCN mutations in focal dermal hypoplasia: coping with lethality.
2009
Contains fulltext : 81709.pdf (Publisher’s version ) (Closed access) The X-linked dominant trait focal dermal hypoplasia (FDH, Goltz syndrome) is a developmental defect with focal distribution of affected tissues due to a block of Wnt signal transmission from cells carrying a detrimental PORCN mutation on an active X-chromosome. Molecular characterization of 24 unrelated patients from different ethnic backgrounds revealed 23 different mutations of the PORCN gene in Xp11.23. Three were microdeletions eliminating PORCN and encompassing neighboring genes such as EBP, the gene associated with Conradi-Hunermann-Happle syndrome (CDPX2). 12/24 patients carried nonsense mutations resulting in loss …