Search results for "FEM"
showing 10 items of 28965 documents
Weld quality prediction in linear friction welding of AA6082-T6 through an integrated numerical tool
2016
Abstract A numerical and an experimental campaign were carried out with varying oscillation frequency and interface pressure. The local values of the main field variables at the contact interface between the specimens were predicted by a Lagrangian, implicit, thermo-mechanical FEM model and used as input of a dedicated Neural Network (NN). The NN, integrated in the FEM environment, was designed in order to calculate both a Boolean output, indicating the occurrence of welding, and a continuous output, indicating the quality of the obtained solid state weld. The analysis of the obtained results allowed three different levels of bonding quality, i.e., no weld, sound weld and excess of heat, to…
Process mechanics in Friction Stir Extrusion of magnesium alloys chips through experiments and numerical simulation
2017
Abstract Friction Stir Extrusion (FSE) is a novel process designed to directly recycle machining chips. An experimental campaign was carried out on AZ31 milling chips using variations in extrusion ratio, force and tool rotation rate. The process mechanics were studied and correlated to the material flow, which was elucidated through use of a copper marker. A 3D, Lagrangian, thermo-mechanically coupled dedicated numerical model was set up and validated through temperature measurements. The combination of experimental and numerical results permitted to reconstruct the complex 3D material flow induced by tool rotation and plunge into the extrusion billet chamber.
Surface and mechanical characterization of stationary shoulder friction stir welded lap joints: experimental and numerical approach
2020
Friction Stir Welding (FSW) is one of the most used solid-state welding processes in the aeronautical, aerospace, ground transportation and naval fields. Stationary Shoulder Friction Stir Welding (SSFSW) is a recently introduced variant of the process allowing lower heat input into the joints, with beneficial effects in terms of joint mechanical properties, microstructure and top surface finish. In the paper, lap joints produced by SSFSW and made out of AA6082-T6 aluminum alloy sheets have been analyzed with the aim to investigate the effect of the stationary shoulder on the lap joints surface, metallurgical, and mechanical properties. The lap joints produced by SSFSW have been compared to …
A numerical model for Wire integrity prediction in Friction Stir Extrusion of magnesium alloys
2017
Abstract A numerical model for the prediction of the wire quality produced by the novel direct machining chip recycling technique known as Friction Stir Extrusion (FSE) is presented. Wire microstructure and wire integrity have been predicted by embedding in the code the equations enabling the calculation of the Zener-Hollomon parameter as well as the W parameter of the Pivnik-Plata solid bonding criterion. The proposed model, developed for the AZ31 magnesium alloy using the commercial simulation package DEFORM, is 3D Lagrangian, thermo-mechanically coupled with visco-plastic material behavior. The model was first validated against experimental temperature measurements and then used to predi…
Dissimilar titanium/aluminum friction stir welding lap joints by experiments and numerical simulation
2016
Dissimilar lap joints were produced by friction stir welding (FSW) out of Ti6Al4V titanium alloy and AA2024 aluminum alloy sheets. The joints, welded with varying tool rotation and feed rate, were studied by analyzing the maximum shear strength, Vickers microhardness and optical observations. A dedicated numerical model, able to take into account the presence of the two different alloys, was used to highlight the effects of the process parameters on temperature distribution, strain distribution, and material flow. The combined analysis of experimental measurements and numerical predictions allowed explaining the effects of tool rotation and feed rate on the material flow. It was found that …
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
2017
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, …
Implantation failure of endometrial origin: what is new?
2018
To review recent findings related to possible causes of recurrent implantation failure of endometrial origin in normal uterus.Recent evidences suggest that in apparently normal endometria, RIF may associate with molecular and functional changes in the uterus such as abnormal endometrial microbiota, including the presence of chronic endometritis, poor synchronization between the blastocyst and endometrium, and/or excessive uterine peristalsis. An altered endometrial microbiota detected by molecular techniques has been recently related to poorer embryo implantation, even in apparently normal endometria. The use of the endometrial receptivity analysis test to obtain an objective signature of e…
Antitumor effect of oncolytic virus and paclitaxel encapsulated in extracellular vesicles for lung cancer treatment
2018
Standard of care for cancer is commonly a combination of surgery with radiotherapy or chemoradiotherapy. However, in some advanced cancer patients this approach might still remaininefficient and may cause many side effects, including severe complications and even death. Oncolytic viruses exhibit different anti-cancer mechanisms compared with conventional therapies, allowing the possibility for improved effect in cancer therapy. Chemotherapeutics combined with oncolytic viruses exhibit stronger cytotoxic responses and oncolysis. Here, we have investigated the systemic delivery of the oncolytic adenovirus and paclitaxel encapsulated in extracellular vesicles (EV) formulation that, in vitro, s…
Hybrid Biopolymer and Lipid Nanoparticles with Improved Transfection Efficacy for mRNA
2020
Cells 9(9), 2034 (1-19) (2020). doi:10.3390/cells9092034
Quantitative patterns of Hsps in tubular adenoma compared with normal and tumor tissues reveal the value of Hsp10 and Hsp60 in early diagnosis of lar…
2016
Large bowel carcinogenesis involves accumulation of genetic alterations leading to transformation of normal mucosa into dysplasia and, lastly, adenocarcinoma. It is pertinent to elucidate the molecular changes occurring in the pre-neoplastic lesions to facilitate early diagnosis and treatment. Heat shock proteins (Hsps), many of which are molecular chaperones, are implicated in carcinogenesis, and their variations with tumor progression encourage their study as biomarkers. There are many reports on Hsps and cancer but none to our knowledge on their systematic quantification in pre-neoplastic lesions of the large bowel. We performed immunohistochemical determinations of Hsp10, Hsp60, Hsp70, …