Search results for "FERTILITY"

O-115 Parental whole-exome sequencing allows the discovery of genetic causes of extreme IVF phenotypes such as oocyte/embryo developmental arrest and…

2021

Abstract Study question Do whole-exome sequencing (WES) data from infertile women provide valuable information for the discovery of genes/pathways involved in extreme IVF phenotypes, i.e. oocyte/embryo developmental arrest? Summary answer The development of a specific bioinformatic WES pipeline revealed known and new candidate genes/pathways for isolated oocyte/embryo developmental failure,providing the foundation to scale up research. What is known already The use of IVF has made it possible to identify extreme and isolated infertility phenotypes such as recurrent low oocytes maturity (LMR), recurrent low fertilization rate (LFR), or preimplantation developmental arrest (PDA) that would re…

Intergenomic interactions affect female reproduction: evidence from introgression and inbreeding depression in a haplodiploid mite

2004

Nuclear and cytoplasmic genomes can coevolve antagonistically or harmoniously to affect fitness. One commonly used test for nuclear-cytoplasmic coadaptation relies on the breakup of coadapted gene complexes by introgression, potentially resulting in an increased frequency of nuclear alleles in deleterious interaction with an alien cytoplasm. We investigated the phenotypic effect of such genes on female reproduction in outbred and inbred introgressed lines of the haplodiploid mite Tetranychus urticae. Introgression changed female lifetime fecundity and increased male production, in ways suggesting a control of fecundity by nuclear genes. Conversely introgression reduced the fertilization rat…

Molecular and Cellular Insights into the Development of Uterine Fibroids

2021

Uterine leiomyomas represent the most common benign gynecologic tumor. These hormone-dependent smooth-muscle formations occur with an estimated prevalence of ~70% among women of reproductive age and cause symptoms including pain, abnormal uterine bleeding, infertility, and recurrent abortion. Despite the prevalence and public health impact of uterine leiomyomas, available treatments remain limited. Among the potential causes of leiomyomas, early hormonal exposure during periods of development may result in developmental reprogramming via epigenetic changes that persist in adulthood, leading to disease onset or progression. Recent developments in unbiased high-throughput sequencing technolog…

De mujeres y diosas en la religiosidad fenicia y púnica

2012

En este trabajo realizaremos un estudio sobre el papel de la mujer en la religión fenicio-púnica y su vinculación con algunas divinidades femeninas asociadas a la fertilidad, lo que ha favorecido la aceptación de premisas que proceden de ámbitos que tradicionalmente se han caracterizado por criticar severamente lo opuesto a lo que se postula. El planteamiento de una nueva visión sobre la controvertida práctica de la prostitución sagrada asociada a estas diosas permite explorar un nuevo ámbito de estudio muy interesante en un afán de cuestionar viejas afirmaciones que no han encontrado respaldo epigráfico y arqueológico evidente. In this paper we study the role of women in the Phoenician-Pun…

Impacts of land‐use changes on soil fertility in Okomu Forest Reserve, Southern Nigeria

2021

Does age matter?: A comparison of health‐related quality of life issues of adolescents and young adults with cancer

2018

Objective:Health‐related quality of life (HRQoL) concerns of adolescents and young adults (AYAs) aged 14–25 years were compared with those of older adults (26–60 years) with cancer.Methods:AYAs and older adults receiving curative intent treatment or supportive palliative care for cancer were recruited from eight research centres across Europe. Participants used a rating scale to score the relevance and importance of a list of 77 issues covering 10 areas of HRQoL concern: symptoms; activity restrictions; social; emotional; body image; self‐appraisals; outlook on life; lifestyle; treatment‐related and life beyond treatment.Results:HRQoL issues were reviewed by 33 AYAs and 25 older adults. Sev…

Efficacy of an Internet-Based Intervention to Promote a Healthy Lifestyle on the Reproductive Parameters of Overweight and Obese Women: Study Protoco…

2020

Este artículo se encuentra disponible en la siguiente URL: https://www.mdpi.com/1660-4601/17/22/8312 En este artículo también participan: Valentina Lucia La Rosa y Rosa M. Baños. Este artículo pertenece al número especial "Developmental and emotional aspects of pregnancy, childbirth, and parenting: current and future perspectives". Background: Infertility is estimated to affect 15% of couples of reproductive age. Weight management problems (being obese or overweight) are among the problems that produce infertility, both in women seeking spontaneous pregnancy and in those undergoing assisted reproduction techniques. Over the last few decades, the prevalence of obesity has increased alarmingl…

The need for methods to measure capacity and incapacity from working life to old age

2017

Owing to a sharp increase in population ageing, a decrease in fertility and increase in life expectancy, there is an imbalance between numbers of workers entering and those leaving the workforce. The need to work longer has thus become increasingly important. To promote functional ability during extended work life and after retirement is important to ensure that people of all ages can remain active. Studies on occupational health have traditionally focused on people of working age and gerontology has studied people after retirement. These two research areas have largely remained separate, but this does not have to be the case. Both occupational health research and gerontology require a bala…

Social outcomes of long-term survivors of adolescent cancer

2010

Objectives: The study investigates psychosexual and family outcomes among German long-term survivors of adolescent cancer. Methods: Survivors of cancer during adolescence (n=820; age at onset of disease: M=15.8 years, SD=0.9, age at follow-up: M=30.4, SD=6.0 years) completed questionnaires on their family life and their psychosexual and autonomy development. Outcomes were compared to an age-matched sample (German Socio-Economic Panel, G-SOEP, n=820, age: M=30.4, SD=6.7 years) from the general population and to a control group of adults without cancer (n=1027, age: M=31.5, SD=7.0 years). Results: Compared to controls of the same sex, female survivors had achieved fewer developmental mileston…

What Are Young Women Living Conditions after Breast Cancer? Health-Related Quality of Life, Sexual and Fertility Issues, Professional Reinsertion

2020

In recent decades, the living conditions of young breast cancer (BC) survivors have garnered increasing attention. This population-based study aimed to identify the clinical, social and economic determinants of Health-Related Quality of Life (HRQoL), and to describe other living conditions of young long-term BC survivors. Women with non-metastatic BC diagnosed between 2006 and 2015, aged 45 years and younger at the time of diagnosis, were identified through the Breast and Gynecologic Cancer Registry of the C&ocirc