Search results for "FEV1"
showing 10 items of 132 documents
Intrauterine and postnatal exposure to outdoor NO2 and lung function at school age
2020
Lungs are highly vulnerable to permanent harmful effects of environmental factors during their in-utero and early life development. The detrimental effects of air pollution on lung development are well known although studies mainly focused on the postnatal exposure period. We investigated the windows of susceptibility during pregnancy and first 7 postnatal years on the association between nitrogen dioxide (NO2) and lung function at the age of 7 years in the INMA cohort in Spain. We estimated monthly average exposure to NO2 for the prenatal and postnatal period at home address of 1230 children with temporally-adjusted land use regression models. Spirometry was performed at age 7. We estimate…
Prenatal exposure to phenols and lung function, wheeze, and asthma in school-age children from 8 European birth cohorts
2019
Prenatal exposure to phenolic compounds, widely used in many consumer products, can alter lung development and increase the risk of respiratory disorders in the offspring. However, evidence is scarce and mostly focused on bisphenol-A (BPA), although there are other substitutes that could also interfere with the developing respiratory system. We aim to estimate the association between exposure to 5 phenols during pregnancy (BPA, BPAF, BPB, BPF, and BPS) and lung function, wheeze, and asthma in school-age children. We included 2685 mother-child pairs from 8 European birth cohorts. Phenols concentrations were determined in urinary maternal samples collected during pregnancy (1999-2010). Betwee…
Prenatal exposure to perfluoroalkyl substances and immune and respiratory outcomes
2018
Prenatal exposure to perfluoroalkyl substances (PFAS) may be associated with impaired immune and respiratory health during childhood but the evidence is scarce and inconsistent. We studied the association between prenatal PFAS exposure and immune and respiratory health up to age 7 years in the Spanish INMA birth cohort (n=1188). We assessed perfluorohexane sulfonate (PFHxS), perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), and perfluorononanoate (PFNA) in maternal plasma samples. Mothers reported the occurrence (yes/no) of chest infections, lower respiratory tract infections, wheezing, asthma, and eczema in the previous 12 months at 1.5 and 4 years of the child and at 7 years. A…
Prognostic significance of surrogate measures for forced vital capacity in an elderly population.
2009
Objectives To evaluate whether measures easier to obtain than the FVC can substitute it as a prognostic marker in elderly people. Design Prospective, observational study. Setting Community. Participants Outpatients (n = 1485) aged 73.4 years (SD: 6.2 range 65–98) enrolled in the Salute Respiratoria nell'Anziano (SaRA) study. Measurements We calculated the risk for mortality associated with a reduction below 80% of the predicted FVC, of the forced expiratory volume at 6 seconds (FEV6), and of a surrogate measure for forced vital capacity (SFVC), defined as the largest volume exhaled in 2 forced maneuvers regardless of its duration and of the presence of plateau. Results Among the 907 partici…
Abstract 13257: FEV1 and FVC predict Mortality in Individuals Without Manifest Lung Disease Independent of Cardiac Performance - Results From the Pop…
2015
Background: Pulmonary disease has consistently been related to increased mortality. We investigated central spirometry variables in relation to total mortality in individuals from the general population without diagnosed lung disease also accounting for cardiac function. Methods: In 15,010 individuals from the general population (mean age 55±11 years, age range 35-74 years, 50.5% men) in the Gutenberg Health Study we performed spirometry and multimodal transthoracic echocardiography. The biomarkers N-terminal pro-B-type natriuretic peptide (Nt-proBNP) and high-sensitive troponin I (TnI) were measured in the first 5000 individuals using commercially available assays. Multivariable Cox regre…
Prognostic value of FEV1/FEV6 in elderly people*
2010
Summary Background: The ratio of forced expiratory volume in 1 s and forced expiratory volume in 6 s (FEV1/FEV6) has been proposed as an alternative for FEV1/forced vital capacity (FVC) to diagnose obstructive diseases with less effort during spirometry; however, its prognostic value is unknown. We evaluated whether FEV1/FEV6 is a significant predictor of mortality in elderly subjects and compared its prognostic value with that of FEV1/FVC and FEV1. Methods: One thousand nine hundred and seventy-one subjects, aged >65 years, participated in the population-based SA.R.A. study. During the baseline exam, a multidimensional assessment included spirometry. Vital status was determined during 6 …
Early infancy BMI trajectories and lung function and asthma during childhood
2019
Previous studies assessing the association of birthweight and infant weight gain with lung function and asthma have focused on the difference between two time points or on growth patterns. Body mass index (BMI) trajectories, which integrate information on multiple aspects of growth, may allow a more accurate identification of children at higher risk of future respiratory diseases. We assessed the associations of BMI trajectories from birth to 4 years with lung function and current asthma at 7 years. We included 1399 participants from the population-based INMA birth cohort study. Five BMI trajectories were previously identified: ‘average birth size-slower BMI gain’, ‘higher birth size-accele…
Comorbidities and quality of life in obstructed adults in a primary care setting
2016
Introduction: Comorbidities are known to impair Quality of Life (QoL)in patients with chronic obstruction pulmonary disease. A poor QoL is associated with higher dyspnoea perception. How comorbidities influence QoL in these patients is limited and needs clarification. Aim: To study the role of dyspnoea perception in the relationship between comorbidities number and QoL in obstructed and not obstructed adults in a primary care setting. Methods: Seventeen general practitioners participated to the study: 566 adults, attending the Practitioner9s study for any reason, performed spirometry and fulfilled a respiratory questionnaire between January and June 2014. 259 adults (148 M, aged 40-88) acce…
666 Pulmonary Abnormalities in Children and Adolescents with Type 1 Diabetes Mellitus
2012
Background and Aims Few studies are available on pulmonary function abnormalities in children with diabetes with controversial results. Spirometric abnormalities and reduction of lung diffusing capacity for carbon monoxide (DLCO) have been reported. A cross sectional study was designed to assess whether children and adolescents with type 1 diabetes have pulmonary dysfunction. Methods Spirometry measurements were performed and DLCO was measured. The final data analysis was conducted on 57 diabetics (mean age 14.4 + 3.09 years, 31 males) and 40 healthy controls (mean age 13.6 + 2.2 years, 19 males). Results Although FVC, FEV1, FEV1/FVC of diabetics were lower than in control, significant stat…
Measuring lung function in asthmatic children: A spirometry and forced oscillation technique (FOT) comparison
2016
Background: Spirometry is the most common pulmonary function test used in asthma diagnosing. However, it requires good patient co-operation. FOT has gained increasing attention for the measurement of pulmonary function in children because it is performed at steady state breathing. Aim: To compare spirometry and FOT in order to discriminate severity of asthma according to GINA. Methods: Spirometry and FOT were performed in 176 out-patient asthmatic children (5-16 year), 100 (57%) with naive Persistent Asthma (PA) and 76 (43%) with Intermittent Asthma (IA), consecutively enrolled at the IBIM pediatric clinic. Two principal component analyses (PCA) were performed, the first (PCA1) based on FEV…