Search results for "FFR"

Pressure effects on α-synuclein amyloid fibrils: An experimental investigation on their dissociation and reversible nature

2017

α–synuclein amyloid fibrils are found in surviving neurons of Parkinson's disease affected patients, but the role they play in the disease development is still under debate. A growing number of evidences points to soluble oligomers as the major cytotoxic species, while insoluble fibrillar aggregates could even play a protection role. In this work, we investigate α–synuclein fibrils dissociation induced at high pressure by means of Small Angle X-ray Scattering and Fourier Transform Infrared Spectroscopy. Fibrils were produced from wild type α–synuclein and two familial mutants, A30P and A53T. Our results enlighten the different reversible nature of α–synuclein fibrils fragmentati…

Determinants for Tight and Selective Binding of a Medicinal Dicarbene Gold(I) Complex to a Telomeric DNA G-Quadruplex: a Joint ESI MS and XRD Investi…

2016

International audience; The dicarbene gold(I) complex [Au(9-methylcaffein-8-ylidene)(2)]BF4 is an exceptional organometallic compound of profound interest as a prospective anticancer agent. This gold(I) complex was previously reported to be highly cytotoxic toward various cancer cell lines invitro and behaves as a selective G-quadruplex stabilizer. Interactions of the gold complex with various telomeric DNA models have been analyzed by a combined ESI MS and X-ray diffraction (XRD) approach. ESI MS measurements confirmed formation of stable adducts between the intact gold(I) complex and Tel 23 DNA sequence. The crystal structure of the adduct formed between [Au(9-methylcaffein-8-ylidene)(2)]…

Structural and mechanistic insights into the interaction of the circadian transcription factor BMAL1 with the KIX domain of the CREB-binding protein

2019

JBC papers in press xx, 16604-16619 (2019). doi:10.1074/jbc.RA119.009845

Magnetite Nanoparticles Prepared By Spark Erosion

2016

Abstract In the present research, we study a possibility of using the electric spark erosion method as an alternative to the method of chemical co-precipitation for preparation of magnetic nanoparticles. Initiation of high frequency electric discharge between coarse iron particles under a layer of distilled water allows obtaining pure magnetite nanoparticles.

Experimental characterization of electronic, structural and optical properties of individual carbon nanotubes

2014

La délimitation de la citoyenneté en Côte-d'Or, d'après le droit électoral de la IIe République

1997

One of the essential elements of citizenship lies in participating in politics. Il is particulary through the right to vote that man will be fully integrated into society and take part in the decisions concerning the running of the government. Adopting universal suffrage is giving an important power to men. Thus, certain rulers have tried to channel the vote by excluding citizens liable to be detrimental to them. The law of May 31, 1850 meant to eliminate the « vile multitude », according to the expression used by Thiers. And it is in particular through the study of the concrete consequences of this law that the influence of the electoral system in the definition of citizenship can be measu…

Preparation and structural characterization of organotin(IV) complexes with ligands containing a hetero {N} atom and a hydroxy group or hydroxy and c…

2005

AbstractTwenty-two n-butyltin(IV) and t-butyltin(IV) complexes of ligands containing an –OH (–C@O) group or –OH and –COOHgroups and an aromatic {N} donor atom were prepared by metathetical reactions. On the basis of the FT-IR and Mo¨ssbauer spec-troscopic data, molecular structures were assigned to these compounds. The binding sites of the ligands were identified by means ofFT-IR spectroscopic measurements, and it was found that in most cases the organotin(IV) moiety reacts with the phenolic form ofthese ligands. In the complexes with –OH and –COOH functions, the –COOH group is coordinated to the organotin(IV) centres in amonodentate manner. The 119 Sn Mo¨ssbauer and the FT-IR studies suppor…

Modélisation du comportement des agriculteurs face au risque dans un modèle de programmation mathématique positive (PMP) à grande échelle

2017

Agricultural production is characterized for being a risky business due to weather variability, market instability, plant diseases as well as climate change and political economy uncertainty. The modelling of risk at farm level is not new, however, the inclusion of risk in Positive Mathematical Programming (PMP) models is particularly challenging. Most of the few existing PMP-risk approaches have been conducted at farm-type level and for a very limited and specific sample of farms. This implies that the modelling of risk and uncertainty at individual farm level and in a large scale system is still a challenging task. The aim of this paper is to formulate, estimate and test a robust methodol…

X-Ray characterization of 3-methyl-6,8-di(2-pyridyl)-[1,2,3]triazolo[5′,1′:6,1]pyrido[2,3-d]pyrimidine

2005

The structure of a new compound 3-methyl-6,8-di(2-pyridyl)[1,2,3]triazolo[5′,1′:6,1]pyrido[2,3- d]pyrimidine 3, formed in the reaction of 3-methyl-[1,2,3]triazolo[1,5-a]pyridine with 2-cyanopyridine, is determined by X-ray diffraction analysis. Abarca Gonzalez, Belen. Belen.Abarca@uv.es ; Ballesteros Campos, Rafael, Rafael.Ballesteros@uv.es ; Chadlaoui, Mimoun, michad@alumni.uv.es ; Ramirez de Arellano Sanchez, Maria del Carmen, Ramirezdearellano@uv.es

Optical-data storage-readout technique based on fractal encrypting masks

2009

We propose the use of fractal structured diffractive masks as keys in secure storage-readout systems. A joint transform correlator based on a photorefractive crystal in the Fourier domain is implemented to perform encryption and decryption. We discuss the advantages of encrypting information using this kind of deterministic keys in comparison to conventional random phase masks. Preliminary experimental results are presented to demonstrate the effectiveness of the proposed system.