Search results for "FIBROSIS"

showing 10 items of 901 documents

AML transformation in 56 patients with Ph- MPD in two well defined populations.

2009

The Philadelphia chromosome-negative (Ph-) chronic myeloproliferative disorders (MPD) have an inherent tendency for transformation into acute myelogenous leukaemia (AML). The long-term rate of leukaemic transformation in unselected MPD patients was studied in well-defined MPD populations in Gothenburg, Sweden and the Cote d'Or area, Burgundy, France, respectively. Over a median observation time of 15 yr, 56 subjects (7%) out of a total of 795 patients with Ph- MPD transformed to AML. The yearly incidence of AML transformation was 0.38% in polycythaemia vera (PV), 0.37% in essential thrombocythaemia (ET) and 1.09% in idiopathic myelofibrosis (IMF). The incidence of AML development was signif…

AdultMalePediatricsmedicine.medical_specialtyPolycythaemiaMyeloidIdiopathic myelofibrosisGastroenterologyLeukemia Myeloid Chronic Atypical BCR-ABL Negativehemic and lymphatic diseasesInternal medicineMedicineHumansSurvival analysisAgedAged 80 and overMyeloproliferative Disordersbusiness.industryIncidence (epidemiology)HematologyGeneral MedicineMiddle Agedmedicine.diseaseSurvival AnalysisChronic myeloproliferative disordersLeukemiamedicine.anatomical_structureFemalebusinessMale predominanceEuropean journal of haematology
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Reproducibility of the WHO histological criteria for the diagnosis of Philadelphia chromosome-negative myeloproliferative neoplasms

2014

This study, performed on behalf of the Italian Registry of Thrombocythaemias (Registro Italiano Trombocitemie), aimed to test the inter-observer reproducibility of the histological parameters proposed by the WHO classification for the diagnosis of the Philadelphia chromosome-negative myeloproliferative neoplasms. A series of 103 bone marrow biopsy samples of Philadelphia chromosome-negative myeloproliferative neoplasms consecutively collected in 2004 were classified according to the WHO criteria as follows: essential thrombocythaemia (n=34), primary myelofibrosis (n=44) and polycythaemia vera (n=25). Two independent groups of pathologists reviewed the bone marrow biopsies. The first group w…

AdultMalePolycythaemiaPathologymedicine.medical_specialtymyeloproliferative neoplasmPhiladelphia Chromosome Negativeessential thrombocythaemiaWorld Health Organizationpolycythaemia veramyeloproliferative neoplasmsPathology and Forensic MedicineYoung AdultCohen's kappaBone Marrowhemic and lymphatic diseasesBiopsyHumansMedicinePhiladelphia ChromosomeMyelofibrosisPolycythemia VeraAgedAged 80 and overObserver VariationWHO classificationmedicine.diagnostic_testbusiness.industryprimary myelofibrosiReproducibility of ResultsMiddle Agedmedicine.diseaseprimary myelofibrosisFemaleWho criteriaDifferential diagnosisessential thrombocythaemia; myeloproliferative neoplasms; primary myelofibrosis; polycythaemia vera; WHO classificationbusinessWho classificationThrombocythemia EssentialModern Pathology
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Oxygen Radical Production by Alveolar Inflammatory Cells in Idiopathic Pulmonary Fibrosis

1990

Idiopathic pulmonary fibrosis (IPF) is a chronic inflammatory interstitial lung disease characterized by the accumulation of alveolar macrophages (AMs) and neutrophils in the lower respiratory tract, parenchymal cell injury, and fibrosis of the alveolar structure. Reactive oxygen intermediates (ROI) are claimed to be a major cause of tissue damage in IPF; however, the source of ROI has not been unequivocally identified. AMs, as well as neutrophils, are capable of releasing these agents. The contributions of these possible sources are not known. To address this question, we evaluated the spontaneous and stimulated (PMA or zymosan) ROI release of total bronchoalveolar cells and isolated AMs i…

AdultMalePulmonary and Respiratory MedicinePathologymedicine.medical_specialtyFree RadicalsNeutrophilsPrednisolonePulmonary FibrosisCell CountInflammationchemistry.chemical_compoundIdiopathic pulmonary fibrosisFibrosismedicineHumansLungmedicine.diagnostic_testSuperoxide Dismutasebusiness.industryMacrophagesZymosanZymosanInterstitial lung diseaseMiddle Agedrespiratory systemmedicine.diseaserespiratory tract diseasesOxygenPulmonary Alveolimedicine.anatomical_structureBronchoalveolar lavagechemistryLuminescent MeasurementsImmunologyTetradecanoylphorbol AcetateFemalemedicine.symptombusinessBronchoalveolar Lavage FluidRespiratory tractAmerican Review of Respiratory Disease
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Impact of SARS-CoV-2 infection in patients with cystic fibrosis in Spain: Incidence and results of the national CF-COVID19-Spain survey

2020

CF-COVID19-Spain Registry Group.

AdultMalePulmonary and Respiratory MedicinePediatricsmedicine.medical_specialtyPneumonia ViralPopulationDiseaseRisk AssessmentCystic fibrosisArticleCystic fibrosisBetacoronavirus03 medical and health sciencesCOVID-19 Testing0302 clinical medicinemedicineHumansRegistries030212 general & internal medicineMortalityeducationPandemicsRetrospective Studieseducation.field_of_studyClinical Laboratory Techniquesbusiness.industrySARS-CoV-2IncidenceIncidence (epidemiology)Mortality rateCOVID-19Retrospective cohort studymedicine.diseaseCoronavirus030228 respiratory systemSpainFemaleObservational studyCoronavirus InfectionsRisk assessmentbusiness
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Risk factors for cystic fibrosis arthropathy: Data from the German cystic fibrosis registry

2021

Epidemiology and potential risk factors for cystic fibrosis arthropathy (CFA) were studied in a relevant cystic fibrosis (CF) patient cohort.Cohort study of patients included in the German CF registry in 2016-2017. Descriptive analysis, exploratory tests and multivariable logistic regression were used to assess prevalence of CFA and associated potential risk factors for adult patients with/without chronic Pseudomonas aeruginosa infection.6069 CF patients aged from 0 to 78 years were analysed. CFA was observed in 4.9% of the patients. Prevalence was significantly higher in adult patients (8.4%) compared to patients18 years (0.7%; p0.0001). Logistic regression analyses in adult patients (n=33…

AdultMalePulmonary and Respiratory Medicinemedicine.medical_specialtyAdolescentCystic FibrosisCystic fibrosis-related diabetesmedicine.disease_causeLogistic regressionCystic fibrosisDiabetes ComplicationsSex FactorsRisk FactorsGermanyInternal medicineArthropathyEpidemiologyPrevalencemedicineHumansPseudomonas InfectionsRegistriesSinusitisChildAgedPseudomonas aeruginosabusiness.industryAge FactorsInfant NewbornInfantMiddle Agedmedicine.diseaseChild PreschoolPediatrics Perinatology and Child HealthCohortExocrine Pancreatic InsufficiencyFemaleJoint DiseasesbusinessCohort studyJournal of Cystic Fibrosis
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Glutathione and glutathione peroxidase in sputum samples of adult patients with cystic fibrosis

2004

AbstractBackground: Reduced glutathione (GSH) is a major antioxidant in the lung. In cystic fibrosis (CF) patients, extracellular GSH levels of lower airways, obtained by bronchoalveolar lavage (BAL), were reported to be lower than non-CF individuals. Methods: Upper airway secretions of stable adult CF patients (29 spontaneous and 13 induced sputum) and non-CF individuals (14 healthy and 12 asthmatics; all induced sputum) were analyzed for total glutathione (i.e. the sum of reduced, GSH, and oxidized, GSSG, forms), GSH and GSSG levels by enzymatic kinetic assay. Results: In CF, both spontaneous and induced sputum samples were comparable in total glutathione levels which were surprisingly hi…

AdultMalePulmonary and Respiratory Medicinemedicine.medical_specialtyAntioxidantCystic Fibrosismedicine.medical_treatmentCystic fibrosisAntioxidantschemistry.chemical_compoundInternal medicineExtracellularmedicineUpper airway secretionsHumansPediatrics Perinatology and Child HealthLung inflammatory diseaseschemistry.chemical_classificationGlutathione PeroxidaseLungmedicine.diagnostic_testbusiness.industryGlutathione peroxidaseSputumAntioxidant levelsGlutathionemedicine.diseaseGlutathionerespiratory tract diseasesBronchoalveolar lavagemedicine.anatomical_structureEndocrinologyCross-Sectional StudieschemistryPediatrics Perinatology and Child HealthImmunologySputumFemalemedicine.symptombusinessOxidation-ReductionJournal of Cystic Fibrosis
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Predicting hypoxia in cystic fibrosis patients during exposure to high altitudes

2006

Abstract Background For patients with cystic fibrosis (CF)-related partial respiratory insufficiency and reduced arterial oxygen tension at ground level, the mild hypobaric environment on commercial jet aircraft poses the risk of severe hypoxemia. Thus, physicians should be able to estimate the extent of in-flight hypoxia. Objectives To derive tools for estimating the expected drop in arterial oxygen partial pressure (paO 2 ) and oxygen saturation (saO 2 ) in young adult CF patients with mild to moderate airway obstruction during exposure to the hypobaric conditions aboard commercial aircraft and to test the predictive power of a hypobaric chamber simulation. Methods Blood gases of 12 CF pa…

AdultMalePulmonary and Respiratory Medicinemedicine.medical_specialtyAtmosphere Exposure ChambersAircraftCystic FibrosisOxygen saturationHypobaric hypoxemiaAltitude SicknesspCO2HypoxemiaFEV1/FVC ratioAltitudeInternal medicinemedicineHumansCystic fibrosis (CF)Pediatrics Perinatology and Child HealthRespiratory systemAltitude sicknessCommercial flightsTravelbusiness.industryAirway obstructionrespiratory systemmedicine.diseaseSurgeryrespiratory tract diseasesAtmospheric PressureHypobaric chamberPediatrics Perinatology and Child HealthCardiologyOxygen partial pressureFemalemedicine.symptomBlood Gas AnalysisbusinessForecastingcirculatory and respiratory physiologyJournal of Cystic Fibrosis
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Bilobectomy for massive hemoptysis after bilateral lung transplantation

2001

AbstractJ Thorac Cardiovasc Surg 2001;121:1194-5

AdultMaleReoperationPulmonary and Respiratory Medicinemedicine.medical_specialtyHemoptysisCystic Fibrosismedicine.medical_treatmentRisk AssessmentSeverity of Illness IndexBilobectomyPneumonectomymedicineLung transplantationHumansPneumonectomyVascular FistulaLungbusiness.industryRespiratory diseaserespiratory systemmedicine.diseaseBronchial FistulaSurgeryTransplantationmedicine.anatomical_structureTreatment OutcomeSurgeryBronchial FistulaComplicationbusinessCardiology and Cardiovascular MedicineFollow-Up StudiesLung TransplantationThe Journal of Thoracic and Cardiovascular Surgery
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Use of ADCON®-L to Prevent Peridural Fibrosis Following Re-Operation for Recurrent Lumbar Radiculopathy: Clinical Results

2002

OBJECTIVE To present the results of a small retrospective study in patients after they have undergone lumbar scar resection and ADCON-L application to prevent recurrent formation of peridural fibrosis. PATIENTS AND METHODS Between May 1996 and December 1999 nineteen patients underwent surgery for peridural fibrosis. Sixteen patients were eligible for statistical analysis. The mean age was 46.2 years (range 29 to 69 years) and the mean follow-up period was 9.7 months with a range of 3 to 38 months. In 10 patients scar formation was the main factor for nerve root compression. Three out of these patients showed concomitant recurrent disc herniation. Six patients presented with peridural fibros…

AdultMaleReoperationmedicine.medical_specialtyNerve rootDecompressionCicatrixLumbarRecurrenceHumansMedicineOrganic ChemicalsRadiculopathyAgedRetrospective StudiesAdcon-Lbusiness.industryLumbosacral RegionRetrospective cohort studyGeneral MedicineMiddle AgedFibrosisSurgeryIntervertebral diskTreatment OutcomeConcomitantSurgeryDura MaterNeurology (clinical)ComplicationbusinessGelsmin - Minimally Invasive Neurosurgery
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Correlations Between Clinical and Histological Aspects in Nasal Polyposis

2008

Introduction The histological study of nasal polyps does not reveal any specific lesions but eosinophilic infiltration nasal mucosae seems to be characteristic of nasal polyposis. The aim of this work is to study possible links between certain histological and clinical aspects in nasal polyposis. Furthermore, we attempt to compare the quantification of tissue eosinophilia according to the number of eosinophils per field with the percentage figure obtained with respect to the total of inflammatory cells. Material and method We have studied 40 patients with idiopathic bilateral nasal polyposis, assessing the correlations between various clinical aspects such as their endoscopic and radiologic…

AdultMaleRespiratory MucosaPathologymedicine.medical_specialtyMucous membrane of noseNasal PolypsFibrosisMetaplasiaEosinophiliaotorhinolaryngologic diseasesmedicineHumansEosinophiliaNasal polypsAgedbusiness.industryGeneral MedicineMiddle Agedrespiratory systemEosinophilmedicine.diseasemedicine.anatomical_structureFemalemedicine.symptombusinessInfiltration (medical)Acta Otorrinolaringologica (English Edition)
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