Search results for "FISIOLOGIA"
showing 10 items of 672 documents
ALS-RELATED FUS PROTEIN IS MISLOCALIZED TO CYTOPLASM AND RECRUITED INTO STRESS GRANULES IN FIBROBLASTS OF ASYMPTOMATIC FUS P525L MUTATION CARRIERS
Symptoms onset in Amyotrophic Lateral Sclerosis (ALS) occur when over 70% of motor neurons is already lost, suggesting a relatively long pre-symptomatic phase. The description of several genes linked to ALS (e.g., SOD1, FUS, TARDP, C9orf72) has now allowed identification of pre-symptomatic carriers. These pre-symptomatic (or even preclinical) carriers can be followed up with the aim to identify the very early clinical disease-related changes or a valuable biomarker. These efforts seem at present the best approach for the implementation of an early symptomatic therapy or for the disease prevention. In this work, we studied the expression of FUS protein in cultured skin fibroblasts from pre-s…
Valutazione della resistenza allo stress salino di Puccinellia distans (Jacq.) Parl. trattata con applicazioni fogliari dell'osmoregolatore glicinbet…
2009
La termoregolazione corporea
2009
Effects of mild aerobic exercise training on the diaphragm in mdx mice
2016
Mild endurance exercise training positively affects limb skeletal muscle in the mdx mice model of Duchenne Muscular Dystrophy (DMD). However, few and controversial data are available on the effects of mild exercise training on the diaphragm of mdx mice. The diaphragm was examined in mdx and wild type mice either under sedentary conditions (mdx-SD, WT-SD) or during mild exercise training (mdx-EX, WT-EX). At baseline and after 30 and 45 days of training (5 d/wk for 6 weeks), diaphragm muscle morphology and Cx39 protein were assessed. In addition, tissue levels of the chaperonin Hsp60 were measured at the same time points in gastrocnemius, quadriceps and diaphragm in each experimental group. A…
Effects of endurance training on small airways of mice
2006
Beneficial effects of low intensity endurance training in adult mdx mise
2009
No effects of low-intensity endurance exercise on muscle necrosis in the diaphragm of mdx mice
2014
Duchenne muscular dystrophy (DMD) is characterized by progressive skeletal muscle weakness. We have previously shown that low-intensity endurance training prevented muscle damage (Frinchi et al, Int J Sports Med 2014). Since the effects of low-intensity endurance training on the the diaphragm in the mdx mouse model are unknown, in the same animals we investigated Cx39 protein levels (Western blotting) in homogenates of the diaphragm before and after training. Mdx and wild-type (WT) mice were randomly assigned to sedentary (mdx-S, n=17; WT-S, n=19) or trained (mdx-EX, n=14; WT-EX, n=16) groups. Low-intensity endurance training (running on a wheel) was done 5 days/week for 6 weeks at progress…
Characterization of maternal behaviours in mice. Pheromonal control and nonapeptidergic substrate
2016
1. INTRODUCCIÓN El comportamiento parental se da en una gran amplia variedad de especies de vertebrados e invertebrados, pero es especialmente importante en mamíferos y aves (Numan and Insel, 2003). Numan e Insel definieron este comportamiento como “cualquier comportamiento de un miembro de una especie hacia un conespecífico reproductivamente inmaduro que incrementa las probabilidades de que el receptor sobreviva hasta la madurez” (Numan e Insel, 2003). Aunque, especialmente en mamíferos, la mayor parte del cuidado lo llevan a cabo las hembras, en algunas especies los machos muestran comportamiento parental, lo que se conoce como comportamiento paternal. Por otro lado, en algunas aves y mam…