Search results for "FLUX"
showing 10 items of 1392 documents
The influence of thin hard coatings on frictional behaviour in the orthogonal cutting process
2000
New knowledge about the tribological response deriving from the interaction of the substrate/coating-chip system, with special attention to the orthogonal cutting process when chatter-free end turning using natural contact tools, is developed. In order to evaluate the frictional behaviour of this process under modified contact conditions, experimental investigations including the contact temperature, the contact loads, friction and the frictional heat flux per unit area were carried out. In contrast to the most obvious approach, the coefficient of sliding friction versus the cutting speed, the contact temperature, the normal pressure and the interface control factor is considered. A number …
Clathrin-mediated constitutive endocytosis of PIN auxin efflux carriers in Arabidopsis.
2007
SummaryEndocytosis is an essential process by which eukaryotic cells internalize exogenous material or regulate signaling at the cell surface [1]. Different endocytic pathways are well established in yeast and animals; prominent among them is clathrin-dependent endocytosis [2, 3]. In plants, endocytosis is poorly defined, and no molecular mechanism for cargo internalization has been demonstrated so far [4, 5], although the internalization of receptor-ligand complexes at the plant plasma membrane has recently been shown [6]. Here we demonstrate by means of a green-to-red photoconvertible fluorescent reporter, EosFP [7], the constitutive endocytosis of PIN auxin efflux carriers [8] and their …
Azole-resistant Aspergillus fumigatus: A global phenomenon originating in the environment?
2019
Abstract Aspergillus fumigatus is the predominant etiological agent of invasive aspergillosis (IA), a difficult-to-manage fungal disease associated with a high case fatality rate. Azole antifungals, particularly voriconazole, have significantly improved the survival rate of patients with IA. However, the clinical advances made possible through the use of medical azoles could be threatened by the emergence of azole-resistant strains which has been reported in an ever-increasing number of countries over the last 10 years. The major resistance mechanism, that combines point mutation(s) in the coding sequence of cyp51A gene and an insertion of a tandem repeat in the promoter region of this gene…
Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3.
2009
The Hsc/Hsp70 co-chaperones of the BAG (Bcl-2-associated athanogene) protein family are modulators of protein quality control. We examined the specific roles of BAG1 and BAG3 in protein degradation during the aging process. We show that BAG1 and BAG3 regulate proteasomal and macroautophagic pathways, respectively, for the degradation of polyubiquitinated proteins. Moreover, using models of cellular aging, we find that a switch from BAG1 to BAG3 determines that aged cells use more intensively the macroautophagic system for turnover of polyubiquitinated proteins. This increased macroautophagic flux is regulated by BAG3 in concert with the ubiquitin-binding protein p62/SQSTM1. The BAG3/BAG1 ra…
Indications for Anti-Reflux Surgery in Barrett's Esophagus
2014
Volcanic CO2 tracks the incubation period of basaltic paroxysms
2021
Description
Unusually large magmatic CO2gas emissions prior to a basaltic paroxysm
2010
[1] The low-intensity activity of basaltic volcanoes is occasionally interrupted by short-lived but energetic explosions which, whilst frequently observed, are amongst the most enigmatic volcanic events in Nature. The combination of poorly understood and deep, challenging to measure, source processes make such events currently impossible to forecast. Here we report increases in quiescent degassing CO2 emissions (>10,000 t/day) prior to a powerful explosive event on Stromboli volcano on 15 March 2007. We interpret such large CO2 flux as being sourced by passive gas leakage from a deeply (>4 km) stored magma, whose depressurization, possibly caused by the onset of an effusive eruption on 28 F…
First observational evidence for the CO<sub>2</sub>-driven origin of Stromboli's major explosions
2011
Abstract. We report on the first detection of CO2 flux precursors of the till now unforecastable "major" explosions that intermittently occur at Stromboli volcano (Italy). An automated survey of the crater plume emissions in the period 2006–2010, during which 12 such explosions happened, demonstrated that these events are systematically preceded by a brief phase of increasing CO2/SO2 weight ratio (up to >40) and CO2 flux (>1300 t d−1) with respect to the time-averaged values of 3.7 and ~500 t d−1 typical for standard Stromboli's activity. These signals are best explained by the accumulation of CO2-rich gas at a discontinuity of the plumbing system (decreasing CO2 emission at the surfa…
Activity from the Be/X-ray binary system V0332+53 during its intermediate-luminosity outburst in 2008
2015
Aims: We present a study of the Be/X-ray binary system V 0332+53 with the main goal of characterizing its behavior mainly during the intermediate-luminosity X-ray event on 2008. In addition, we aim to contribute to the understanding of the global behavior of the donor companion by including optical data from our dedicated campaign starting on 2006. Methods: V 0332+53 was observed by RXTE and Swift during the decay of the intermediate-luminosity X-ray outburst of 2008, as well as with Suzaku before the rising of the third normal outburst of the 2010 series. In addition, we present recent data from the Spanish ground-based astronomical observatories of El Teide (Tenerife), Roque de los Muchac…