Search results for "FN"
showing 10 items of 862 documents
Novel form of X-linked nonsyndromic hearing loss with cochlear malformation caused by a mutation in the type IV collagen gene COL4A6
2013
Hereditary hearing loss is the most common human sensorineural disorder. Genetic causes are highly heterogeneous, with mutations detected in >40 genes associated with nonsyndromic hearing loss, to date. Whereas autosomal recessive and autosomal dominant inheritance is prevalent, X-linked forms of nonsyndromic hearing impairment are extremely rare. Here, we present a Hungarian three-generation family with X-linked nonsyndromic congenital hearing loss and the underlying genetic defect. Next-generation sequencing and subsequent segregation analysis detected a missense mutation (c.1771G>A, p.Gly591Ser) in the type IV collagen gene COL4A6 in all affected family members. Bioinformatic analysis an…
Effects of self-myofascial release: A systematic review.
2015
Summary Background Self-myofascial release (SMFR) is a type of myofascial release performed by the individual themselves rather than by a clinician, typically using a tool. Objectives To review the literature regarding studies exploring acute and chronic clinical effects of SMFR. Methods PubMed and Google Scholar databases were searched during February 2015 for studies containing words related to the topic of SMFR. Results Acutely, SMFR seems to increase flexibility and reduce muscle soreness but does not impede athletic performance. It may lead to improved arterial function, improved vascular endothelial function, and increased parasympathetic nervous system activity acutely, which could b…
Optimal design of flax fiber reinforced polymer composite as a lightweight component for automobiles from a life cycle assessment perspective
2019
The present study combines the generalized rule-of-mixture (ROM) model and the Ashby material selection method for the life cycle assessment (LCA) of flax fiber reinforced polymers (FRPs) and glass FRPs (GFRPs). The ROM model allows life cycle environmental impact predictions according to specific parameters of flax FRPs such as fiber format, volume fraction, manufacturing technique, and load-bearing capacity. The comparisons applied in this study are constructed on two common composite structures: mat panels and injection molded struts with equal stiffness and strength as the design criteria. On the one hand, the parametric LCA predicts that the equal strength design criterion for flax FRP…
A symmetric tangent stiffness approach to cohesive mechanical interfaces in large displacements
2022
The present article proposes a formulation for a cohesive interface element in large displacement conditions. Theoretical and computational aspects, useful for an effective and efficient finite element implementation, are examined in details. A six-node (or higher) isoparametric interface element for two dimensional cohesive fracture propagation problems is developed. The element operators are consistently derived by a variational approach enforced in the current configuration, where a current frame is defined with axes tangential and normal to the middle line of the interface opening displacement gap. Under the constitutive assumption of small value of the modulus of the vector product bet…
Deep Learning-Based Methods for Prostate Segmentation in Magnetic Resonance Imaging
2021
Magnetic Resonance Imaging-based prostate segmentation is an essential task for adaptive radiotherapy and for radiomics studies whose purpose is to identify associations between imaging features and patient outcomes. Because manual delineation is a time-consuming task, we present three deep-learning (DL) approaches, namely UNet, efficient neural network (ENet), and efficient residual factorized convNet (ERFNet), whose aim is to tackle the fully-automated, real-time, and 3D delineation process of the prostate gland on T2-weighted MRI. While UNet is used in many biomedical image delineation applications, ENet and ERFNet are mainly applied in self-driving cars to compensate for limited hardwar…
Concurrent Changes of Brain Functional Connectivity and Motor Variability When Adapting to Task Constraints
2018
In behavioral neuroscience, the adaptability of humans facing different constraints has been addressed on one side at the brain level, where a variety of functional networks dynamically support the same performance, and on the other side at the behavioral level, where fractal properties in sensorimotor variables have been considered as a hallmark of adaptability. To bridge the gap between the two levels of observation, we have jointly investigated the changes of network connectivity in the sensorimotor cortex assessed by modularity analysis and the properties of motor variability assessed by multifractal analysis during a prolonged tapping task. Four groups of participants had to produce th…
Some comments on the experimental behavior of FRC beams in flexure
2008
In the present paper the experimental results, recently obtained by the authors, regarding the monotonic and the cyclic flexural response of normal and high-strength concrete beams reinforced with steel bars and discontinuous fibers, are shown. From the experimental results, all referred to low values of shear-to-depth ratios, it emerges clearly that the shear failure is brittle especially under cyclic actions highlighting the role of the fibers in the flexural behavior of the beams. The cyclic action produces a significant decay in the stiffness and in the strength capacity of the beams, and the addition of fibers reduces these negative effects. Form theoretical point of view good agreemen…
Crack bifurcations in a strained lattice
1996
Dynamic crack propagation in a strained, granular, and brittle material is investigated by modeling the material as a lattice network of elastic beams. By tuning the strain and the ratio of axial to bending stiffness of the beams, a crack propagates either straight, or it branches, or it bifurcates. The crack tip velocity is calculated approximately for cracks that propagate straight. In a bifurcated crack the number of broken beams follows a scaling law. The shape of the branches is found to be the same as in recent experiments.
Dynamic analysis for axially moving viscoelastic panels
2012
In this study, stability and dynamic behaviour of axially moving viscoelastic panels are investigated with the help of the classical modal analysis. We use the flat panel theory combined with the Kelvin–Voigt viscoelastic constitutive model, and we include the material derivative in the viscoelastic relations. Complex eigenvalues for the moving viscoelastic panel are studied with respect to the panel velocity, and the corresponding eigenfunctions are found using central finite differences. The governing equation for the transverse displacement of the panel is of fifth order in space, and thus five boundary conditions are set for the problem. The fifth condition is derived and set at the in-…
A symmetric nonlocal damage theory
2003
The paper presents a thermodynamically consistent formulation for nonlocal damage models. Nonlocal models have been recognized as a theoretically clean and computationally efficient approach to overcome the shortcomings arising in continuum media with softening. The main features of the presented formulation are: (i) relations derived by the free energy potential fully complying with nonlocal thermodynamic principles; (ii) nonlocal integral operator which is self-adjoint at every point of the solid, including zones near to the solid's boundary; (iii) capacity of regularizing the softening ill-posed continuum problem, restoring a meaningful nonlocal boundary value problem. In the present app…