Search results for "FN"
showing 10 items of 862 documents
Improvement of ALT decay kinetics by all-oral HCV treatment: Role of NS5A inhibitors and differences with IFN-based regimens
2017
Background Intracellular HCV-RNA reduction is a proposed mechanism of action of direct-acting antivirals (DAAs), alternative to hepatocytes elimination by pegylated-interferon plus ribavirin (PR). We modeled ALT and HCV-RNA kinetics in cirrhotic patients treated with currently-used all-DAA combinations to evaluate their mode of action and cytotoxicity compared with telaprevir (TVR)+PR. Study design Mathematical modeling of ALT and HCV-RNA kinetics was performed in 111 HCV-1 cirrhotic patients, 81 treated with all-DAA regimens and 30 with TVR+PR. Kinetic-models and Cox-analysis were used to assess determinants of ALT-decay and normalization. Results HCV-RNA kinetics was biphasic, reflecting …
Genome-wide association analysis on normal hearing function identifies PCDH20 and SLC28A3 as candidates for hearing function and loss.
2015
Hearing loss and individual differences in normal hearing both have a substantial genetic basis. Although many new genes contributing to deafness have been identified, very little is known about genes/variants modulating the normal range of hearing ability. To fill this gap, we performed a two-stage meta-analysis on hearing thresholds (tested at 0.25, 0.5, 1, 2, 4, 8 kHz) and on pure-tone averages (low-, medium-and high-frequency thresholds grouped) in several isolated populations from Italy and Central Asia (total N = 2636). Here, we detected two genome-wide significant loci close to PCDH20 and SLC28A3 (top hits: rs78043697, P = 4.71E-10 and rs7032430, P = 2.39E-09, respectively). For both…
Epidemiological study of nonsyndromic hearing loss in Sicilian newborns
2007
Deafness is caused by a variety of facts, genetic and environmental. Regarding the acquired causes, deafness can be the consequence of prenatal infections, acoustic or cerebral trauma, and the use of ototoxic drugs. Deafness can be the only manifestation (nonsyndromic forms) or it may occur together with other phenotypic findings (syndromic forms). The majority of nonsyndromicdeafness has a genetic basis [Van Camp et al., 1997]. In recent years, deafness and hearing loss have assumed a clinical importance in the study of congenital disorders [Morton et al., 1991]. The clinical interest for hearing loss is supported by the social impact that this disorder has; if not treated, delays in the d…
Zirconium, Hafnium and Rare Earths behaviour during the transport in volcanic fluids. Geochemical effects throughout the sublimation and after intera…
This research indicates the fate of Zr, Hf and Rare Earths during their sublimation from the high-temperature gas phase (100° - 420 °C), in volcanic systems associated with different geodynamic regimes, and processes associated with volcanic sublimation representing the last natural “inorganic” interface where a detailed investigation into the behaviour of Rare Earths had never been conducted. The research was carried out in active volcanic systems at Vulcano (Aeolian Islands, Italy), Santorini (Cyclades Islands, Greece), Phlegrean Fields (Italy), Tenerife (Canary Islands, Spain) and Fogo Island (Cape Verde) where both fumaroles and thermal waters from submarine springs and inland wells wer…
Prospective relationship of change in ideal cardiovascular health status and arterial stiffness: the Cardiovascular Risk in Young Finns Study.
2014
Background In 2010, the American Heart Association defined ideal cardiovascular health as the simultaneous presence of 4 favorable health behaviors (nonsmoking, ideal body mass index, physical activity at goal, and dietary pattern that promotes cardiovascular health) and 3 favorable health factors (ideal levels of total cholesterol, blood pressure, and fasting glucose). The association between a change in ideal cardiovascular health status and pulse wave velocity, a surrogate marker of cardiovascular disease, has not been reported. Methods and Results The study cohort consisted of 1143 white adults from the Cardiovascular Risk in Young Finns Study who were followed for 21 years since basel…
Advanced glycation end products measured by skin autofluorescence are associated with melancholic depressive symptoms - Findings from Helsinki Birth …
2021
Background: Millions of people live with depression and its burden of disease. Depression has an increased comorbidity and mortality that has remained unexplained. Studies have reported connections between advanced glycation end products (AGEs) and various disease processes, including mental health. The present study evaluated associations between AGEs, depressive symptoms, and types of depressive symptoms. Methods: From the Helsinki Birth Cohort Study, 815 participants with a mean age of 76 years were recruited for this cross-sectional study. Characteristics regarding self-reported lifestyle and medical history, as well as blood tests were obtained along with responses regarding depressive…
Effect of steel collars on the seismic behaviour of axially-cracked historical stone columns
2014
Granite and heavy stone circular columns could often be found in the cultural heritage among ancient churches and historical buildings in all the Mediterranean area. Their good strength properties allow them to carry big load values, while their bright colours and aesthetical characteristics were used by a lot of architects in the past to achieve structural solutions with great visual impact.Though such materials have great compressive strength values, environmental effects, especially long term effects, can damage the structural members, by cracking them. In this way the slenderness of the column increases, and the presence of an imposed ground motion can be very dangerous, since the colum…
Brief an Garlieb H. Merkel
1798
Ms. 930a, Nr. 10, Bl. 26r-28v Schmidt-Phiseldeck, Konrad von. Brief an Garlieb H. Merkel, Kopenhagen, am 6. März 1798 Autora rokraksts / Autograph, vācu un latīņu val. / Deutsch und Latein [6] lpp. / S. Attēlu numuri / Bildnummern: 930a-010-1 – 930a-010-6 Der Verfasser äußert zum Beginn seines Briefes erneut sein Bedauern über die räumliche Trennung und wünscht sich, nach Italien zu reisen. Weimar, wo Merkel zum gegebenen Zeitpunkt wahrscheinlich weilte, glorifiziert Schmidt-Phiseldeck mit der Bezeichnung als „Weimar-Athen“. Gleichzeitig drückt der Verfasser seine Enttäuschung über die Politik Frankreichs bezüglich der Schweiz aus, erkennt aber in der Neutralität seiner neuen Heimat Dänemar…