Search results for "FN"

showing 10 items of 862 documents

Local Application of Leptin Antagonist Attenuates Angiotensin II–Induced Ascending Aortic Aneurysm and Cardiac Remodeling

2016

Background Ascending thoracic aortic aneurysm ( ATAA ) is driven by angiotensin II (Ang II ) and contributes to the development of left ventricular ( LV ) remodeling through aortoventricular coupling. We previously showed that locally available leptin augments Ang II ‐induced abdominal aortic aneurysms in apolipoprotein E–deficient mice. We hypothesized that locally synthesized leptin mediates Ang II ‐induced ATAA . Methods and Results Following demonstration of leptin synthesis in samples of human ATAA associated with different etiologies, we modeled in situ leptin expression in apolipoprotein E–deficient mice by applying exogenous leptin on the surface of the ascending aorta. This treatm…

LeptinMale0301 basic medicineAortic valveTranslational StudiesMice Knockout ApoEaortic valve stenosisangiotensin II030204 cardiovascular system & hematologyLeft ventricular hypertrophyVascular MedicineMiceAortic aneurysm0302 clinical medicineVasoconstrictor AgentsMedicineCells CulturedOriginal ResearchAged 80 and overVentricular RemodelingLeptindigestive oral and skin physiologyMiddle Agedleft ventricular hypertrophymedicine.anatomical_structureAortic ValveAortic valve stenosiscardiovascular systemCardiologyFemaleHypertrophy Left VentricularCardiology and Cardiovascular Medicineaortic aneurysmhormones hormone substitutes and hormone antagonistsAdultmedicine.medical_specialtyvascular remodelingThoracic aortic aneurysmYoung Adult03 medical and health sciencesVascular Stiffnessmedicine.arteryInternal medicineAscending aortaAnimalsHumansAgedCell ProliferationAortic Aneurysm Thoracicbusiness.industryleptin antagonistmedicine.diseaseAneurysmAngiotensin II030104 developmental biologyEndocrinologyAnimal Models of Human DiseaseValvular Heart DiseasebusinessJournal of the American Heart Association
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IgG Fc sialylation is regulated during the germinal center reaction following immunization with different adjuvants

2020

Background: Effector functions of IgG Abs are regulated by their Fc N-glycosylation pattern. IgG Fc glycans that lack galactose and terminal sialic acid residues correlate with the severity of inflammatory (auto)immune disorders and have also been linked to protection against viral infection and discussed in the context of vaccine-induced protection. In contrast, sialylated IgG Abs have shown immunosuppressive effects.Objective: We sought to investigate IgG glycosylation programming during the germinal center (GC) reaction following immunization of mice with a foreign protein antigen and different adjuvants.Methods: Mice were analyzed for GC T-cell, B-cell, and plasma cell responses, as wel…

Lipopolysaccharides0301 basic medicineGlycosylationT-LymphocytesFreund's AdjuvantPolysorbatesPlasma cellchemistry.chemical_compound0302 clinical medicineImmunology and AllergyMice KnockoutB-Lymphocytesbiologyddc:3. Good healthT follicular cellsIL-17medicine.anatomical_structureAlum CompoundsCytokinesFemaleAntibodySqualeneGlycosylationOvalbuminIgG glycosylationImmunologyAntibodiesIFN-gamma03 medical and health sciencesImmune systemAdjuvants ImmunologicAntigenmedicineAnimalsMineral OilAntigensIL-6IL-27RCord factorGerminal centerMycobacterium tuberculosisDendritic cellvaccinationMice Inbred C57BLcarbohydrates (lipids)030104 developmental biologychemistryadjuvantsgerminal centerImmunoglobulin GImmunologybiology.protein030215 immunologyJournal of Allergy and Clinical Immunology
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New functional ligands for ficolin-3 among lipopolysaccharides of Hafnia alvei.

2011

Ficolin-1 (M), ficolin-2 (L), ficolin-3 (H) and mannan-binding lectin (MBL) activate the complement system and have opsonic activity. The specificity of ficolin-3 is poorly characterized and currently limited to a few ligands only. We present new specific targets for human ficolin-3, identified among lipopolysaccharides (LPSs, endotoxin) of Hafnia alvei. The interaction was restricted to LPSs of four strains: 23, Polish Collection of Microorganisms (PCM) 1200, PCM 1203 and PCM 1205 and limited to their O-specific polysaccharides (O-specific PSs) composed of different numbers of oligosaccharide (OS) repeating units (RUs). Moreover, these LPS/ficolin-3 complexes activated the lectin pathway o…

LipopolysaccharidesDisaccharideLigandsBiochemistrychemistry.chemical_compoundLectinsAnimalsHumansBovine serum albuminOpsoninchemistry.chemical_classificationbiologyLectinO AntigensComplement Pathway Mannose-Binding LectinHafnia alveiSerum Albumin BovineOligosaccharideComplement systemEndotoxinschemistryBiochemistryLectin pathwaybiology.proteinCattleFicolinGlycobiology
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Improved noninvasive prediction of liver fibrosis by liver stiffness measurement in patients with nonalcoholic fatty liver disease accounting for con…

2016

Background and aims: Liver stiffness measurement (LSM) frequently overestimates the severity of liver fibrosis In Nonalcoholic Fatty Liver Disease (NAFLD). Controlled Attenuation Parameter (CAP) is a new parameter provided by the same machine used for LSM, and associated with both steatosis and BMI, the two factors mostly affecting LSM peformance in NAFLD. We aimed to determine wheter prediction of liver fibrosis by LSM in NAFLD patients is affected by CAP values. Methods: Patients (n=324) were assessed by clinical and histological (Kleiner score) features. LSM and CAP were performed using the M probe. CAP values were grouped by tertiles (lower from 132 to 298, middle from 299 to 338, highe…

Liver CirrhosisAdultMalemedicine.medical_specialtyLiver CirrhosiPredictive Value of TestSex FactorBiologyGastroenterologyRisk AssessmentSensitivity and SpecificityCohort Studies03 medical and health sciencesSex Factors0302 clinical medicineElasticity Imaging TechniquePredictive Value of TestsLiver stiffnessFibrosisNon-alcoholic Fatty Liver DiseaseInternal medicineNonalcoholic fatty liver diseaseBiopsymedicineHumansIn patientAge FactorMultivariate AnalysiAgedAnalysis of Variancemedicine.diagnostic_testHepatologyBiopsy NeedleAge FactorsHepatologyMiddle Agedmedicine.diseaseImmunohistochemistryQuality ImprovementROC Curve030220 oncology & carcinogenesisPredictive value of testsMultivariate AnalysisElasticity Imaging Techniques030211 gastroenterology & hepatologyFemaleSteatosisCohort StudieHuman
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Fibronectin Type III Domain–Containing Protein 5 rs3480 A>G Polymorphism, Irisin, and Liver Fibrosis in Patients With Nonalcoholic Fatty Liver Dis…

2017

Context Contrasting data have been reported on the role of irisin, a novel myokine encoded by the fibronectin type III domain-containing protein 5 (FNDC5) gene, in nonalcoholic fatty liver disease (NAFLD) pathogenesis. We tested in patients with suspected nonalcoholic steatohepatitis (NASH) the association of FNDC5 variants, hepatic expression, and circulating irisin with liver damage (F2 to F4 fibrosis as main outcome). We also investigated whether irisin modulates hepatocellular fat accumulation and stellate cell activation in experimental models. Methods We considered 593 consecutive patients who underwent liver biopsy for suspected NASH and 192 patients with normal liver enzymes and wit…

Liver CirrhosisMale0301 basic medicineEndocrinology Diabetes and MetabolismClinical BiochemistrySeverity of Illness IndexBiochemistryGastroenterologyMiceEndocrinologyNon-alcoholic Fatty Liver DiseaseFibrosisNonalcoholic fatty liver diseaseOdds RatioProspective StudiesCarbon Tetrachloridemedicine.diagnostic_testReverse Transcriptase Polymerase Chain ReactionHep G2 CellsMiddle AgedFNDC5LiverLiver biopsyFemaleAdultmedicine.medical_specialtyIn Vitro TechniquesDiet High-FatReal-Time Polymerase Chain ReactionPolymorphism Single Nucleotide03 medical and health sciencesDiabetes mellitusInternal medicineMyokineHepatic Stellate CellsmedicineAnimalsHumansFNDC5 IRISIN NAFLDGenetic Predisposition to Diseasebusiness.industryBiochemistry (medical)medicine.diseasedigestive system diseasesFibronectins030104 developmental biologyEndocrinologyCase-Control StudiesHepatic stellate cellSteatosisbusinessThe Journal of Clinical Endocrinology & Metabolism
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Diagnostic accuracy of non-invasive tests for advanced fibrosis in patients with NAFLD : an individual patient data meta-analysis

2021

ObjectiveLiver biopsy is still needed for fibrosis staging in many patients with non-alcoholic fatty liver disease. The aims of this study were to evaluate the individual diagnostic performance of liver stiffness measurement by vibration controlled transient elastography (LSM-VCTE), Fibrosis-4 Index (FIB-4) and NAFLD (non-alcoholic fatty liver disease) Fibrosis Score (NFS) and to derive diagnostic strategies that could reduce the need for liver biopsies.DesignIndividual patient data meta-analysis of studies evaluating LSM-VCTE against liver histology was conducted. FIB-4 and NFS were computed where possible. Sensitivity, specificity and area under the receiver operating curve (AUROC) were c…

Liver CirrhosisMaleCirrhosisLIVER STIFFNESS MEASUREMENTBiopsy[SDV]Life Sciences [q-bio]biostatisticsGastroenterologyDISEASEbiostatistics; clinical decision making; fatty liver; hepatic fibrosis0302 clinical medicineNon-alcoholic Fatty Liver DiseaseFibrosishepatic fibrosis2. Zero hunger0303 health sciencesmedicine.diagnostic_testNONALCOHOLIC STEATOHEPATITISTRANSIENT ELASTOGRAPHYFatty liverGastroenterologyCHRONIC HEPATITISMiddle Aged3. Good healthSettore AGR/03 - Arboricoltura Generale E Coltivazioni ArboreeLiverLiver biopsyBIOPSYElasticity Imaging TechniquesFemale030211 gastroenterology & hepatologyMedian bodymedicine.medical_specialtyCONTROLLED ATTENUATION PARAMETER610 Medicine & healthclinical decision making03 medical and health sciencesInternal medicineSCOREmedicineHumansbiostatistics clinical decision making fatty liver hepatic fibrosisfatty liver030304 developmental biologyReceiver operating characteristicbusiness.industrymedicine.diseaseFibrosisDiabetes Mellitus Type 2XL PROBEbusinessHepatic fibrosisTransient elastographyBiomarkersPROSPECTIVE DERIVATIONGut : the journal of the British Society for Gastroenterology
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Early changes in dynamic biomarkers of liver fibrosis in hepatitis C virus-infected patients treated with sofosbuvir

2016

Abstract Background Chronic hepatitis C is a major cause of liver-associated mortality caused by decompensated cirrhosis and hepatocellular carcinoma. With the approval of sofosbuvir, therapeutic efficacy has markedly increased. Early changes in non-invasive biomarkers of liver fibrosis under effective antiviral therapy are widely unknown. Aim To evaluate early changes of fibrosis markers determined by enhanced liver fibrosis (ELF) scores and liver stiffness measurement (FibroScan®) in patients treated with sofosbuvir. Methods A total of 32 hepatitis C patients treated prospectively with sofosbuvir were included. The ELF-panel and FibroScan measurements were performed at baseline, week 4, e…

Liver CirrhosisMaleNon-invasive serum markersmedicine.medical_specialtySofosbuvirLiver fibrosisHepatitis C virusLiver fibrosisHepacivirusmedicine.disease_causeAntiviral AgentsGastroenterology03 medical and health sciences0302 clinical medicineFibrosisInternal medicinemedicineHumansAspartate AminotransferasesProspective StudiesLiver stiffness measurementHepatitisFibroScanHepatologymedicine.diagnostic_testbusiness.industryGastroenterologyHepatitis CHepatitis C ChronicMiddle AgedViral Loadmedicine.diseaseTreatment OutcomeELF030220 oncology & carcinogenesisLiver biopsyHepatocellular carcinomaElasticity Imaging TechniquesRNA ViralFemale030211 gastroenterology & hepatologySofosbuvirbusinessmedicine.drugDigestive and Liver Disease
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Early menopause is associated with lack of response to antiviral therapy in women with chronic hepatitis C.

2011

Background & Aims Chronic hepatitis C (CHC) and liver fibrosis progress more rapidly in men and menopausal women than in women of reproductive age. We investigated the associations among menopause, sustained virologic response (SVR), and liver damage in patients with CHC. Methods We performed a prospective study of 1000 consecutive, treatment-naive patients 18 years of age and older with compensated liver disease from CHC. Liver biopsy samples were analyzed (for fibrosis, inflammation, and steatosis) before patients received standard antiviral therapy. From women (n = 442), we collected data on the presence, type, and timing of menopause; associated hormone and metabolic features; serum lev…

Liver CirrhosisMaleTime Factorsmedicine.medical_treatmentBiopsyMenopause PrematuremenopauseHepacivirusmedicine.disease_causeGastroenterologySeverity of Illness IndexRisk FactorsOdds RatioProspective StudiesTreatment FailureProspective cohort studymedicine.diagnostic_testGastroenterologyAge FactorsHormone replacement therapy (menopause)Hepatitis CMiddle AgedViral LoadImmunohistochemistryMenopauseItalyLiver biopsyRNA ViralFemaleInflammation Mediatorshcv svr menopauseViral loadAdultmedicine.medical_specialtyantiviral therapy; menopause; prognostic factors; hcv therapyGenotypeHepatitis C virusAntiviral AgentsRisk AssessmentSex FactorsInternal medicinehcvmedicineHumanshcv; ifn; menopauseHepatologybusiness.industryInterleukin-6Tumor Necrosis Factor-alphaOdds ratioHepatitis C Chronicmedicine.diseaseifnEndocrinologyLogistic ModelsbusinessBiomarkersGastroenterology
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Non-invasive prediction of esophageal varices by stiffness and platelet in non-alcoholic fatty liver disease cirrhosis.

2018

Background & Aims: Baveno VI and expanded Baveno VI criteria can avoid the need for esophagogastroduodenoscopy (EGD) to screen for varices needing treatment (VNT) in a substantial proportion of compensated patients with viral and/or alcoholic cirrhosis. This multicenter, cross-sectional study aims to validate these criteria in patients with compensated cirrhosis due to non-alcoholic fatty liver disease (NAFLD), accounting for possible differences in liver stiffness measurement (LSM) values between M and XL probes. Methods: We assessed 790 patients with NAFLD-related compensated cirrhosis who had EGD within six months of a reliable LSM, measured by FibroScan® using M and/or XL probe. Baveno …

Liver CirrhosisMalemedicine.medical_specialtyAlcoholic liver diseaseCirrhosisVariceEsophageal and Gastric VaricesGastroenterology03 medical and health sciences0302 clinical medicineEsophageal varicesBaveno; Cirrhosis; NAFLD; Stiffness; Varices; Aged; Cross-Sectional Studies; Elasticity Imaging Techniques; Endoscopy Digestive System; Esophageal and Gastric Varices; Female; Humans; Liver Cirrhosis; Male; Middle Aged; Non-alcoholic Fatty Liver Disease; Platelet CountNon-alcoholic Fatty Liver DiseaseInternal medicineNAFLDmedicineHumansEndoscopy Digestive SystemBavenoScreening proceduresAgedCirrhosimedicine.diagnostic_testHepatologyEsophagogastroduodenoscopybusiness.industryPlatelet CountFatty liverHepatologyMiddle Agedmedicine.disease3. Good healthCross-Sectional Studies030220 oncology & carcinogenesisStiffneElasticity Imaging Techniques030211 gastroenterology & hepatologyFemaleVaricesbusinessJournal of hepatology
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Is Transient Elastography Needed for Noninvasive Assessment of High-Risk Varices? The REAL Experience

2019

INTRODUCTION: The Baveno VI consensus guidelines and an expanded algorithm suggest that transient elastography (TE) and platelet (PLT) count can be used to identify patients with cirrhosis who can avoid esophagogastroduodenoscopy (EGD). The primary aims of this study were to assess the ability of a simple algorithm, which uses only laboratory parameters, to predict medium/large esophageal varices (EV) in patients with hepatitis C virus (HCV) and cirrhosis from the Rete Sicilia Selezione Terapia-HCV (RESIST-HCV) cohort and to compare the performance of the algorithm with Baveno VI and Expanded Baveno VI criteria. The secondary aim was to assess the role of TE in ruling out large EV. METHODS:…

Liver CirrhosisMalemedicine.medical_specialtyCirrhosisBAVENO VI CRITERIA PORTAL-HYPERTENSION CONSENSUS WORKSHOP LIVER STIFFNESS PLATELET COUNT CIRRHOSIS DIAGNOSIS;Esophageal and Gastric Varices03 medical and health sciences0302 clinical medicineRESIST-HCVmedicineesophageal varicesHumansBaveno VIEndoscopy Digestive SystemSerum AlbuminAgedHepatologymedicine.diagnostic_testPlatelet CountEsophagogastroduodenoscopybusiness.industryfungiGastroenterologyReproducibility of Resultsfood and beveragesHepatitis C ChronicMiddle Agedmedicine.diseasetransient elastographyEndoscopyLogistic ModelsCIRRHOSIS PORTAL HYPERTENSION VARICES STIFFNESS030220 oncology & carcinogenesistransient elastography esophageal varices HCV RESIST-HCV Baveno VIMultivariate AnalysisHCVElasticity Imaging TechniquesFemale030211 gastroenterology & hepatologyRadiologyGastrointestinal HemorrhagebusinessVaricesTransient elastographyAlgorithms
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