Search results for "FORMS"
showing 10 items of 668 documents
Biowaiver Monographs for Immediate-Release Solid Oral Dosage Forms: Folic Acid.
2018
This work presents a review of literature and experimental data relevant to the possibility of waiving pharmacokinetic bioequivalence studies in human volunteers for approval of immediate-release solid oral pharmaceutical forms containing folic acid as the single active pharmaceutical ingredient. For dosage forms containing 5 mg folic acid, the highest dose strength on the World Health Organization Essential Medicines List, the dose/solubility ratio calculated from solubility studies was higher than 250 mL, corresponding to a classification as "not highly soluble." Small, physiological doses of folic acid (≤320 μg) seem to be absorbed completely via active transport, but permeability data f…
Computational Fluid Dynamics Simulation of Hydrodynamics and Stresses in the PhEur/USP Disintegration Tester Under Fed and Fasted Fluid Characteristi…
2015
ABSTRACT: Disintegration of oral solid dosage forms is a prerequisite for drug dissolution and absorption and is to a large extent dependent on the pressures and hydrodynamic conditions in the solution that the dosage form is exposed to. In this work, the hydrodynamics in the PhEur/USP disintegration tester were investigated using computational fluid dynamics (CFD). Particle image velocimetry was used to validate the CFD predictions. The CFD simulations were performed with different Newtonian and non-Newtonian fluids, representing fasted and fed states. The results indicate that the current design and operating conditions of the disintegration test device, given by the pharmacopoeias, are n…
Influence of fluorine on the fiber resistance studied through the nonbridging oxygen hole center related luminescence
2013
The distribution of Non-Bridging Oxygen Hole Centers (NBOHCs) in fluorine doped optical fibers was investigated by confocal microluminescence spectroscopy, monitoring their characteristic 1.9 eV luminescence band. The results show that these defects are generated by the fiber drawing and their concentration further increases after c irradiation. The NBOHC concentration profile along the fiber provides evidence for an exponential decay with the fluorine content. This finding agrees with the role of fluorine in the fiber resistance and is discussed, from the microscopic point of view, by looking at the conversion mechanisms from strained bonds acting as precursors.
Scalable and effective multi-level entangled photon states: a promising tool to boost quantum technologies
2021
Abstract Multi-level (qudit) entangled photon states are a key resource for both fundamental physics and advanced applied science, as they can significantly boost the capabilities of novel technologies such as quantum communications, cryptography, sensing, metrology, and computing. The benefits of using photons for advanced applications draw on their unique properties: photons can propagate over long distances while preserving state coherence, and they possess multiple degrees of freedom (such as time and frequency) that allow scalable access to higher dimensional state encoding, all while maintaining low platform footprint and complexity. In the context of out-of-lab use, photon generation…
GW190412: Observation of a binary-black-hole coalescence with asymmetric masses
2020
LIGO Scientific Collaboration and Virgo Collaboration: et al.
New insights into black bodies
2012
Planck's law describes the radiation of black bodies. The study of its properties is of special interest, as black bodies are a good description for the behavior of many phenomena. In this work a new mathematical study of Planck's law is performed and new properties of this old acquaintance are obtained. As a result, the exact form for the locus in a color-color diagrams has been deduced, and an analytical formula to determine with precision the black body temperature of an object from any pair of measurements has been developed. Thus, using two images of the same field obtained with different filters, one can compute a fast estimation of black body temperatures for every pixel in the image…
Complex singularities and PDEs
2015
In this paper we give a review on the computational methods used to capture and characterize the complex singularities developed by some relevant PDEs. We begin by reviewing the classical singularity tracking method and give an example of application using the Burgers equation as a case study. This method is based on the analysis of the Fourier spectrum of the solution and it allows to determine and characterize the complex singularity closest to the real domain. We then introduce other methods generally used to detect the hidden singularities. In particular we show some applications of the Padé approximation, of the Kida method, and of Borel-Polya method. We apply these techniques to the s…
Formulation predictive dissolution (fPD) testing to advance oral drug product development: an introduction to the US FDA funded ‘21st Century BA/BE’ …
2018
Over the past decade, formulation predictive dissolution (fPD) testing has gained increasing attention. Another mindset is pushed forward where scientists in our field are more confident to explore the in vivo behavior of an oral drug product by performing predictive in vitro dissolution studies. Similarly, there is an increasing interest in the application of modern computational fluid dynamics (CFD) frameworks and high-performance computing platforms to study the local processes underlying absorption within the gastrointestinal (GI) tract. In that way, CFD and computing platforms both can inform future PBPK-based in silico frameworks and determine the GI-motility-driven hydrodynamic impac…
Oral biopharmaceutics tools – Time for a new initiative – An introduction to the IMI project OrBiTo
2013
OrBiTo is a new European project within the IMI programme in the area of oral biopharmaceutics tools that includes world leading scientists from nine European universities, one regulatory agency, one non-profit research organization, four SMEs together with scientists from twelve pharmaceutical companies. The OrBiTo project will address key gaps in our knowledge of gastrointestinal (GI) drug absorption and deliver a framework for rational application of predictive biopharmaceutics tools for oral drug delivery. This will be achieved through novel prospective investigations to define new methodologies as well as refinement of existing tools. Extensive validation of novel and existing biopharm…
The design and implementation of Neuma, a collaborative Digital Scores Library - Requirements, architecture, and models
2012
This paper presents the design and implementation of the Neuma platform, a digital library devoted to the preservation and dissemination of symbolic music content (scores). Neuma is open to musicologists, musicians, and music publishers. It consists of a repository dedicated to the storage of large collections of digital scores, where users/applications can upload their documents. It also proposes services to publish, annotate, query, transform, and analyze scores. The long-term goal of the project is to enable an open and collaborative space where musician communities will be able to share music in symbolic notation. The project is organized around the French IRPMF institute (BnF–CNRS) whi…