Search results for "FORMS"
showing 10 items of 668 documents
Governance forms drivers in bio-pharmaceutial inter-firm relationships
2012
Networking benefits are acknowledged by many studies in the industrial organization and strategic management fields; transaction cost theory agency and property right theory provide the economic foundations to the market-hierarchy dilemma; while Resource based-view (RBV), relational and evolutionary theories provide the strategic foundation of the inter-firm relationships. All this theoretical strands investigate reasons that push firms to formalize their relationship in different governance structures. The bio-pharmaceutical industry has the characteristics to offer to the potential partners both exploitation or exploration alliances benefits. In particular some elements play a “pivot” rol…
Epigenetic activation of a cryptic TBC1D16 transcript enhances melanoma progression by targeting EGFR
2015
Metastasis is respoMetastasis is responsible for most cancer-related deaths, and, among common tumor types, melanoma is one with great potential to metastasize. Here we study the contribution of epigenetic changes to the dissemination process by analyzing the changes that occur at the DNA methylation level between primary cancer cells and metastases. We found a hypomethylation event that reactivates a cryptic transcript of the Rab GTPase activating protein TBC1D16 (TBC1D16-47 kDa; referred to hereafter as TBC1D16-47KD) to be a characteristic feature of the metastatic cascade. This short isoform of TBC1D16 exacerbates melanoma growth and metastasis both in vitro and in vivo. By combining imm…
Cadmium effects on p38/MAPK isoforms in MDA-MB231 breast cancer cells
2009
Emerging evidence seems to indicate that the heavy metal cadmium (Cd) is able to regulate gene expression, drastically affecting the pattern of transcriptional activity in normal and pathological eukaryotic cells, also affecting intracellular signalization events. Human p38 is a family of mitogen-activated protein kinases consisting of four isoforms (alpha, beta, gamma and delta) which mediate signal transduction cascades controlling several aspects of cell physiology. In this study we examined whether exposure of MDA-MB231 tumor cells from the human breast to Cd may exert some effect on p38 isoform expression and accumulation, as well as on p38 activation. Employing a combination of prolif…
Synthetic retinoids dissociate coactivator binding from corepressor release.
2002
The ligand-activated retinoid receptors RXR and RAR control development, homeostasis and disease by regulating transcription of retinoic acid (RA) responsive target genes or crosstalk with other signalling pathways. According to the current model ligand-binding triggers an exchange between corepressor- and coactivator-complexes that inhibit or potentiate transcription by deacetylating and acetylating nucleosomal histones, respectively. Additional cofactors may modify the transcriptional regulatory process by linking liganded retinoid receptors to structural components of chromatin or protein degradation. The desire to specifically influence defined events in RA-signalling, while others are …
Keyhole Limpet Hemocyanin Type 2 (KLH2): Detection and Immunolocalization of a Labile Functional Unit h
2000
Keyhole limpet hemocyanin (KLH) is a mixture of two hemocyanin isoforms, termed KLH1 and KLH2. Within KLH1 eight oxygen-binding functional units (FUs), 1-a to 1-h, have been identified, in contrast to KLH2, which was previously thought to be organized in seven FUs (2-a to 2-g). By limited proteolysis of KLH2 subunits, isolation of the polypeptide fragments, and N-terminal sequencing, we have now identified an eighth FU of type h, with a molecular mass of 43 kDa. This is unusually small for a FU h from a gastropodan hemocyanin. It is also shown that KLH2 didecamers can be split into a stable and homogeneous population of decamers by dialysis against 50 mM Tris/HCl, pH 7.5, in the absence of …
Sediment-flow interactions and effects on bed forms mechanism
2009
Recent experimental works conducted in mobile bed rectilinear flume seem to verify the existence of a correspondence between the spatial periodicity of horizontal turbulent structures evolving in streamwise direction and the wavelength of bed forms (alternate bars) observed on the bed. In this study, the effect of the variation of the bed roughness conditions on the evolution of such horizontal turbulent structures is analyzed. Peculiar results obtained by using flow velocity data collected along the flume both with flat bed and with deformed bed are reported.
On the conversation between female videobloggers and commentators
2021
El desarrollo de YouTube como una plataforma social surge a partir de dos ideas. En primer lugar, los amateurs pueden producir contenido de cualquier índole. Y, en segundo lugar, su audiencia puede expresar su opinión sin restricciones. Este intercambio de información impulsa la formación de comunidades en torno a un interés común: contenido y/o videobloguero. La dimensión social en YouTube tiene lugar de manera bidireccional. La interacción regular entre las dos partes ha significado un cambio crucial en la percepción de la producción y consumo audiovisual, así como también en los productores de vídeo, amateurs y audiencia. Las investigaciones iniciales se han dirigido a examinar los comen…
Impacts écologiques des formes d'urbanisation : modélisations urbaines et paysagères
2015
The global increase of urbanization during the past decades have induced a progressive artificialization of natural environments. The building of transport infrastructures and new housings causes a landscape fragmentation in an irreversible way and a strong decrease of the connectivity of ecological habitats. Maintaining the functionality of ecological networks is becoming a major goal of sustainable urban planning policies. With a special focus on urban evolutions in the horizon 2030 in the urban area of Besançon in eastern France (residential development and road traffic evolutions), this thesis aims to assess the potential impact of urban forms on landscape connectivity of animal species…
A normative planning approach for the Luxembourg : assessment based on spatial simulation
2015
In Luxembourg, daily mobility patterns of both cross-border workers and residents lead to a strong car dependance. This process encourages urban sprawl. Meanwhile the country is faced to increasing housing needs but has to reduce land consumption. Within this context, the main objective of this thesis is to throw light about the relation between residential growth patterns and daily mobility behaviors. In this way, a normative planning approach has been adopted. This approach proposes new planning norms for achieving a series of planning objectives. Quantitative rules are the tools used to apply the norms.Three steps has been done: i) conception of residential growth scenarios for 2030. By …
Sensitivity of a climate model to urban form : application on Dijon Métropole
2020
The urban environment is at the crossroads of two complex systems with different temporalities : climate and society. The urban climate is a modification of the climate caused by the presence of a city. The most successful expression of this climate change by the presence of the city is the phenomenon of Urban Heat Island (UHI). In a global context of adaptation and mitigation to climate change and urban development, this phenomenon of ICU tends to increase, and its health impacts on populations to become more prominent. This work is aimed at improving the knowledge of the impact of urban form and urban development on the intensity of the UCI through the implementation of a decision support…