Search results for "FORMS"

Klasiskie retorikas līdzekļi iedarbīgā mūsdienu publiskā runā

2015

Šī bakalaura darba tēma ir „Klasiskie retorikas līdzekļi iedarbīgā mūsdienu publiskā runā”. Veicot šo pētījumu, darba autore, pirmkārt, vēlas noskaidrot, vai tie retoriskie līdzekļi, kurus atklājuši tādi antīkie retorikas pētnieki kā Aristotelis, Cicerons un Kvintiliāns, joprojām ir aktuāli mūsdienās un, otrkārt, pievērst uzmanību šo instrumentu lietojuma biežumam pārliecinošā mūsdienu publiskā runā. Izmantotās pētījuma metodes ir apkopojoša analīze teorētiskajā daļā un diskursa kvalitatīva analīze empīriskajā daļā. Pētījuma rezultāti parāda, ka klasiskie retorikas līdzekļi joprojām ir piemērojami mūsdienu runām, un, lai pārliecinātu klausītājus, tie tiek bieži pielietoti mūsdienās.

EXPERIMENTAL ANALYSIS OF RELATION BETWEEN COHERENT TURBULENT STRUCTURES AND BED-FORMS FORMATION

2008

The present paper describes an experimental investigation on the interactions between flow turbulence and sediment motion. During the experiments, detailed measures of flow velocity components have been carried out using an Acoustic Doppler Velocimeter (ADV). The occurrence of turbulent events (inward interaction, ejection, sweep and burst) has been verified through the conditioned quadrant analysis. The quantitative information about the spatial and temporal evolution of turbulent events has been obtained through the space-time correlations of the conditioned data. As the primary objective was to analyse how turbulent structures influence the bed-forms formation, the spatial scale of turbu…

Chemical gels of scleroglucan obtained by cross-linking with 1,w-dicarboxylic acids: Synthesis and characterization

2005

Chemical gels obtained by cross-linking reaction between scleroglucan and I, omega-dicarboxylic acids having a number of carbon atoms from 4 to 8 in the chain, have been prepared and characterised. The networks show properties correlated with the number of carbon atoms of the acid and with the molar ratio carboxylic acid/glucose unit of the polymer (r) employed in the cross-linking reaction. The diffusion of theophylline, chosen as model drug, through the swelled cross-linked polymers has been also investigated and it has enabled the diffusion coefficients of the drug to be calculated under different environmental conditions. The release profiles of theophylline from tablets prepared with t…

Controlled cleavage of KLH1 and KLH2 by the V8 protease from Staphylococcus aureus reassociation, electrophoretic and transmission electron microscop…

1999

The reassociation behaviour of protease V8-cleaved peptides from KLH1 and KLH2, the two hemocyanin isoforms from the giant keyhole limpet Megathura crenulata, has been studied by transmission electron microscopy of negatively stained specimens and SDS/PAGE. Reassociation of the complete mixture of protease cleavage products and of combinations of peptide fragments purified by HPLC was performed in the presence of 100 mm CaCl2 and 100 mm MgCl2 at pH 7.4, over a period of 1 to 4 weeks. The V8 protease splits KLH1 into peptide fragments containing the functional units abc, def, defg, defgh, g and h. This mixture of peptide fragments reassociated to form helical tubular polymers, with a diamete…

Starzenie się mózgu a choroba Alzheimera

2014

Role of epigenetic factors in the selection of the alternative splicing isoforms of human

2017

Mutation-driven activation of KRAS is crucial to cancer development. The human gene yields four mRNA splicing isoforms, 4A and 4B being translated to protein. Their different properties and oncogenic potential have been studied, but the mechanisms deciding the ratio 4A/4B are not known. To address this issue, the expression of the four KRAS isoforms was determined in 9 human colorectal cancer cell lines. HCT116 and SW48 were further selected because they present the highest difference in the ratio 4A/4B (twice as much in HCT116 than in SW48). Chromatin structure was analysed at the exon 4A, characteristic of isoform 4A, at its intronic borders and at the two flanking exons. The low nucleoso…

Effects of cold acclimation and dsRNA injections on Gs1l gene splicing in Drosophila montana

2017

Abstract Alternative splicing, in which one gene produce multiple transcripts, may influence how adaptive genes respond to specific environments. A newly produced transcriptome of Drosophila montana shows the Gs1-like (Gs1l) gene to express multiple splice variants and to be down regulated in cold acclimated flies with increased cold tolerance. Gs1l’s effect on cold tolerance was further tested by injecting cold acclimated and non-acclimated flies from two distantly located northern and southern fly populations with double stranded RNA (dsRNA) targeting Gs1l. While both populations had similar cold acclimation responses, dsRNA injections only effected the northern population. The nature of …

Integrin α2β1 Mediates Isoform-Specific Activation of p38 and Upregulation of Collagen Gene Transcription by a Mechanism Involving the α2 Cytoplasmic…

1999

Two collagen receptors, integrins alpha1beta1 and alpha2beta1, can regulate distinct functions in cells. Ligation of alpha1beta1, unlike alpha2beta1, has been shown to result in recruitment of Shc and activation of the Ras/ERK pathway. To identify the downstream signaling molecules activated by alpha2beta1 integrin, we have overexpressed wild-type alpha2, or chimeric alpha2 subunit with alpha1 integrin cytoplasmic domain in human osteosarcoma cells (Saos-2) lacking endogenous alpha2beta1. The chimeric alpha2/alpha1 chain formed a functional heterodimer with beta1. In contrast to alpha2/alpha1 chimera, forced expression of alpha2 integrin resulted in upregulation of alpha1 (I) collagen gene …

Deregulated Splicing Is a Major Mechanism of RNA-Induced Toxicity in Huntington's Disease.

2019

Huntington's disease (HD) is caused by an expanded CAG repeat in the huntingtin (HTT) gene, translating into an elongated polyglutamine stretch. In addition to the neurotoxic mutant HTT protein, the mutant CAG repeat RNA can exert toxic functions by trapping RNA-binding proteins. While few examples of proteins that aberrantly bind to mutant HTT RNA and execute abnormal function in conjunction with the CAG repeat RNA have been described, an unbiased approach to identify the interactome of mutant HTT RNA is missing. Here, we describe the analysis of proteins that preferentially bind mutant HTT RNA using a mass spectrometry approach. We show that (I) the majority of proteins captured by mutant…

Systematic derivation of partial differential equations for second order boundary value problems

2022

Software systems designed to solve second order boundary value problems are typically restricted to hardwired lists of partial differential equations. In order to come up with more flexible systems, we introduce a systematic approach to find partial differential equations that result in eligible boundary value problems. This enables one to construct and combine one's own partial differential equations instead of choosing those from a pre-given list. This expands significantly end users possibilities to employ boundary value problems in modeling. To introduce the main ideas we employ differential geometry to examine the mathematical structure involved in second order boundary value problems …