Search results for "FORMS"

Receptor for advanced glycation end products is subjected to protein ectodomain shedding by metalloproteinases.

2008

The receptor for advanced glycation end products (RAGE) is a 55-kDa type I membrane glycoprotein of the immunoglobulin superfamily. Ligand-induced up-regulation of RAGE is involved in various pathophysiological processes, including late diabetic complications and Alzheimer disease. Application of recombinant soluble RAGE has been shown to block RAGE-mediated pathophysiological conditions. After expression of full-length RAGE in HEK cells we identified a 48-kDa soluble RAGE form (sRAGE) in the culture medium. This variant of RAGE is smaller than a 51-kDa soluble version derived from alternative splicing. The release of sRAGE can be induced by the phorbol ester PMA and the calcium ionophore c…

Type II keratin cDNAs from the rainbow trout: implications for keratin evolution.

2002

From a teleost fish, the rainbow trout Oncorhynchus mykiss, we have cloned and sequenced cDNAs encoding five different type II keratins. The corresponding protein spots, as separated by 2D-PAGE of trout cytoskeletal preparations, have been identified by peptide mass mapping using MALDI mass spectrometry. Three of the sequenced keratins are expressed in the epidermis (subtype IIe), and two in simple epithelia and mesenchymal cells (subtype IIs). The IIs keratins are both orthologs of human K8. This leaves unsequenced only the trace component S3 of the biochemically established trout keratin catalog. A phylogenetic tree has been constructed from a multiple alignment of the rod domains of the …

Ocular gelling microspheres: in vitro precorneal retention time and drug permeation through reconstituted corneal epithelium.

2008

Purpose: The model drug norfloxacin (NOR)was encapsulated into trehalose (TRH) and hydroxyethylcellulose(NAT) microspheres to obtain a novel gelling ophthalmic delivery system for prolonged release on corneal tissue. Methods: We assessed NOR release from microspheres, prepared by the emulsion-solvent evaporation method. A new in vitro tear turnover model, including inserts containing reconstituted human corneal epithelium (RHC), was designed to evaluate the TRH/NAT microspheres’ precorneal retention time. Bioadhesive properties of TRH/NAT microspheres were validated by using drug-loaded microspheres prepared with gelatine (GLT) commonly used as reference material in adhesion studies. Result…

A geomorphological approach for enhancing environmental management and conservation of landforms as protected nature objects in the Upper Daugava spi…

2015

<p class="R-AbstractKeywords"><span lang="EN-GB">This paper describes the application of geomorphological approach for environmental management and conservation of landforms. Specifically, we discuss the contribution of geomorphological field survey and adapted matrix methodology (in combination with understanding of geology) to identification, study and evaluation of those abiotic nature elements which represent geological and geomorphological heritage. We describe a case study carried out in that part of the protected landscape area “Augšdaugava” which encompasses the Upper Daugava spillway valley. The study programme reported in this paper was realized to perform inventory of…

Lasten kentät ja pääomat : osallistuminen ja eriarvoisuuksien rakentuminen päiväkodissa

2013

Effects of combined hormone replacement therapy or its effective agents on the IGF-1 pathway in skeletal muscle.

2010

Objectives To investigate the effects of combined hormone replacement therapy (HRT) and its effective agents on the IGF-1 signaling pathway. Design and methods To examine the effects of HRT on skeletal muscle in vivo, we utilized pre- and post-intervention samples from a randomized double blinded trial with 50–57-year-old women. The intervention included the year-long use of either HRT preparation (2 mg 17β-estradiol, E2; 1 mg norethisterone acetate, NETA, n = 10) or placebo (CO, n = 9). Microarray technology and quantitative PCR (qPCR) were used to study the expression of insulin-like growth factor I (IGF-1) and its splice variants as well as IGF-1 receptor, Akt1, mTOR, FOXO1, FOXO3, atrog…

Oral proficiency in second and third foreign languages in the Danish education system

2019

In this paper, we analyze how oral proficiency is understood in the Danish education system in the three biggest second/third foreign languages taught in the country: French, Spanish and German. We adopt a comparative perspective and analyze how orality is addressed in these language subjects at primary school, secondary school and university levels. We compare the three languages to find similarities and differences, focusing on learning objectives, pedagogical approaches and examination forms, presented in the official curricula for each of the three educational levels. We relate the Danish stance on oral proficiency to current international research in the field and to European tendencie…

Education in a crisis. Italy within southern Europe: Trends and the way forward

2016

El artículo analiza la reacción peculiar del sistema educativo italiano a la reciente crisis, en comparación con países dotados de un «modelo de bienestar Mediterráneo», como Grecia, Portugal y España. Analizando los principales indicadores estadísticos nacionales de los sistemas educativos –acceso a la educación, éxito escolar, equidad e inclusión de alumnos inmigrantes– se ha profundizado en las dificultades, pero también en la resiliencia del sistema italiano de educación. El análisis permite concluir que las prioridades en términos de reforma son: completar el proceso de autonomía escolar, completar el plan de digitalización, dotando todas las escuelas de TICs actualizadas, cambiar la j…

Introduction to Mathematical Logic (Edition 2017)

2017

Hyper-textbook for students in mathematical logic, Edition 2017

Humus forms, carbon stock and properties of soil organic matter in forests formed on dry mineral soils in Latvia

2020

Over the last decades, more attention has been paid to carbon accumulation in soil, more recently, to soil humus forms, as they indicate environmental conditions and state of soil organic matter. There is insufficient information on the impact of soil and forest type on the chemical properties of soil, soil organic matter and humus form. Knowledge about the chemical properties of humus is crucial for modelling C and N accumulation and storage in forest soils. On this account, the aim of this study was to characterize soil humus forms, humus chemical properties and C stock and to determine the spatial distribution correlations between soil humus forms in forests formed on dry mineral soils. …