Search results for "FP"

Effect of β-Blocker Withdrawal on Functional Capacity in Heart Failure and Preserved Ejection Fraction

2021

BACKGROUND Chronotropic incompetence has shown to be associated with a decrease in exercise capacity in heart failure with preserved ejection fraction (HFpEF), yet b-blockers are commonly used in HFpEF despite the lack of robust evidence. OBJECTIVES This study aimed to evaluate the effect of b-blocker withdrawal on peak oxygen consumption (peak VO2) in patients with HFpEF and chronotropic incompetence. METHODS This is a multicenter, randomized, investigator-blinded, crossover clinical trial consisting of 2 treatment periods of 2 weeks separated by a washout period of 2 weeks. Patients with stable HFpEF, New York Heart Association functional classes II and III, previous treatment with b-bloc…

Identification of a discrete neuronal circuit that relays insulin signaling into the brain to regulate glucose homeostasis

2021

Abstract26RFa (QRFP) is a biologically active peptide that regulates glucose homeostasis by acting as an incretin and by increasing insulin sensitivity at the periphery. 26RFa is also produced by a neuronal population localized in the hypothalamus. In the present study, we have investigated whether the 26RFa neurons may be involved in the hypothalamic regulation of glucose homeostasis. Our data indicate that 26RFa, i.c.v. injected, induces a robust antihyperglycemic effect associated with an increase of insulin production by the pancreatic islets. In addition, we found that insulin strongly stimulates 26RFa expression and secretion by the hypothalamus. RNAscope experiments revealed that neu…

The GALAD Score as Potential Screening Test for Hepatocellular Carcinoma in Nonalcoholic Steatohepatitis: An International Multicenter Study

2019

The prevalence of nonalcoholic steatohepatitis (NASH) is rising rapidly and is currently the most common chronic liver disease in Western populations. Hepatocellular carcinoma (HCC) is a major complication of NASH and the current performance of screening approaches based on ultrasound shows limitations. To facilitate earlier diagnosis, this international multicenter study, with eight German and one Japanese center participating, tests the potential benefit of applying the biomarkers AFP, AFP-L3, DCP and related scores for HCC screening in NASH patients. In the retrospective German cohort, 126 NASH patients with newly diagnosed HCC and 231 NASH control patients without HCC were enrolled. In …

Mise en œuvre d’une architecture de gestion de collision pour le déploiement efficace d’un NoC sur multi-FPGA

2015

International audience; Le déploiement d’un NoC (Network On Chip) sur plusieurs FPGA nécessite que des routeurs partagent un même lien de communication entre FPGAs, créant des goulots d’étranglement [1]. Dans ce papier, nous proposons une structure de gestion de collision intégrée entre le NoC et le point d’accès du protocole FPGA. Cette structure est basée sur les algorithmes utilisés dans les réseaux informatiques et adaptée aux NoC [2].

Tailored nanosized metal catalysts for improving activity and selectivity via engineering of their structure and local environment - NANOCAT PUBLISHA…

2008

Digitālās aparatūras projektēšanas un testēšanas tiešsaistes platforma

2022

Darba mērķis ir izstrādāt un analizēt tiešsaistes platformu digitālās aparatūras attīstītājrīku attālinātai pārvaldībai, programmaparatūras glabāšanai un šīs programmaparatūras attālinātai testēšanai platformā pieejamos attīstītājrīkos. Darbā tiek izstrādāta platforma, veikta platformas darbības mehānismu modelēšana, ap rakstīti sarežģījumi šādas platformas izstrādē, izstrādes laikā izmantotie risinājumi un to arhi tektūra. Precīzāk, tiek izstrādāta un aprakstīta vāja reāllaika attālinātas mijiedarbības realizācija starp platformas lietotājiem un digitālo aparatūru, tai skaitā attālināta aparatūras programmēša na, attālināta testēšana un attālināta izmantošana. Tiek aprakstītas, analizētas …

HDR-­ARtiSt: a FPGA-­based Smart Camera for High Dynamic Range color video from multiple exposures

2014

International audience; A camera is able to capture only a part of a high dynamic range scene information. The same scene can be fully perceived by the human visual system. This is true especially for real scenes where the difference in light intensity between the dark areas and bright areas is high. The imaging technique which can overcome this problem is called HDR (High Dynamic Range). It produces images from a set of multiple LDR images (Low Dynamic Range), captured with different exposure times. This technique appears as one of the most appropriate and a cheap solution to enhance the dynamic range of captured environments. We developed an FPGA-based smart camera that produces a HDR liv…

Estudio, diseño e integración de un sistema basado en FPGA para el cálculo del tiempo de vuelo aplicado a equipos PET

2014

La Medicina Nuclear ha experimentado avances significativos en los últimos años debido a la mejora en materiales, sistemas electrónicos, técnicas de algoritmia, de procesado etc., que han permitido que su aplicación se haya extendido considerablemente. Una de las técnicas que más ha progresado en este ámbito ha sido la Tomografía por Emisión de Positrones (PET, del inglés Positron Emission Tomography), consistente en un método no invasivo y muy útil para la evaluación de anomalías de tipo cancerosas. Este sistema está basado en un principio de toma de datos y procesado mediante el cual se obtienen imágenes de la distribución espacial y temporal de los procesos metabólicos que se generan en …

Predictive First-principles Modeling of a Photosynthetic Antenna Protein : The Fenna-Matthews-Olson Complex

2020

High efficiency of light harvesting in photosynthetic pigment-protein complexes is governed by evolutionary-perfected protein-assisted tuning of individual pigment properties and inter-pigment interactions. Due to the large number of spectrally overlapping pigments in a typical photosynthetic complex, experimental methods often fail to unambiguously identify individual chromophore properties. Here we report a first principles-based modeling protocol capable of predicting properties of pigments in protein environment to a high precision. The technique was applied to successfully uncover electronic properties of the Fenna-Matthews-Olson (FMO) pigment-protein complex. Each of the three subunit…

Power calculation of multi-band signals: design and implementation on FPGA

2017

International audience