Search results for "FRAGMENT"

showing 2 items of 1612 documents

Gotu valodas piemineklis Skeireins un tā raksturīgākās valodas savādības: studiju darbs

1933

Ģermāņu valodasSkeireins - Jāņa evaņģēlija komentāru fragmentiDiplomdarbiSkeireins - gotu valodas piemineklis:HUMANITIES and RELIGION::Religion/Theology::New Testament exegesis [Research Subject Categories]:HUMANITIES and RELIGION::Languages and linguistics::Other Germanic languages::Germanic languages [Research Subject Categories]Gotische SpracheGotu valodaSkeirein - Kommentarfragmente des Johannesevangeliums
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Profiling Dopamine-Induced Oxidized Proteoforms of β-synuclein by Top-Down Mass Spectrometry

2021

The formation of multiple proteoforms by post-translational modifications (PTMs) enables a single protein to acquire distinct functional roles in its biological context. Oxidation of methionine residues (Met) is a common PTM, involved in physiological (e.g., signaling) and pathological (e.g., oxidative stress) states. This PTM typically maps at multiple protein sites, generating a heterogeneous population of proteoforms with specific biophysical and biochemical properties. The identification and quantitation of the variety of oxidized proteoforms originated under a given condition is required to assess the exact molecular nature of the species responsible for the process under investigation…

β synucleinPhysiologyClinical BiochemistryContext (language use)RM1-950Mass spectrometryProtein oxidationBiochemistryArticlechemistry.chemical_compoundDopamine oxidationDopamineSettore BIO/10 - BiochimicamedicineTop-down mass spectrometryFragmentation (cell biology)Proteoforms relative quantitationMolecular BiologyHuman β-synucleinMethionineMethionine sulfoxideCell BiologychemistryBiochemistryTherapeutics. PharmacologyMethionine sulfoxidemedicine.drug
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