Search results for "FRAM"
showing 10 items of 2142 documents
Zebrafish as a Model to Evaluate a CRISPR/Cas9-Based Exon Excision Approach as a Future Treatment Option for EYS-Associated Retinitis Pigmentosa
2021
Retinitis pigmentosa (RP) is an inherited retinal disease (IRD) with an overall prevalence of 1 in 4000 individuals. Mutations in EYS (Eyes shut homolog) are among the most frequent causes of non-syndromic autosomal recessively inherited RP and act via a loss-of-function mechanism. In light of the recent successes for other IRDs, we investigated the therapeutic potential of exon skipping for EYS-associated RP. CRISPR/Cas9 was employed to generate zebrafish from which the region encompassing the orthologous exons 37-41 of human EYS (eys exons 40-44) was excised from the genome. The excision of these exons was predicted to maintain the open reading frame and to result in the removal of exactl…
Governance models of coopetition and innovation: the case of Spanish firms
2016
Although numerous studies show that cooperation relates strongly to obtaining benefits in business innovation, few researchers have considered the role of competition in this relationship. Nevertheless, it is expected that firms can boost their innovation if they cooperate with competitors and with intermediaries. The aim of this study was to observe whether coopeting firms achieve high degrees of innovation. To accomplish this aim, we used a sample of innovative firms from the region of Valencia (Spain). The chosen region has specific structural characteristics, which are discussed later. Although the sampled firms compete with one another, they also collaborate with each other and with in…
Receiving water quality assessment: comparison between simplified and detailed integrated urban modelling approaches
2010
Urban water quality management often requires use of numerical models allowing the evaluation of the cause–effect relationship between the input(s) (i.e. rainfall, pollutant concentrations on catchment surface and in sewer system) and the resulting water quality response. The conventional approach to the system (i.e. sewer system, wastewater treatment plant and receiving water body), considering each component separately, does not enable optimisation of the whole system. However, recent gains in understanding and modelling make it possible to represent the system as a whole and optimise its overall performance. Indeed, integrated urban drainage modelling is of growing interest for tools to …
Corresponsabilità e cura educativa dei genitori nello “zero-sei”: un’esperienza di ricerca e formazione attraversata dalla pandemia
2022
This paper focuses on early childhood educators as possible facilitators of educational co-responsibility with families and, therefore, of inclusive educating communities, in line with the PNRR. A research-training with educators from Palermo, which began before the pandemic and was then reformulated, is presented. For this research, a questionnaire was administered in 2019 to investigate three areas from which, according to the literature, obstacles to an effective educational alliance often arise: educators’ understanding of current family education, what educators think parents to be and ideas of co-responsibility. In 2022, an online questionnaire similar to the first was administered, a…
Quality assurance and assessment frameworks of Italian Biosystems Engineering studies
2010
In Italy the tools for quality assurance and assessment frameworks of all University studies are established by the D.M. (Law) of the Ministry of Education, University and Research n. 544 of the 31st October 2007, dealing with the requirements that Universities must have every year in order to offer degree study programs. Moreover, the accreditation procedure is established by the Law of the Italian Ministry of Work and Welfare n. 166 of the 25th May 2001, by which each Italian Regional administration can recognise the proposal and organisation of teaching activities (e.g. higher education) or guidance ones, funded by public resources, to public and/or private bodies (e.g. Universities). Th…
Observation ofe+e−→ρ+ρ−nears=10.58 GeV
2008
We report the first observation of e^+e^- → ρ^+ρ^-, in a data sample of 379 fb^(-1) collected with the BABAR detector at the PEP-II e+e- storage ring at center-of-mass energies near √s = 10:58 GeV. We measure a cross section of σ(e^+e^- → ρ^+ρ^-)= 8:3 ± 0:7(stat)± 0:8(syst) fb within the range of │cosθ^*│ < 0:8 and │ cosθ_±│ < 0:85, where θ^* is the center-of-mass polar angle of the ρ^± meson and θ_± are the angles in the ρ^± rest frame between the direction of the boost from the laboratory frame and the direction of the π^±. Assuming production through single-photon annihilation, there are three independent helicity amplitudes. We measure the ratios of their squared moduli to be │F_(00)│^2…
Comparison between two strictly local QCD sum rules
1989
Two strictly local QCD sum rules, analytic extrapolation by conformal mapping and analytic continuation by duality, are developed and presented in full detail. They allow the extrapolation of the QCD amplitude to a single point near zero in the complex {ital q}{sup 2} plane. Being orthogonal to the usual QCD sum rules, they present a drastic enlargement of phenomenological applications. In addition, the stability of both methods is shown explicitly, a fact which makes them particularly reliable. The difference between the two methods is illustrated in connection with the determination of the hadronic ({ital g}{minus}2) factor of the muon. Their effectiveness is demonstrated in the calculati…
Collision models in quantum optics
2017
AbstractQuantum collision models (CMs) provide advantageous case studies for investigating major issues in open quantum systems theory, and especially quantum non-Markovianity. After reviewing their general definition and distinctive features, we illustrate the emergence of a CM in a familiar quantum optics scenario. This task is carried out by highlighting the close connection between the well-known input-output formalism and CMs. Within this quantum optics framework, usual assumptions in the CMs’ literature - such as considering a bath of noninteracting yet initially correlated ancillas - have a clear physical origin.
Deep inelastic scattering on the quark-gluon plasma
2020
We provide an interpretation of the structure functions of a thermal medium such as the quark-gluon plasma in terms of the scattering of an incoming electron on the medium via the exchange of a spacelike photon. We then focus on the deep-inelastic scattering (DIS) regime, and formulate the corresponding moment sum rules obeyed by the structure functions. Accordingly, these moments are given by the thermal expectation value of twist-two operators, which is computable from first principles in lattice QCD for the first few moments. We also show how lattice QCD calculations can be used to probe how large the photon virtuality needs to be in order for the Bjorken scaling of structure functions t…
Neutrino masses and mixing: a flavour symmetry roadmap
2012
Over the last ten years tri-bimaximal mixing has played an important role in modeling the flavour problem. We give a short review of the status of flavour symmetry models of neutrino mixing. We concentrate on non-Abelian discrete symmetries, which provide a simple way to account for the TBM pattern. We discuss phenomenological implications such as neutrinoless double beta decay, lepton flavour violation as well as theoretical aspects such as the possibility to explain quarks and leptons within a common framework, such as grand unified models