Search results for "FS"
showing 10 items of 1992 documents
Xéno-hormone exposure during pregnancy and lactation modify sweet preference of male but not female offspring
2008
Long-Term Effects of Delayed Fatherhood in Mice on Postnatal Development and Behavioral Traits of Offspring1
2009
This study aims to analyze, in mice, the long-term effects of delayed fatherhood on postnatal development, spontaneous motor activity, and learning capacity of offspring. Hybrid parental-generation (F 0 ) males, at the age of 12, 70, 100, and 120 wk, were individually housed with a randomly selected 12wk-old hybrid female. The resulting first-generation (F 1 ) offspring were tested for several developmental and behavioral variables. Cumulative percentage of F 1 pups that attained immediate righting in the 120-wk group was lower than that found in the 12-, 70-, and 100-wk groups. Furthermore, the postnatal day of attaining immediate righting was higher in pups from the 120-wk group when comp…
Delayed Motherhood Decreases Life Expectancy of Mouse Offspring1
2005
Abstract This study analyzes the long-term effects of delayed motherhood on reproductive fitness and life expectancy of offspring in the mouse. Hybrid (C57BL/6JIco × CBA/JIco) first-generation (F1) females, either at the age of 10 or 51 wk, were individually housed with a randomly selected 12- to 14-wk-old hybrid male following a breeding pen system until females reached the end of their reproductive life. Reproductive fitness of second-generation (F2) females was tested from the age of 25 wk until the end of their reproductive life. In F2 males, the testing period ranged from the age of 52 wk until their natural death. Delayed motherhood of hybrid F1 female mice was associated with a decre…
Use of Spectroscopic Techniques to Monitor Changes in Food Quality during Application of Natural Preservatives: A Review
2020
Publisher's version (útgefin grein)
Runas izdalīšana audio ierakstos, izmantojot dziļo mašīnapmācību
2021
Kvalifikācijas darbā tiek aprakstīta sistēma, tās prasības un realizācija. Šī sistēma sastāv no tīmekļa vietnes un mašīnmācīšanās modeļa, ar kura palīdzību ir iespējams izdalīt runas fragmentus augšupielādētajā audio failā. Šī sistēma satur arī datu kopas sagatavošanas moduli, ar kura palīdzību tiek apkopoti dati no FSD50K kopas, un tie tiek sagatavoti priekš jau iepriekš apmācīta DenseNet modeļa pielāgošanas un apmācības. Rezultātā tika apmācīti vairāki modeļi, no kuriem tika atlasīts labākais, kurš pēc tam tika savienots ar tīmekļa vietni, ar kuras palīdzību ir iespējams iesniegt failu runas izdalīšanas analīzei un apskatīt atgriezto rezultātu lietotājam vienkāršā veidā.
Foreign Language Learners’ Pronunciation Learning Beliefs and Strategies
2021
This quantitative research investigates the extent to which adult L2 learners act in line with what they declare to believe in regarding pronunciation learning. In other words, this paper focuses on determining the strength of the relationship between the frequency of use of L2 pronunciation learning strategies (PLS) and the beliefs the individuals hold on selected factors affecting pronunciation acquisition, pronunciation instruction, self-efficacy, pronunciation learning goals and affective factors in pronunciation learning. A group of 116 learners of English as a foreign language who took an English phonetics course responded to the Pronunciation Learning Strategies Inventory (PLSI) and …
Characterizing the N-terminal processing motif of MHC class I ligands.
2008
Abstract Most peptide ligands presented by MHC class I molecules are the product of an intracellular pathway comprising protein breakdown in the cytosol, transport into the endoplasmic reticulum, and successive N-terminal trimming events. The efficiency of each of these processes depends on the amino acid sequence of the presented ligand and its precursors. Thus, relating the amino acid composition N-terminal of presented ligands to the sequence specificity of processes in the pathway gives insight into the usage of ligand precursors in vivo. Examining the amino acid composition upstream the true N terminus of MHC class I ligands, we demonstrate the existence of a distinct N-terminal proces…
The Role of Low Complexity Regions in Protein Interaction Modes: An Illustration in Huntingtin
2021
Low complexity regions (LCRs) are very frequent in protein sequences, generally having a lower propensity to form structured domains and tending to be much less evolutionarily conserved than globular domains. Their higher abundance in eukaryotes and in species with more cellular types agrees with a growing number of reports on their function in protein interactions regulated by post-translational modifications. LCRs facilitate the increase of regulatory and network complexity required with the emergence of organisms with more complex tissue distribution and development. Although the low conservation and structural flexibility of LCRs complicate their study, evolutionary studies of proteins …
Kinetic analysis and molecular modeling of the inhibition mechanism of roneparstat (SST0001) on human heparanase
2016
Heparanase is a β-d-glucuronidase which cleaves heparan sulfate chains in the extracellular matrix and on cellular membranes. A dysregulated heparanase activity is intimately associated with cell invasion, tumor metastasis and angiogenesis, making heparanase an attractive target for the development of anticancer therapies. SST0001 (roneparstat; Sigma-Tau Research Switzerland S.A.) is a non-anticoagulant 100% N-acetylated and glycol-split heparin acting as a potent heparanase inhibitor, currently in phase I in advanced multiple myeloma. Herein, the kinetics of heparanase inhibition by roneparstat is reported. The analysis of dose-inhibition curves confirmed the high potency of roneparstat (I…
A potential solution to avoid overdose of mixed drugs in the event of Covid-19: Nanomedicine at the heart of the Covid-19 pandemic.
2021
Since 2020, the world is facing the first global pandemic of 21st century. Among all the solutions proposed to treat this new strain of coronavirus, named SARS-CoV-2, the vaccine seems a promising way but the delays are too long to be implemented quickly. In the emergency, a dual therapy has shown its effectiveness but has also provoked a set of debates around the dangerousness of a particular molecule, hydroxychloroquine. In particular, the doses to be delivered, according to the studies, were well beyond the acceptable doses to support the treatment without side effects. We propose here to use all the advantages of nanovectorization to address this question of concentration. Using quantum…