Search results for "FTO"

Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to th…

2012

Background: Although the Fat Mass and Obesity (FTO) and Melanocortin-4 Receptor (MC4R) genes have been consistently associated with obesity risk, the association between the obesity-risk alleles with type 2 diabetes is still controversial. In some recent meta-analyses in which significant results have been reported, the associations disappeared after adjustment for body mass index (BMI). However gene-diet interactions with dietary patterns have not been investigated. Our main aim was to analyze whether these associations are modulated by the level of adherence to the Mediterranean Diet (MedDiet). Methods: Case-control study in 7,052 high cardiovascular risk subjects (3,430 type 2 diabetes c…

Novel genetic variant in FTO influences insulin levels and insulin resistance in severely obese children and adolescents.

2008

Background: The global prevalence of obesity and overweight is increasing rapidly among adults as well as among children and adolescents. Recent genome-wide association studies have provided strong support for association between variants in the FTO gene and obesity. We sequenced regions of the FTO gene to identify novel variants that are associated with obesity and related metabolic traits. Results: We screened exons 3 and 4 including exon-intron boundaries in FTO in 48 obese children and adolescents and identified three novel single nucleotide polymorphism in the fourth intronic region, (c.896 + 37A > G, c.896 + 117C > G and c.896 + 223A > G). We further genotyped c.896 + 223A > G in 962 …

Designing supplier selection strategies under COVID-19 constraints for industrial environments

2021

COVID-19 has been impacting worldwide supply chains causing interruption, closure of production and distribution. This impact has been drastic on the supplier side and, as a consequence of disruptions, strong reductions of production have been estimated. Such a circumstance forces companies to propose innovative best practices of supply chain risk management aimed at facing vulnerability generated by COVID-19 and pursuing industrial improvements in manufacturing and production environments. As a part of supply chain strategy, supplier selection criteria should be revised to include pandemic-related risks. This article aims to propose an answer to such a problem. In detail, a comprehensive t…

Optimizing the use of spineless cactus in the finishing diet of lambs: physicochemical properties and sensory characteristics of meat.

2019

BACKGROUND The use of spineless cactus in finishing diets for lambs improves the carcass quality. However, data about its influence on meat traits is very scarce. The effects of spineless cactus inclusion in the finishing diet of lambs at four levels (0, 150, 300 and 450 g kg-1 of dry matter, DM) in replacement of Tifton hay on the physicochemical and sensory properties of meat were studied. RESULTS The spineless cactus modified the chemical composition increasing the protein (P < 0.001) and the fat (P < 0.01) contents of meat, presenting the greatest values in lambs fed diets with 150 and 300 g kg-1 (DM) replacing levels, respectively. However, the spineless cactus did not influence the gr…

Celiachia. I Segnali Provenienti dalla Bocca

2013

Inhalable nano into micro dry powders for ivacaftor delivery: The role of mannitol and cysteamine as mucus-active agents.

2020

In this paper the innovative approach of Nano into micro (NiM9 was developed to produce Nanoparticles loaded Ivacaftor to incorporate into mannitol or mannitol/cysteamine micromatrices for drug pulmonary administration in CF. Nanoparticles composed by a mixture of two polyhydrohydroxyethtylaspartamide copolymers containing a loading of Ivacaftor of 15.5 % w/w were produced. These Nanoparticles were incorporated into microparticles to obtain NiM that were characterized in terms of size and size distribution, interaction with CF-AM by rheological and turbidimetric studies as well as by aerodynamic diameter measurements. Finally the activity of Ivacaftor into these NiM was evaluated by in vitr…

Reconfiguration strategies to reduce mismatch effects on PV array: An Arduino-based prototype

2014

Today, solar energy represents a widespread source of electricity among all the renewable energies. One of the major problems concerning the photovoltaic (PV) arrays is the partial shading, that is the non-uniform irradiance on its parts. The partial shading leads to several undesired effects, such as mismatch between modules and a reduction of the production of electric energy. In order to alleviate the partial shading effects, different methods can be employed. Among them, the reconfiguration of the electrical connections between modules represents an alternative solution. In this paper, an algorithm of reconfiguration for a small-scale PV plant is proposed and experimental results showin…

Manufacturing tolerances effects on PV array energy production

2014

This paper investigates the tolerance effects of commercial photovoltaic modules in terms of electrical energy reduction of photovoltaic plants. Several commercial modules, having the same rated power, present different power tolerance values. A wide tolerance is an indicator of possible defects or differences in the production process and is responsible of remarkable reductions in the electricity production of photovoltaic plants. In this paper, thanks to the development of a suitable simulation tool, several simulations have been carried out, considering different tolerance and shading conditions for the PV array. Simulation results quantify the peak power value of the different plant con…

A simple and accurate model of photovoltaic modules for power system design

2014

A combined multi-criteria approach to support FMECA analyses: A real-world case

2018

[EN] The paper proposes an approach that combines reliability analyses and multi-criteria decision methods to optimize maintenance activities of complex systems. A failure mode, effects, and criticality analysts (FMECA) is initially performed and the fuzzy TOPSIS (FTOPSIS) method is then applied to rank previously identified failure modes. For prioritization, failure modes are assessed against three evaluation criteria that differ from those traditionally involved in risk priority number (RPN) computation (i.e. severity, occurrence and detection). Two criteria refer to the maintenance management reflecting the operational time taken by the maintenance activity performed after the occurrence…