Search results for "FUNCTIONAL IMPAIRMENT"

Correlations Between Clinical Trial Outcomes Based on Symptoms, Functional Impairments, and Quality of Life in Children and Adolescents With ADHD

2017

Objective: To assess relationships between treatment-associated changes in measures of ADHD symptoms, functional impairments, and health-related quality of life in children and adolescents with ADHD. Method: Pearson correlation coefficients were calculated post hoc for changes from baseline to endpoint in outcomes of one randomized, placebo- and active-controlled trial of lisdexamfetamine (osmotic-release methylphenidate reference) and one of guanfacine extended-release (atomoxetine reference). Results: Changes in ADHD Rating Scale IV (ADHD-RS-IV) total score generally correlated moderately with changes in Child Health and Illness Profile−Child Edition: Parent Report Form (CHIP-CE:PRF) Ach…

Motivos para el consumo de cibersexo y su relación con el grado de severidad

2018

La práctica del cibersexo es un comportamiento frecuente que puede desembocar en un patrón de consumo compulsivo, incontrolado y asociado a un deterioro funcional en diversos ámbitos (adicción al cibersexo). Por tanto, conocer los motivos que explicarían que una persona realice esta conducta (de modo recreativo o patológico) es prioritario. Así, este trabajo se plantea el objetivo de analizar la prevalencia de distintos motivos para el consumo de cibersexo, las diferencias en función del género y el vínculo entre estos motivos y los síntomas de consumo problemático. Tomando una muestra de 400 jóvenes (50% hombres) de entre 18-30 años (M=22.2), se constata que las motivaciones más frecuentes…

The generalizability of Older Adult Self-Report (OASR) syndromes of psychopathology across 20 societies

2020

Contains fulltext : 217516.pdf (Publisher’s version ) (Closed access) Objectives: As the world population ages, psychiatrists will increasingly need instruments for measuring constructs of psychopathology that are generalizable to diverse elders. The study tested whether syndromes of co-occurring problems derived from self-ratings of psychopathology by US elders would fit self-ratings by elders in 19 other societies. Methods/design: The Older Adult Self-Report (OASR) was completed by 12 826 adults who were 60 to 102 years old in 19 societies from North and South America, Asia, and Eastern, Northern, Southern, and Western Europe, plus the United States. Individual and multigroup confirmatory…

Assessing physical performance and physical activity in large population-based aging studies: home-based assessments or visits to the research center?

2019

Abstract Background The current study aims to compare correlations between a range of measures of physical performance and physical activity assessing the same underlying construct in different settings, that is, in a home versus a highly standardized setting of the research center or accelerometer recording. We also evaluated the selective attrition of participants related to these different settings and how selective attrition affects the associations between variables and indicators of health, functioning and overall activity. Methods Cross-sectional analyses comprising population-based samples of people aged 75, 80, and 85 years living independently in Jyväskylä, Finland. The AGNES stud…

Body composition as a predictor of physical performance in older age : A ten- year follow-up of the Helsinki Birth Cohort Study

2018

Background: This study assessed how different measures of body composition predict physical performance ten years later among older adults. Methods: The participants were 1076 men and women aged 57 to 70 years. Body mass index (BMI), waist circumference, and body composition (bioelectrical impedance analysis) were measured at baseline and physical performance (Senior Fitness Test) ten years later. Linear regression analyses were adjusted for age, education, smoking, duration of the follow-up and physical activity. Results: Greater BMI, waist circumference, fat mass, and percent body fat were associated with poorer physical performance in both sexes (standardized regression coefficient [beta…

Are affective temperaments determinants of quality of life in euthymic patients with bipolar disorder?

2018

Background: Bipolar disorder (BD) is a disabling illness that is associated with low quality of life (QoL). This low QoL goes further than mood episodes, which suggests that stable traits, such as affective temperaments, can cause functional impairment. Objective: Our study analyses the impact of affective temperaments on the Physical Component Summary (PCS) and Mental Component Summary (MCS) of QoL in euthymic BD patients. Methods: A multicentre study was conducted in 180 euthymic BD patients and 95 healthy controls. Firstly, statistical analyses were performed to compare QoL and affective temperaments between the two groups. Secondly, Adaptive Lasso Analysis was carried out to identify th…

Funcionamiento neurocognitivo y psicosocial de pacientes con trastorno bipolar en una unidad de salud mental

2018

INTRODUCCION: Existe evidencia de que los pacientes que padecen Trastoro Bipolar (TB), e incluso sus familiares sanos, presentan patrones característicos de afectación de ciertos dominios neurocognitivos que persisten tras la remisión clínica o período de eutimia. La pérdida de funcionalidad psicosocial de estos pacientes se predice mejor con la presencia de alteraciones cognitivas que con variables clínicas o evolutivas. El clínico asistencial debería conocer si existe afectación o deterioro en las funciones neurocognitivas de sus pacientes pero en el medio asistencial cotidiano es difícil poder evaluar adecuadamente las funciones cognitivas y tampoco se acostumbra a cuantificar la funcion…

Inspiratory Muscle Training Among Frail Elderly People With Functional Impairment

2011

Dataset related to article "Development and external validation of a clinical prediction model for functional impairment after intracranial tumor sur…

2021

Anonymised clinical database containing information (Age, sex, prior surgery, tumor histology and maximum diameter, expected major brain vessel or cranial nerve manipulation, resection in eloquent areas and the posterior fossa, and surgical approach were recorded) about patients of Fondazione IRCCS Istituto Besta analysed for the article “Development and external validation of a clinical prediction model for functional impairment after intracranial tumor surgery”

Tenapanor for the treatment of irritable bowel syndrome with constipation.

2020

Introduction: Irritable bowel syndrome with constipation is associated with higher rates of functional impairment, as compared to other subtypes of the syndrome. Conventional laxative-based pharmacologic therapy of IBS-C, which is mostly symptom-based, is often unsatisfactory. Tenapanor represents a first-in-class orally available inhibitor of NHE3, which is minimally absorbed in the GI tract, what constitutes a significant therapeutic benefit, as it may act on the drug target. Areas covered: Aim of this article is to sum up the evidences about pharmacodynamics and pharmacokinetics of tenapanor, focusing on animal models and in vitro studies, but also discuss clinical trials on tenapanor's …