Search results for "Factor D"
showing 10 items of 48 documents
Complement activation and innate immunity
2007
Efficacy and safety of cyclic pyranopterin monophosphate substitution in severe molybdenum cofactor deficiency type A: a prospective cohort study.
2015
Summary Background Molybdenum cofactor deficiency (MoCD) is characterised by early, rapidly progressive postnatal encephalopathy and intractable seizures, leading to severe disability and early death. Previous treatment attempts have been unsuccessful. After a pioneering single treatment we now report the outcome of the complete first cohort of patients receiving substitution treatment with cyclic pyranopterin monophosphate (cPMP), a biosynthetic precursor of the cofactor. Methods In this observational prospective cohort study, newborn babies with clinical and biochemical evidence of MoCD were admitted to a compassionate-use programme at the request of their treating physicians. Intravenous…
Relationship and correspondence between different impact indicators in a sample of articles of excellence
2016
The objective was to compare the impact factor to 2 years of self-citations (IF2Y) with impact factor 2 years without self-citations (IF2YWS) and IF2Y with the impact factor to 5 years (IF5Y) as well as IF2YWS with SCImago Journal Rank (SJR) about journals where they were published articles of excellence in smoking by Spanish authors in the period 2008-2012. The search was conducted in the SCI-E and the SSCI-E on November 25, 2013. Were selected documents that had the h index of the strategy global sample (number of articles that have at least that number of citations) to search using the descriptors "smok ∗" OR "tobac ∗". A total of 69 articles by Spanish authors were recovered from 55 jou…
La responsabilidad Social Empresarial: un valor intangible y factor determinante de competitividad en las PYMES
2016
Robust dynamic comfort modeling for motorcycle riding
2015
Comfort modeling is considered a prerequisite in motorcycle design, primarily to address safety concerns and to position the product on the market. However, a comprehensive methodology for comfort modeling during the earliest development phases of a motorcycle model is still missing. Anthropometrical variation is the main noise factor to consider in comfort modeling in relation to the unavoidable variability of body segments. However, comfort is a subjective concept influencing riders' choice of motorcycle model. This work is a generalization of the robust ergonomic design methodology aimed at designing products whose ergonomic performance is insensitive to anthropometrical variation. This …
Robust dynamic comfort modelling for motorcycle riding
2015
Comfort modeling is considered a prerequisite in motorcycle design, primarily to address safety concerns and to position the product on themarket. However, a comprehensive methodology for comfort modeling during the earliest development phases of a motorcycle model is still missing. Anthropometrical variation is the main noise factor to consider in comfort modeling in relation to the unavoidable variability of body segments. However, comfort is a subjective concept influencing riders’ choice of motorcycle model. This work is a generalization of the robust ergonomic design methodology aimed at designing products whose ergonomic performance is insensitive to anthropometrical variation. This w…
Can we compare haemophilia carriers with clotting factor deficiency to male patients with mild haemophilia?
2020
Introduction Certain haemophilia carriers demonstrate an increased bleeding tendency, mainly related to clotting factor deficiency. No study has so far formally compared the bleeding phenotype of women and girls with mild FVIII or FIX deficiency and associated management with that of male patients affected by mild haemophilia A and B. Material and methods We retrospectively evaluated 44 women and girls with mild FVIII or FIX deficiency (FVIII or FIX 0.05-0.5 IU/mL) and 77 male patients with mild haemophilia A or B and compared them with respect to clotting factor level, age at and trigger for diagnosis, as well as treatment modalities. Results After excluding gender-related haemorrhagic sym…
What are the risk and protective factors for the well-being of adolescents with CF?
2021
La fibrosis quística (FQ) es una enfermedad crónica y hereditaria que compromete la vida de quienes la padecen, y se hace especialmente importante su impacto en la adolescencia. El afrontamiento que estos pacientes y sus familiares hagan de estas circunstancias que les han tocado vivir, puede mejorar o empeorar el curso y desenlace de la enfermedad. El objetivo es conocer los factores de riesgo y protectores que influyen en el bienestar de los adolescentes con FQ. Para ello se realizó una búsqueda bibliográfica de la literatura científica siguiendo la guía PRISMA en las siguientes bases de datos: Web of Science, ProQuest y Scopus. Se incluyeron artículos centrados en factores psicológicos d…
Blefaritis asociada al tratamiento con Cetuximab en adenocarcinoma colorrectal avanzado
2008
espanolCaso clinico: Mujer de 52 anos diagnosticada de adenocarcinoma colorrectal, remitida a nuestro servicio por presentar tras iniciar tratamiento con Cetuximab reaccion adversa palpebral. Discusion: El Cetuximab es un anticuerpo monoclonal cuya diana es el receptor del factor de crecimiento epidermico. Ha sido incorporado recientemente al tratamiento de tumores, principalmente el cancer colorrectal metastatico y los tumores del area otorrinolaringologica. Su tolerancia es en principio mejor que la de los agentes quimioterapicos clasicos. Sin embargo, no esta exento de efectos secundarios. La toxicidad palpebral asociada a Cetuximab ha sido recientemente descrita, por lo que la patogenia…
Literatura científica de autores españoles sobre análisis de citas y factor de impacto en Biomedicina (1981-2005)
2008
This paper analyses the development of Spanish research literature in the field of citation analysis and impact factor (IF) in biomedicine over the period 1981-2005. Bibliometric methods and social network analysis were used to examine papers indexed in the Science Citation Index-Expanded (SCI-Expanded), Social Sciences Citation Index (SSCI), MEDLINE, Índice Médico Español (IME) and Índice de Ciencias Sociales y Humanidades (ISOC) databases. 184 papers were identified, 79.89% of which were original research articles. Only four of these papers had been published before the 1990s. The mid 1990s saw a remarkable increase in the number of papers published (8-14 papers/year) with the highest pro…