Search results for "Factor V"

showing 6 items of 146 documents

Factor V Leiden, C>T MTHFR Polymorphism and Genetic Susceptibility to Preeclampsia

1997

SummaryWe performed a case-controlled study to investigate whether the FV Leiden mutation and the C>T677 polymorphism of the 5,10 methylene tetrahydrofolate reductase (MTHFR) are associated with the occurrence of preeclampsia in 96 otherwise healthy preeclamptic women and 129 parous women as controls. FV Leiden carriers were 10 (10.5%) in cases and 3 (2.3%) in controls (OR: 4.9, 95% Cl: 1.3-18.3). MTHFR TT homozygotes were 28 (29.8%) in cases and 24 (18.6%) in the control group (OR: 1.8,95% Cl 1.0-3.5). No difference in any of the polymorphisms was found between proteinuric (n = 45) and non-proteinur-ic (n = 51) patients. Moreover, MTHFR polymorphism does not affect the association betwe…

medicine.medical_specialtybiologybusiness.industryFactor VCase-control studyHematologymedicine.diseasefemale genital diseases and pregnancy complicationsPreeclampsiaEndocrinologyPolymorphism (computer science)Internal medicineMethylenetetrahydrofolate reductaseGenotypeFactor V Leidenmedicinebiology.proteinGenetic predispositionbusinessThrombosis and Haemostasis
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Congenital Factor VII Deficiency

2007

medicine.medical_specialtybiologybusiness.industrymedicine.diseaseGastroenterologyThrombosisRecombinant factor VIIaInternal medicineImmunologymedicinebiology.proteinSubstitution therapybusinessInherited Coagulation DisordersFactor VII deficiency
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C0025 Venous thromboembolism and factor V Leiden: Enigma or paradox

2012

medicine.medical_specialtybusiness.industryInternal medicinemedicineFactor V LeidenCardiologyHematologymedicine.diseasebusinessVenous thromboembolismThrombosis Research
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Recombinant FVIII Products (Turoctocog Alfa and Turoctocog Alfa Pegol) Stable Up to 40°C

2021

Mariasanta Napolitano,1 Arne Agerlin Olsen,2 Anne Mette Nøhr,2 Hermann Eichler3 1Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo Reference Regional Center for Thrombosis and Hemostasis, Hematology Unit, Palermo, Italy; 2Novo Nordisk A/S, Biopharm Manufacturing Development, Gentofte, Denmark; 3Saarland University and Saarland University Hospital, Institute of Clinical Haemostaseology and Transfusion Medicine, Homburg (Saar), GermanyCorrespondence: Anne Mette NøhrBiopharm Manufacturing Development, Novo Nordisk A/S, Nybrovej 80, Gentofte 2820, DenmarkTel +45 3075 1619Email amnq@novonordisk.…

medicine.medical_specialtybusiness.industryturoctocog alfa pegolHematologyTuroctocog alfa030204 cardiovascular system & hematologyGastroenterologyJournal of Blood Medicine03 medical and health sciences0302 clinical medicinetemperature stabilityfactor VIII030220 oncology & carcinogenesisAmbient humidityInternal medicinehemic and lymphatic diseasesmedicinePotencyfactor VIII hemophilia A storage flexibility temperature stability turoctocog alfa turoctocog alfa pegolhemophilia Astorage flexibilityturoctocog alfabusinessHot and humidOriginal ResearchJournal of Blood Medicine
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Incidence and Management Of Venous Thrombosis In Acute Leukemia: A Multicenter Study

2013

Abstract Background Venous thrombosis (VT) frequently complicates the clinical course of cancer. Reported incidence of VT in many hematological neoplasms is up to 10%, a value comparable to that of solid tumors. Available data on the incidence and management of VT in Acute Leukemia (AL) are scanty and quite discordant. We have performed a multicenter retrospective study with the primary objective to evaluate the incidence of venous thrombotic complications in a population of patients with AL. Secondary objective was to evaluate the management of these complications in patients with AL. Materials and Methods Available clinical records of out and in-patients diagnosed with AL from January 200…

medicine.medical_specialtyeducation.field_of_studyAcute leukemiamedicine.drug_classbusiness.industryImmunologyAnticoagulantPopulationLow molecular weight heparinCell BiologyHematologymedicine.diseaseBiochemistryGastroenterologyThrombosisSurgeryPulmonary embolismVenous thrombosisInternal medicinemedicineFactor V LeidenbusinesseducationVenous Thromboembolism Acute Leukemia A Multicenter Study
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Genetic Factors as Promising Biomarkers of Sporadic Ascending Aortic Aneurysm

2014

Thoracic aorta shows various changes with advancing age and a progressive deterioration in structure and function. As a result, vascular remodeling (VR) and medial degeneration (MD) occur. VR and MD are typical entities of sporadic thoracic aortic aneurysm (TAA), actually considered a common and serious health risk and a pathology by unclear mechanisms. Increased activity of the coagulation system, inflammation, activation of extracellular matrix remodeling and endothelial dysfunction pathways have been recently evidenced to have a key role in its onset. Thus, polymorphisms of the coagulation system [fibrinogen (rs1800790); Factor II ( rs1799963); Factor V (rs6025); Factor VII (rs121964926)…

tPA ( rs2020918)ACE (rs1799752)]PAI-1 (rs1799768)TAFI (rs2146881)] inflammation [TLR4 (rs4986790)Factor V (rs6025)CCR5 (rs333)] extra-cellular matrix remodeling [MMP9 (rs3918242)vascular remodeling (VR) and medial degeneration (MD)sporadic thoracic aortic aneurysm (TAA)polymorphisms of the coagulation system [fibrinogen (rs1800790)MMP2 (rs243865)] endothelium dysfunction [eNOs (rs 1799983)Factor II ( rs1799963)Factor VII (rs121964926)
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