Search results for "Factor ii"

showing 4 items of 34 documents

The role of insulin-like growth factor II in the malignant transformation of rat liver oval cells

1997

Oval cells are small nonparenchymal epithelial cells that first appear in the periportal areas of the liver and thereafter invade the whole parenchyma when mice or rats are exposed to a variety of chemical carcinogens. In the present study we have analyzed the expression of insulin-like growth factor II (IGF II) in the recently established oval cell line OC/CDE 22 and its malignantly transformed counterpart (the M22 cells) and the biological consequences of the constitutive expression of IGF II in oval cells. OC/CDE 22 cells do not express the above-mentioned growth factor, whereas the M22 cells do and addition of a neutralizing anti-IGF II antibody to M22 cells resulted in an almost comple…

medicine.medical_specialtyLiver cytologymedicine.medical_treatmentBiologyCell LineMalignant transformationMiceLiver Neoplasms ExperimentalGrowth factor receptorInsulin-Like Growth Factor IINeutralization TestsInternal medicinemedicineAnimalsAutocrine signallingHepatologyGrowth factorEpithelial CellsOncogenesTransfectionMolecular biologyRatsCell Transformation NeoplasticEndocrinologyLiverCell cultureInsulin-like growth factor 2biology.proteinMitogensHepatology
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Insulin-like growth factors in chick embryo retina during development.

1996

Evidence exists supporting an important role for insulin-like growth factors (IGFs) during fetal growth. In the present report we performed studies to define whether developing chick retina contains IGFs and whether IGFs play a role in the growth of this tissue. We have shown that both IGF-I and IGF-II are present in chick embryo retina throughout development (7th-18th day). The highest values, when expressed as ng/g of tissue, were found in the youngest retinas studied (7th-9th day) and at 16th-18th day of development. During whole development the content of IGF-II was about two to three times higher than that ascertained for IGF-I. The tissue also contains cell-surface binding for IGFs. H…

medicine.medical_specialtyPhysiologymedicine.medical_treatmentCellular differentiationClinical BiochemistryChick EmbryoBiologyInsulin-Like Growth Factor ReceptorBiochemistryRetinaInsulin-likeCellular and Molecular NeuroscienceInsulin-like growth factorEndocrinologyInsulin-Like Growth Factor IIInternal medicineCulture TechniquesmedicineAnimalsInsulin-Like Growth Factor IReceptorRetinaAffinity labelingEmbryoCell DifferentiationDNAEndocrinologymedicine.anatomical_structureInsulin-like growth factor 2Culture Media Conditionedbiology.proteinCell DivisionRegulatory peptides
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Role of insulin-like growth factors in autocrine growth of human retinoblastoma Y79 cells.

1996

In this study, we have demonstrated that human retinoblastoma Y79 cells produce insulin-like growth factors (IGFs) type I and type II and release them into the medium. We have also ascertained, by means of competitive studies and cross-linking procedure, that Y79 cells contain the type-I IGF receptor (IGF-IR). Furthermore, surface-bound IGF-I is internalised by the receptor, then degraded to amino acids. Insulin, IGF-I and IGF-II caused down-regulation of IGF-IR; the effect is concentration and time dependant. Scatchard analysis demonstrated that incubation with insulin markedly decreased the binding capacity measured for IGF-I while the apparent Kd value calculated for IGF-I binding was no…

medicine.medical_specialtymedicine.medical_treatmentBiologyBiochemistryBinding CompetitiveReceptor IGF Type 1chemistry.chemical_compoundInsulin-Like Growth Factor IIInternal medicineInsulin receptor substratemedicineHumansInsulinInsulin-Like Growth Factor IAutocrine signallingPhosphotyrosineInsulin-like growth factor 1 receptorInsulinRetinoblastomaTyrosine phosphorylationPhosphoproteinsIRS2Insulin receptorautocrine growthEndocrinologychemistrybiology.proteinInsulin Receptor Substrate ProteinsPlatelet-derived growth factor receptorCell DivisionSignal TransductionEuropean journal of biochemistry
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Genetic Factors as Promising Biomarkers of Sporadic Ascending Aortic Aneurysm

2014

Thoracic aorta shows various changes with advancing age and a progressive deterioration in structure and function. As a result, vascular remodeling (VR) and medial degeneration (MD) occur. VR and MD are typical entities of sporadic thoracic aortic aneurysm (TAA), actually considered a common and serious health risk and a pathology by unclear mechanisms. Increased activity of the coagulation system, inflammation, activation of extracellular matrix remodeling and endothelial dysfunction pathways have been recently evidenced to have a key role in its onset. Thus, polymorphisms of the coagulation system [fibrinogen (rs1800790); Factor II ( rs1799963); Factor V (rs6025); Factor VII (rs121964926)…

tPA ( rs2020918)ACE (rs1799752)]PAI-1 (rs1799768)TAFI (rs2146881)] inflammation [TLR4 (rs4986790)Factor V (rs6025)CCR5 (rs333)] extra-cellular matrix remodeling [MMP9 (rs3918242)vascular remodeling (VR) and medial degeneration (MD)sporadic thoracic aortic aneurysm (TAA)polymorphisms of the coagulation system [fibrinogen (rs1800790)MMP2 (rs243865)] endothelium dysfunction [eNOs (rs 1799983)Factor II ( rs1799963)Factor VII (rs121964926)
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