Search results for "Factories"
showing 9 items of 9 documents
Iwr1 facilitates RNA polymerase II dynamics during transcription elongation.
2017
Iwr1 is an RNA polymerase II (RNPII) interacting protein that directs nuclear import of the enzyme which has been previously assembled in the cytoplasm. Here we present genetic and molecular evidence that links Iwr1 with transcription. Our results indicate that Iwr1 interacts with RNPII during elongation and is involved in the disassembly of the enzyme from chromatin. This function is especially important in resolving problems posed by damage-arrested RNPII, as shown by the sensitivity of iwr1 mutants to genotoxic drugs and the Iwr1's genetic interactions with RNPII degradation pathway mutants. Moreover, absence of Iwr1 causes genome instability that is enhanced by defects in the DNA repair…
Olleros, alfareros y fabricantes de loza en Ribesalbes, entre 1742 y 1817
2012
El desarrollo de la tradición alfarera en Ribesalbes, y el posterior establecimiento de las primeras fábricas de loza, a finales del siglo XVIII, viene determinado por los condicionantes naturales e históricos de la villa; así como por la influencia decisiva de la Real Manufactura del conde de Aranda, en la vecina población de L’Alcora. En este trabajo, a partir de diversas fuentes documentales primarias, entre las que cabe destacar los libros sacramentales del Archivo Parroquial de Ribesalbes, y la Contribución general de 1817, se constata la presencia de olleros en la Baronía, a principios del siglo XVIII. Se determinan también los nombres de algunos alfareros, registrados en los albores …
Tommaso Maria Napoli Utriusque Architecturae Compendium Roma 1688 Breve trattato sulle fabbriche civili e militari e la conservazione delle architett…
2013
Il volume Tommaso Maria Napoli Utriusque Architecturae Compendium Roma 1688 Breve trattato sulle fabbriche civili e militari e la conservazione delle architetture del frate domenicano Tommaso Maria Napoli, vuole contribuire ad accrescere le nostre conoscenze sui principi che dovevano sottendere alla realizzazione dell’architettura civile e militare del periodo barocco e tardo barocco, così come espressi nel breve trattato scritto dal frate architetto, nato a Palermo, Tommaso Maria Napoli (1659-1725), e pubblicato a Roma alla fine del Seicento. Alla traduzione dal latino del trattato, redatta da esperti (Fabio Zarbo e Pietro Zarbo), è inclusa un’interessante ricerca, redatta congiuntamente c…
Chromatin-dependent regulation of RNA polymerases II and III activity throughout the transcription cycle
2015
The particular behaviour of eukaryotic RNA polymerases along different gene regions and amongst distinct gene functional groups is not totally understood. To cast light onto the alternative active or backtracking states of RNA polymerase II, we have quantitatively mapped active RNA polymerases at a high resolution following a new biotin-based genomic run-on (BioGRO) technique. Compared with conventional profiling with chromatin immunoprecipitation, the analysis of the BioGRO profiles in Saccharomyces cerevisiae shows that RNA polymerase II has unique activity profiles at both gene ends, which are highly dependent on positioned nucleosomes. This is the first demonstration of the in vivo infl…
A complete set of nascent transcription rates for yeast genes
2010
The amount of mRNA in a cell is the result of two opposite reactions: transcription and mRNA degradation. These reactions are governed by kinetics laws, and the most regulated step for many genes is the transcription rate. The transcription rate, which is assumed to be exercised mainly at the RNA polymerase recruitment level, can be calculated using the RNA polymerase densities determined either by run-on or immunoprecipitation using specific antibodies. The yeast Saccharomyces cerevisiae is the ideal model organism to generate a complete set of nascent transcription rates that will prove useful for many gene regulation studies. By combining genomic data from both the GRO (Genomic Run-on) a…
Genome-wide studies of mRNA synthesis and degradation in eukaryotes
2012
In recent years, the use of genome-wide technologies has revolutionized the study of eukaryotic transcription producing results for thousands of genes at every step of mRNA life. The statistical analyses of the results for a single condition, different conditions, different transcription stages, or even between different techniques, is outlining a totally new landscape of the eukaryotic transcription process. Although most studies have been conducted in the yeast Saccharomyces cerevisiae as a model cell, others have also focused on higher eukaryotes, which can also be comparatively analyzed. The picture which emerges is that transcription is a more variable process than initially suspected,…
Zheng Xiaoqiong's Poetry and Chinese Factories: a Mirror of Uneven Development
2017
L'opera poetica della poetessa Zheng Xiaoqiong è presentata in relazione al contesto delle fabbriche da cui nasce. The poetry of Zheng Xiaoqiong, a woman poet, is presented on the background of the factories that are the place where it developed from.
Sovellusaluemallinnus ohjelmistotuotannon tukena
2006
Tar ekun fabrika
1933
Apskats par rūpniecību sociālisma un kapitālisma sistēmā. Tulkojums no krievu valodas evenku valodā.