Search results for "Farm"
showing 10 items of 3554 documents
Ferulskābes noteikšana Centaurium Erythraea, izmantojot šķidrumu hromatogrāfijas-masspektrometrijas metodi
2015
Maģistra darba mērķis bija veikt čemura augstiņa (Centaurium erythraea) ķīmiskā sastāva un bioloģiskās aktivitātes izvērtēšanu. Analizēti tika in vitro augu, in vitro augu audu, kallusa kultūru un drogas paraugi. Rezultātā tika atrasti divi savienojumi-izoferulskābe (izo-FS) un dihidroferulskābe (dihidro-FS). Veicot ķīmisko izvērtējumu, secināts, ka izo-FS labāk šķīst 96% etanolā, bet dihidro-FS-0% etanolā; abi savienojumi no visām kultūrām lielākā daudzumā atrodami in vitro augu kultūrā. Čemura augstiņa kopējais fenolu daudzums un antiradikālā aktivitāte vislielākā ir in vitro audu augu kultūrā.
Nuovi inibitori di Aurora chinasi A come target biologico coinvolto nei processi carcinogenici
2011
Identificando Aurora chinasi A come target elettivo per l’inibizione dell’espansione tumorale è stato sfruttato l’approccio computazionale per effettuare un virtual screening su una libreria “in house” di strutture molecolari. L’analisi dei dati computazionali ha permesso di identificare nei derivati della serie pirido[3’,2’:4,5]furo[3,2-d]-1,2,3-triazin-4(3H)one di tipo 3 nuovi composti a potenziale attività inibitoria sul sito ATP-asico di Aurora chinasi A. La sintesi del sistema triciclico-eteroaromatico 3 prevede la diazotazione della 3-amino-furopiridina 1 e conseguente reazione di copulazione con una serie di ammine primarie opportunamente scelte, permettendo l’isolamento delle 3-tria…
La Ley 41/2002, de 14 de noviembre, básica reguladora de la autonomia del paciente y de los derechos y obligaciones en materia de información y docum…
2003
En el presente trabajo se va a exponer (por su extensión en dos partes) el contenido básico de la reciente Ley sobre autonomía de los pacientes, con referencia expresa a las leyes autonómicas sobre la misma materia. Es de destacar que en todas ellas se consagra como un principio fundamental en la relación médico-paciente el principio de información y requerimiento del consentimiento al paciente para la realización de cualquier intervención sobre el mismo. Asimismo, se establecen los mecanismos de sustituciónde ese consentimiento cuando el paciente no se encuentre en condiciones de darlo por incapacidad o minoría de edad. Por otra parte, se regula mínimamente el documento de voluntades antic…
Folate-targeted supramolecular vesicular aggregates based on polyaspartyl-hydrazide copolymers for the selective delivery of antitumoral drugs.
2010
Supramolecular vesicular aggregates (SVAs) have the advantage of combining the safe and biocompatible properties of colloidal vesicular carriers based on phospholipids with those of polymeric materials, i.e. polyaspartyl-hydrazide (PAHy) copolymers. To provide SVAs with a certain tumour selectivity, folate moieties were chemically conjugated to PAHy copolymers. Physicochemical properties (mean sizes, polydispersity index and zeta potential) of folate-targeted SVAs (FT-SVAs) loaded with gemcitabine were evaluated. The antiproliferative and anticancer activity of gemcitabine-loaded FT-SVAs was evaluated against two cancer cell lines, i.e. MCF-7 cells which over-express the folate receptor and…
Evaluación etnobotanica de la Yareta (Azorella compacta) en Arequipa (Perú) y sus posibles aplicaciones
2013
Abstract – Ethnobotanical study of the Yareta Arequipa plant (Azorella compacta Phil) and its possible applications. – The aim of this work is the ethnobotanical characterisation of the Yareta Arequipa plant (Azorella compacta Phil), to report indications about the uses of the Yareata plant by “Salinas y Aguada Blanca” National Reserve (RNSAB) populations and to find its possible applications. The survey has been lead on nine communities of the Arequipa Region (Peru), it concerned the actual degree of conservation of the plants, the botanical description and classification, the ecological characterization, the use and the distribution in ethnomedicine and ethnopharmacology and all the uses …
Synthesis and in vitro antimicrobial activities of new (cyano-NNO-azoxy) pyrazole derivatives
2011
The antibacterial and antifungal activity of a series of products, in which the 1,5-dimethyl-4-(cyano- NNO-azoxy)pyrazol-3-yl and 1,3-dimethyl-4-(cyano-NNO-azoxy)pyrazol-5-yl moieties were linked to pyridine, pyrazole, isoxazole, thiophene and the furan ring, were examined. No molecule displayed activity against the Gram-negative bacteria tested. Conversely, some compounds displayed activity against two Staphylococcus aureus strains, including the methicillin resistant strain. All compounds displayed interesting antifungal activity, the most active compound of the series being the thiophene derivative 7a. This compound’s activity against Candida krusei and Candida glabrata (MIC = 0.25 and 0…
STATISTICAL ANALYSIS OF A SURVEY ABOUT DIFFUSION OF BINGE DRINKING AND DRUNKOREXIA AMONG YOUNG PEOPLE
2017
Youth alcohol consumption is a major global public health concern. Previous reviews have concluded that exposure to alcohol marketing was associated with drinking initiation and higher alcohol consumption among youth. From January to May 2017, a survey has been conducted through administration of questionnaires about the diffusion of binge drinking and drunkorexia among the students of Palermo. Test was administered, during school time, to 2331 students between the ages of 13 and 20. Regarding the analysis of the questionnaires, 97.8% of student declare to have drunk at least once: their first taste of alcoholic drink happens at the age of thirteen/fourteen. They prefer to drink at the disc…
Epilepsijas ārstēšana, medikamentu aprite un to ietekme uz koncentrēšanās spējām Bērnu klīniskajā universitātes slimnīcā
2017
Ievads: Latvijā netiek veidots reģistrs, kurā atspoguļotos epilepsijas ārstēšanas specifika 0 – 18 gadu vecuma grupā. Mērķis: noskaidrot epilepsijas ārstēšanas specifiku, pielietotās diagnostikas metodes, hospitalizēto, pirmreizēji diagnosticēto, medikamentozo terapiju uzsākušo pacientu skaitu; veikt zāļu apriti 2014. - 2016.gadam Bērnu Klīniskās Universitātes slimnīcas (BKUS) pacientiem vecuma grupā no 0 līdz 18 gadiem. Metode: BKUS arhīvā pieejamo bērnu slimības karšu analīze, intervija ar BKUS neirologu un pilotpētījums, izvēloties “Vizuālā mājiena meklēšanas”, “Perceptuālās saskaņošanas”, “Šternberga skenēšanas” testus. Rezultāti: 2014. – 2016. gadam BKUS saistībā ar epileptisku lēkmi h…
The Agr communication system provides a benefit to the populations of Listeria monocytogenes in soil
2014
International audience; In this study, we investigated whether the Agr communication system of the pathogenic bacterium Listeria monocytogenes was involved in adaptation and competitiveness in soil. Alteration of the ability to communicate, either by deletion of the gene coding the response regulator AgrA (response-negative mutant) or the signal pro-peptide AgrD (signal-negative mutant), did not affect population dynamics in soil that had been sterilized but survival was altered in biotic soil suggesting that the Agr system of L. monocytogenes was involved to face the complex soil biotic environment. This was confirmed by a set of co-incubation experiments. The fitness of the response-negat…
Asymmetric Michael Addition in Synthesis of β-Substituted GABA Derivatives
2022
γ-Aminobutyric acid (GABA) represents one of the most prolific structural units widely used in the design of modern pharmaceuticals. For example, β-substituted GABA derivatives are found in numerous neurological drugs, such as baclofen, phenibut, tolibut, pregabalin, phenylpiracetam, brivaracetam, and rolipram, to mention just a few. In this review, we critically discuss the literature data reported on the preparation of substituted GABA derivatives using the Michael addition reaction as a key synthetic transformation. Special attention is paid to asymmetric methods featuring synthetically useful stereochemical outcomes and operational simplicity. This research was funded by the National Na…