Search results for "Farmaceutica"
showing 10 items of 582 documents
Phytol and Heptacosane Are Possible Tools to Overcome Multidrug Resistance in an In Vitro Model of Acute Myeloid Leukemia
2022
Drug resistance is the ability of cancer cells to gain resistance to both conventional and novel chemotherapy agents, and remains a major problem in cancer therapy. Resistance mechanisms are multifactorial and involve more strictly pharmacological factors, such as P-glycoprotein (P-gp) and biological factors such as inhibitor of apoptosis proteins (IAPs) and the nuclear factor-kappa B (NF-κB) pathway. Possible therapeutic strategies for the treatment of acute myeloid leukemia (AML) have increased in recent years; however, drug resistance remains a problem for most pa-tients. Phytol and heptacosane are the major compounds of Euphorbia intisy essential oil (EO) which were demonstrated to inhi…
Sintesi e studi SAR di nuovi derivati 4-NO- e (4-ONNCN)-pirazolici
2011
Invasive alien species – potential cheap resources of plant substances for medicinal use
2018
Some alien species demonstrate rather invasive behaviour. They have high tolerance of various habitat conditions and potent propagation ability. They not only over-compete the local vegetation but suppress the seed development of the native plants. In the newly invaded habitats they might not have suitable herbivores to control their populations. The only effective enemy might be Homo sapiens. Humans are known with their destructive power once an object has become significant for industrial utilization. The aim of this study is to review research data and reveal the potential of Ambrosia artemisiifolia L., Erigeron canadensis L., Xanthium strumarium L. and Dittrichia graveolens (L.) W. Greu…
New indole and 7-azaindole derivatives as protein kinase inhibitors
2023
Role of hypoxia in pemetrexed-resistance of mesothelioma mediated by proton-coupled folate transporter, and preclinical activity of new anti-LDH comp…
2018
Introduction There are few effective therapies for malignant pleural mesothelioma (MPM), which remains one of the most lethal cancers. We previously demonstrated that low expression of the PCFT transporter, both at mRNA and protein levels, is associated with shorter survival of MPM patients treated with pemetrexed (Giovannetti et al., 2017). Since hypoxia has also been associated to antifolate-resistance (Raz et al, 2014), this study was aimed at elucidating key factors in pemetrexed resistance and hypoxia that may contribute to the rational development of novel therapeutic interventions against mesothelioma. Methods The levels of PCFT and of the hypoxia marker carbonic anhydrase-IX were de…
Apoptotic induction on HeLa tumor cell line. A comparison of activity between pyrazolo[1,2-a]benzo[1,2,3,4]tetrazinone derivatives and their syntheti…
2009
Fighting Antibiotic Resistance: New Pyrimidine-Clubbed Benzimidazole Derivatives as Potential DHFR Inhibitors
2023
The present work describes the design and development of seventeen pyrimidine-clubbed benzimidazole derivatives as potential dihydrofolate reductase (DHFR) inhibitors. These compounds were filtered by using ADMET, drug-likeness characteristics calculations, and molecular docking experiments. Compounds 27, 29, 30, 33, 37, 38, and 41 were chosen for the synthesis based on the results of the in silico screening. Each of the synthesized compounds was tested for its in vitro antibacterial and antifungal activities using a variety of strains. All the compounds showed antibacterial properties against Gram-positive bacteria (Staphylococcus aureus and Staphylococcus pyogenes) as well as Gram-negativ…