Search results for "Farnesol"

showing 4 items of 4 documents

Efficiency of Target Larvicides Is Conditioned by ABC-Mediated Transport in the Zoonotic Nematode Anisakis pegreffii

2018

Anisakiasis is among the most significant emerging foodborne parasitoses contracted through consumption of thermally unprocessed seafood harboring infective Anisakis species larvae. The efficacy of the currently applied anthelminthic therapy in humans and in model organisms has not proven sufficient, so alternative solutions employing natural compounds combined with chemical inhibitors should be explored. By testing toxicity of the natural monoterpenes nerolidol and farnesol and the conventional anthelminthics abamectin and levamisole in the presence/absence of MK-571 and Valspodar, which inhibit the ABC transporter proteins multidrug resistance protein (MRP-like) and P-glycoprotein (P-gp),…

0301 basic medicineNematodaAnisakis antiparasitic agents multidrug resistance proteinsAnisakiATP-binding cassette transporterAnisakiasisAnisakisMicrobiology03 medical and health scienceschemistry.chemical_compound0302 clinical medicineMechanisms of ResistanceTubulinSettore AGR/20 - ZoocoltureAnimalsHumansPharmacology (medical)ATP Binding Cassette Transporter Subfamily B Member 1Settore BIO/06 - Anatomia Comparata E CitologiaNerolidolPharmacologybiologyAntiparasitic AgentsTransporterFarnesolbiology.organism_classificationAnisakis030104 developmental biologyInfectious DiseasesNematodechemistryLevamisole030220 oncology & carcinogenesisLarvaAbamectinATP-Binding Cassette TransportersEffluxABC transporterSesquiterpenes
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The chemical composition of the aerial parts essential oil of Lonas annua (L.) Vines & Druce (Asteraceae)

2022

Lonas annua (L.) Vines & Druce (Asteraceae), commonly known as African Daisy or Yellow Ageratum is a rare therophyte native to northwestern Africa (Algeria, Morocco, and Tunisia) and Italy (Sicily and Sardinia). In the present study, the chemical composition of the essential oil from aerial parts of Lonas annua was analyzed by GC-MS. No one report has been previously published on the essential oil of this species. The results showed the presence of large quantity of two unusual metabolites 2,3-dihydrofarnesol (41.64%), and acenaphthene (36.18%). Chemotaxonomic considerations were carried out in order to confirm the phylogenetic reconstructions of Anthemideae.

3-dihydrofarnesolchemotaxonomyAfrican Daisycompositaevolatile compositionOrganic Chemistry2Plant ScienceBiochemistrysicilian floraacenaphtheneAnalytical ChemistryNatural Product Research
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Enhanced steatosis by nuclear receptor ligands: a study in cultured human hepatocytes and hepatoma cells with a characterized nuclear receptor expres…

2010

Steatosis is the first step in the development of non-alcoholic fatty liver disease (NAFLD). However, the mechanisms involved in its pathogenesis are not fully understood. Many nuclear receptors (NRs) involved in energy homeostasis and biotransformation constitute a network connecting fatty acids, cholesterol and xenobiotic metabolisms; therefore, multiple NRs and their ligands may play a prominent role in liver fat metabolism and accumulation. In this study we have attempted to gain insight into the relevance of the NR superfamily in NAFLD by investigating the steatogenic potential of 76 different NR ligands in fatty acid overloaded human hepatocytes and hepatoma cells. Moreover, we have d…

Selective Estrogen Receptor ModulatorsIndolesPeroxisome proliferator-activated receptorReceptors Cytoplasmic and NuclearBiologyRetinoid X receptorPhloroglucinolToxicologyLigandsCalcitriol receptorBridged Bicyclo CompoundsPregnenedionesmedicineHumansLiver X receptorVitamin ACells CulturedCalcifediolchemistry.chemical_classificationPregnane X receptorAndrostenolsTerpenesFatty liverFatty acidGeneral MedicineHep G2 Cellsmedicine.diseaseFarnesolFatty LiverPPAR gammaTamoxifenCholesterolNuclear receptorchemistryBiochemistryHepatocytesChemico-biological interactions
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Terpenoid Constituents ofZanthoxylum acanthopodiumDC. Leaves

2008

Abstract The chemical composition of the essential oil of Zanthoxylum acanthopodium DC. leaves was analyzed by GC and GC/MS. Fifty-eight compounds accounting for 75.6% of the oil were identified. The major compounds were linalool (14.3%), 9,12-octadecadien-ol (8.4%), 1,8-cineole (7.7%), 2-undecanone (7.3%), farnesol (3.6%), 9,12,15-octadecatrien-1-ol (3.2%) and β-caryophyllene (3.0%).

biologyGeneral ChemistryFarnesolbiology.organism_classificationTerpenoidlaw.inventionchemistry.chemical_compoundRutaceaeLinaloolchemistryZanthoxylumlawBotanyChemical compositionEssential oilJournal of Essential Oil Research
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