Search results for "Fas"

Role Of S-Nitrosylation In The Extrinsic Apoptotic Signalling Pathway In Cancer.

2015

One of the key features of tumour cells is the acquisition of resistance to apoptosis. Thus, determining therapeutic strategies that circumvent apoptotic resistance and result in tumor regression is a challenge. One strategy to induce apoptosis is to activate death receptor signalling pathways. Members of the Tumor Necrosis Factor TNF-family death receptors ligand (TRAIL, FasL and TNF-α) can originate from immune and non-immune cells. Death receptors, engaged by cognate ligands, can initiate multiple signaling pathways, which can generate diverse outcomes, including non-apoptosis-related signal. Knowledge on the molecular mechanisms (that determine death or survival of tumour cells) followi…

El último intelectual (y 4). Un modelo

2007

NF-κB Inhibition Restores Sensitivity to Fas-Mediated Apoptosis in Lymphoma Cell Lines

2003

Failure to perform the Fas-related apoptosis pathway can account for tumor resistance both to chemotherapeutic agents and to immunological effectors. We studied the role of NK-kappaB in Fas-resistance, employing the Fas-sensitive human T-lymphoma HuT78 cell line and its Fas-resistant variants HuT78B1 and HuT78G9. All these cell lines expressed high levels of constitutively activated NF-kappaB. Pretreatment of cells with NF-kappaB inhibitors (PDTC, MG132, or SN50) strongly enhanced CH11-induced apoptosis in HuT78 and Hut78G9 cells, while only MG132 showed a similar potentiating effect in HuT78B1. The described synergism was significantly inhibited by pretreatment with the anti-Fas-blocking a…

Apoptosis in liver disease

2001

A variety of biological functions are regulated through extracellular signals. Amongst the best studied examples is growth control, which is achieved by the regulatory function of growth factors. In recent years it has become apparent that cell death (apoptosis) is controlled in a similar fashion. Apoptosis, firstly a morphologically defined process, is a highly controlled type of cell death that plays a critical role in embryonic development, deletion of autoreactive T-cells and adult tissue homoeostasis. There is increasing evidence that derangement of the apoptotic program is the underlying cause of a series of diseases including liver diseases. The deadly program can be initiated by lig…

Fast Photochemistry of Prototypical Phytochromes—A Species vs. Subunit Specific Comparison

2015

Phytochromes are multi-domain red light photosensor proteins, which convert red light photons to biological activity utilizing the multitude of structural and chemical reactions. The steady increase in structural information obtained from various bacteriophytochromes has increased understanding about the functional mechanism of the photochemical processes of the phytochromes. Furthermore, a number of spectroscopic studies have revealed kinetic information about the light-induced reactions. The spectroscopic changes are, however, challenging to connect with the structural changes of the chromophore and the protein environment, as the excited state properties of the chromophores are very sens…

Identification of enolase as a plasminogen-binding protein in excretory-secretory products ofFasciola hepatica

2004

AbstractWe have followed a combined proteomic approach to identify proteins of Fasciola hepatica that could be involved in host–parasite interactions. Using two-dimensional gel electrophoresis, far Western immunoblot and mass spectrometry analyses, we have identified the enolase enzyme, present in the excretory/secretory materials of F. hepatica, as a human plasminogen-binding protein. This enzyme has an apparent molecular weight of 47 kDa with pI ranging from 6.2 to 7.2. These results suggest that enolase could act as a plasminogen receptor.

Extracellular vesicles from parasitic helminths contain specific excretory/secretory proteins and are internalized in intestinal host cells.

2012

The study of host-parasite interactions has increased considerably in the last decades, with many studies focusing on the identification of parasite molecules (i.e. surface or excretory/secretory proteins (ESP)) as potential targets for new specific treatments and/or diagnostic tools. In parallel, in the last few years there have been significant advances in the field of extracellular vesicles research. Among these vesicles, exosomes of endocytic origin, with a characteristic size ranging from 30-100 nm, carry several atypical secreted proteins in different organisms, including parasitic protozoa. Here, we present experimental evidence for the existence of exosome-like vesicles in parasitic…

L'incursione della "prova negoziata" nel giudizio penale (alcuni rilievi critici)

2003

L'Autrice si sofferma sulle modifiche introdotte dalla c.d. legge Carotti nella disciplina del fascicolo per il dibattimento. In particolare l'attenzione è concentrata sul nuovo comma 2 dell'art. 431 c.p.p., nel quale è prevista la facoltà per le parti di concordare l'acquisizione al fascicolo per il dibattimento di atti contenuti nel fascicolo del pubblico ministero, nonché della documentazione relativa all'attività di investigazione difensiva, facoltà esercitabile anche in sede di formulazione delle richieste probatorie ai sensi dell'art. 493, comma 3, c.p.p. Si verifica l'impatto della nuova disciplina sul principio di oralità-immediatezza, sul quale l'assunzione delle prove nel contradd…

Una Nueva Técnica de Remodelación de la Punta Nasal en Rinoplastia, para Casos Extremadamente Difíciles, Mediante la Resección Total de los Cartílago…

2015

Leonardo Da Vinci solía decir que: “La nariz está ahí para manifestar el carácter del rostro”. Y ya en el s. XX, Jack Sheen afirmó con rotundidad: “La Rinoplastia es una operación tremendamente difícil aunque técnicamente resulte decepcionantemente fácil”. La Rinoplastia es una de las operaciones más frecuentes en Cirugía Plástica, es la más difícil, creativa, artística, estudiada, debatida, controvertida, apasionante y siempre fascinante. Y la parte más difícil de abordar con éxito en una rinoplastia es la Punta. Presentamos una Nueva Técnica de Remodelación de la Punta Nasal en Rinoplastia, para Casos Extremadamente Difíciles, Mediante la Resección Total de los Cartílagos Alares y Fascia …

Biorthogonal Wavelet Transforms Originating from Discrete and Discrete-Time Splines

2018

This chapter describes how to generate families of biorthogonal wavelet transforms in spaces of periodic signals using prediction p-filters originating from discrete-time and discrete splines. The transforms are generated by the lifting scheme (Sweldens (Wavelet applications in signal and image processing III, vol 2569, 1995, [7]), Sweldens (Appl Comput Harmon Anal 3:186–200, 1996, [8]), Sweldens (SIAM J Math Anal 29:511–546, 1997, [9]), see also Sect. 7.1 of this volume). The discrete-time wavelets related to those transforms are (anti)symmetric, well localized in time domain and have flat spectra. These families comprise wavelets with any number of local discrete vanishing moments (LDVMs)…