Search results for "FasL"
showing 4 items of 4 documents
Aging and systemic hormonal status affects the circulating miR-21, miR-146a and FasL levels
2015
MicroRNAs are small molecules, found in all cell types and body fluids, which most commonly affect negatively to gene expressions by translational repression. Their role in various physiological conditions and diseases has been emphasized during the last twenty years. In our recent studies with postmenopausal monozygotic twin sisters (n=11), we have investigated how different systemic hormonal status affects the levels of specific circulating microRNAs and other molecules related to inflammation and apoptosis, both processes associated with aging. Our results have shown that the systemic levels of miR-21, miR-146a and Fas ligand are lower within the postmenopausal women who are using estrog…
Verenkierron MMP-entsyymien ja Fas-ligandin yhteydet eri-ikäisten naisten kehonkoostumukseen ja hormonaaliseen tilaan
2016
Ikääntyvillä ihmisillä kehon koostumuksen muuttuminen yhdessä lihaksiston heikentymisen kanssa on merkittävä toimintakykyyn ja elämänlaatuun vaikuttava tekijä. Ikääntyessä yleisesti vaikeutunut liikkuminen, korkeampi kaatumisen riski sekä metaboliseen oireyhtymään ja/tai tyypin II diabetekseen sairastuminen voivat olla seurauksia heikentyneestä toimintakyvystä. Naisilla vaihdevuosien aikana estrogeenin tuotanto vähenee huomattavasti, ja estrogeenin vähenemisen on havaittu olevan yhteydessä rasvakudoksen määrän lisääntymiseen, lihasten koon pienenemiseen ja lihasvoiman heikkenemiseen. Vaihdevuosien oireita hoidetaan mm. estrogeenia sisältävällä hormonikorvaushoidolla, mutta estrogeenin vaiku…
Research of prognostic biomarkers in Tunisian patients with bladder cancer
2016
Bladder cancer is the first most common urogenital cancer in men in Tunisia, with a high recurrence rate. Patients with muscle-invasive disease develop metastasis. The need for expensive continuous surveillance. In this thesis we try to search some candidate biomarkers. Their use for cancer staging and personalization of therapy at the time of diagnosis in order to identify a better treatment could improve patient care. The aim of this first part of our study was to investigate the clinical significance of three immune cell-related transcription factors, T-bet, GATA-3 and Bcl-6 in Tunisian patients with bladder cancer. We found that T-bet level was significantly higher in invasive carcinoma…
NF-κB Inhibition Restores Sensitivity to Fas-Mediated Apoptosis in Lymphoma Cell Lines
2003
Failure to perform the Fas-related apoptosis pathway can account for tumor resistance both to chemotherapeutic agents and to immunological effectors. We studied the role of NK-kappaB in Fas-resistance, employing the Fas-sensitive human T-lymphoma HuT78 cell line and its Fas-resistant variants HuT78B1 and HuT78G9. All these cell lines expressed high levels of constitutively activated NF-kappaB. Pretreatment of cells with NF-kappaB inhibitors (PDTC, MG132, or SN50) strongly enhanced CH11-induced apoptosis in HuT78 and Hut78G9 cells, while only MG132 showed a similar potentiating effect in HuT78B1. The described synergism was significantly inhibited by pretreatment with the anti-Fas-blocking a…