Search results for "Female infertility"
showing 8 items of 18 documents
Obesity and assisted reproductive technology outcomes.
2006
Obesity is a rising health problem in Western societies. It has been related to increased morbidity and mortality rates due to several pathologies. In the field of gynaecology and reproduction, obesity is associated with menstrual disorders, hirsutism, infertility, miscarriage and obstetric complications. It is known to impair human reproduction through different mechanisms such as insulin resistance, hyperandrogenism and elevated leptin levels. Weight management and dietary intervention can reverse this situation and improve reproductive function. Obesity can also impair the outcome of assisted reproductive technologies. The lower probability of a healthy live birth described in obese wome…
Reproductive System Outcome Among Patients with Polycystic Ovarian Syndrome.
2015
Polycystic ovarian syndrome (PCOS) may present with different clinical patterns and the anovulatory phenotype may not be the most common. Data suggest that anovulation in PCOS is not the consequence of increased androgen ovarian secretion but rather of a severe derangement of early follicle development. Other mechanisms may be operative in subgroups of patients and may contribute to the arrest of follicle growth and anovulation. At least 50% of anovulatory patients with PCOS become ovulatory in their late reproductive age. There is also evidence that menopause may occur later in women with PCOS. Finally, a strategy for treatment of infertility in PCOS is presented.
Ovarian stimulation for ovulation induction and in vitro fertilization in patients with systemic lupus erythematosus and antiphospholipid syndrome.
2008
Objective To review the current evidence regarding the relationship between systemic lupus erythematosus (SLE) and antiphospholipid syndrome and female infertility, as well as the risks associated with ovarian stimulation for ovulation induction and IVF. To establish, based on this information, guidelines for safe and successful assisted reproductive technology (ART). Design A MEDLINE computer search was performed to identify relevant articles. Result(s) Systemic lupus erythematosus and antiphospholipid syndrome are not related to infertility, except for cases of amenorrhea accompanying severe flares, renal insufficiency-related hypofertility, and ovarian failure secondary to cyclophosphami…
INFLAMMATORY BOWEL DISEASE AND INFGERTILITY: ANALYSIS OF LITERATURE AND FUTURE PERSPECTIVES
2021
Background: inflammatory bowel diseases (IBD) are chronic disorders that affect the gastrointestinal tract but which also present extraintestinal manifestations. One of the problems related to IBD is the presence of bothfemale and male infertility. Aim: determine the correlation between IBD and male and female infertility by analyzing the literature. Material and method: studies carried out in the last twenty years have been selected through the PubMed search engine. Only studies were selected that in their conclusions showed a real correlation between IBD and infertility. Results: the first cause of infetility in both sexes is related to the surgical interventions that patients have to fac…
Loss-of-function maternal-effect mutations of PADI6 are associated with familial and sporadic Beckwith-Wiedemann syndrome with multi-locus imprinting…
2020
Abstract Background PADI6 is a component of the subcortical maternal complex, a group of proteins that is abundantly expressed in the oocyte cytoplasm, but is required for the correct development of early embryo. Maternal-effect variants of the subcortical maternal complex proteins are associated with heterogeneous diseases, including female infertility, hydatidiform mole, and imprinting disorders with multi-locus imprinting disturbance. While the involvement of PADI6 in infertility is well demonstrated, its role in imprinting disorders is less well established. Results We have identified by whole-exome sequencing analysis four cases of Beckwith-Wiedemann syndrome with multi-locus imprintin…
A Primary Evaluation of Potential Small-Molecule Inhibitors of the Astacin Metalloproteinase Ovastacin, a Novel Drug Target in Female Infertility Tre…
2020
Abstract Despite huge progress in hormonal therapy and improved in vitro fertilization methods, the success rates in infertility treatment are still limited. A recently discovered mechanism revealed the interplay between the plasma protein fetuin‐B and the cortical granule‐based proteinase ovastacin to be a novel key mechanism in the regulation of fertilization. Upon sperm–egg fusion, cleavage of a distinct zona pellucida component by ovastacin destroys the sperm receptor, enhances zona robustness, and eventually provides a definitive block against polyspermy. An untimely onset of this zona hardening prior to fertilization would consequently result in infertility. Physiologically, this proc…
Reply of the Authors: Hysteroscopic resection of the uterine septum: is it always a necessity?
2009
[No abstract available]
Rescue of ovarian function: stem cells and regenerative factors
2022
El envejecimiento y otras condiciones de daño adquiridas, como los tratamientos oncológicos, conducen a un deterioro de la función ovárica. Sin embargo, incluso cuando los ovarios dañados pierden su capacidad de ovular, permanece un conjunto residual de folículos quiescentes que podrían ser rescatados y desarrollados en un nicho ovárico adecuado, dando lugar a ovocitos maduros. Los factores solubles secretados por las células madre podrían proporcionar un entorno ovárico adecuado para mantener y promover el crecimiento folicular. Por lo tanto, la presente tesis doctoral tuvo como objetivo evaluar los efectos regenerativos de diferentes fuentes de factores secretados por células madre en mod…