Search results for "Fendiline"

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Inhibition by Fendiline of the Transient Outward Current in Rat Ventricular Cardiomyocytes

1999

The effects of fendiline on the transient outward current (Ito) were investigated in rat ventricular cardiomyocytes. Extracellularly applied fendiline reduced peak and steady-state current amplitude of Ito; the inactivation of Ito was accelerated by the drug, which reflects onset of block. The described effects were concentration dependent: half-maximal effects were achieved at approximately 3 microM fendiline. Intracellularly applied fendiline (3 microM) did not affect Ito within 5 min. The steady-state current amplitude of Ito was more efficiently suppressed by the drug at 22 +/- 1 degrees C than at 36 +/- 1 degrees C. The recovery of Ito was analyzed by the application of twin depolarizi…

Malemedicine.medical_specialtyPatch-Clamp TechniquesPotassium ChannelsHeart Ventriclesmedicine.medical_treatmentIn Vitro TechniquesAntiarrhythmic agentdigestive systemMembrane PotentialsRats Sprague-DawleyInternal medicinemedicineAnimalsMyocytePharmacologyCardiac transient outward potassium currentBinding SitesFendilineDose-Response Relationship DrugPulse (signal processing)ChemistryTime constantDepolarizationElectric StimulationRatsIon ExchangeElectrophysiologyEndocrinologyFendilineBiophysicsFemaleCalcium ChannelsCardiology and Cardiovascular MedicineJournal of Cardiovascular Pharmacology

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