Search results for "Fiber"
showing 10 items of 2343 documents
Murine muscle engineered from dermal precursors: an in vitro model for skeletal muscle generation, degeneration and fatty infiltration.
2013
Skeletal muscle can be engineered by converting dermal precursors into muscle progenitors and differentiated myocytes. However, the efficiency of muscle development remains relatively low and it is currently unclear if this is due to poor characterization of the myogenic precursors, the protocols used for cell differentiation, or a combination of both. In this study, we characterized myogenic precursors present in murine dermospheres, and evaluated mature myotubes grown in a novel three-dimensional culture system. After 5-7 days of differentiation, we observed isolated, twitching myotubes followed by spontaneous contractions of the entire tissue-engineered muscle construct on an extracellul…
Effect of Sheep Wool Fibers on Thermal Insulation and Mechanical Properties of Cement-Based Composites
2019
The use of sheep wool as a filler of cement in order to produce mortar or plaster involves several advantages for environment and energy. Moreover, it is considered as a waste and, therefore, its use is characterized by low cost. The aim of this paper is to evaluate the influence of wool fibers on thermal conductivity and mechanical properties of cement. The samples were prepared using wool fibers, obtained from a breed of Sicilian sheep, with three different lengths (i.e., 1, 6, and 20 mm). Furthermore, in order to evaluate the influence of fiber content, the samples were prepared by varying the fiber weight fraction. The thermal conductivity of the samples was analyzed by using a heat flo…
Bond strength according to the moment of fiber post cutting fixed with self-adhesive cement to the root dentin
2021
Background The fiber posts require a cut in the coronal portion to adjust it to the available clinical space. The cutting of posts cemented may generate tension via bur vibrations of drill on the bonding interface, with the possibility of decreasing the bond strength. Thus, this study aimed to evaluate if the moment of cutting the fiber posts has an effect on its bond strength when fixed with self-adhesive resin cement. Material and methods Thirty-six bovine teeth were randomly divided into three groups after endodontic treatment and post space preparation (n = 12): IAC- the fiber posts were cutting immediately after cementation; ACR - the fiber posts were cutting after coronal reconstructi…
Experimental results of RC columns strengthnened with Fiber Reinforced Cementitious Mortars
2012
The structural behaviour of reinforced concrete columns strengthened with a system made up of fibre nets embedded in an inorganic stabilized cementitious matrix was investigated. Specimens with circular and square cross-section were cast and subjected to monotonic uniaxial compression to investigate the efficiency of a Polypara-phenylene-benzo-bisthiazole (PBO) Fibre Reinforced Cementitious Mortars (FRCM) system in increasing both carrying capacity and ductility. The experimental results show that confinement with PBO fibre produced a noticeable increment in strength and ductility, though the low mechanical ratios of fibre considered were not always able to ensure hardening behaviour up to …
Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors
2007
Although endocannabinoids constitute one of the first lines of defense against pain, the anatomical locus and the precise receptor mechanisms underlying cannabinergic modulation of pain are uncertain. Clinical exploitation of the system is severely hindered by the cognitive deficits, memory impairment, motor disturbances and psychotropic effects resulting from the central actions of cannabinoids. We deleted the type 1 cannabinoid receptor (CB1) specifically in nociceptive neurons localized in the peripheral nervous system of mice, preserving its expression in the CNS, and analyzed these genetically modified mice in preclinical models of inflammatory and neuropathic pain. The nociceptor-spec…
The muscleblind gene participates in the organization of Z-bands and epidermal attachments of Drosophila muscles and is regulated by Dmef2.
1998
We report the embryonic phenotype of muscleblind (mbl), a recently described Drosophila gene involved in terminal differentiation of adult ommatidia. mbl is a nuclear protein expressed late in the embryo in pharyngeal, visceral, and somatic muscles, the ventral nerve cord, and the larval photoreceptor system. All three mbl alleles studied exhibit a lethal phenotype and die as stage 17 embryos or first instar larvae. These larvae are partially paralyzed, show a characteristically contracted abdomen, and lack striation of muscles. Our analysis of the somatic musculature shows that the pattern of muscles is established correctly, and they form morphologically normal synapses. Ultrastructural a…
Bond strength evaluation of the veneering-core ceramics bonds.
2009
The purpose of this study was to determine whether the bond of veneering porcelain to a ceramic core in bilayered ceramics was similar to that of the metal ceramic control of well known behaviour. Six groups of nine specimens each were fabricated, whose dimensions were 15 mm long and 8 mm in diameter at the core, and 2 mm long and 8 mm in diameter for the veneer. The groups were GR. 1 (control group): CrNi alloy/d.SIGN (Ivoclar), GR. 2: IPS e.maxPress/IPS e.maxCeram (Ivoclar), GR. 3: IPS e.maxZirCad/ IPS e.maxZirPress (Ivoclar), GR. 4: IPS e.maxZirCad/IPS e.maxCeram (Ivoclar), GR. 5: Lava Frame (3M ESPE)/ Lava Ceram (3M ESPE) and GR. 6: Lava Frame (3M ESPE)/IPS e.maxCeram (Ivoclar). A shear…
Purkinje cell loss and motor coordination defects in profilin1 mutant mice.
2012
Profilin1 is an actin monomer-binding protein, essential for cytoskeletal dynamics. Based on its broad expression in the brain and the localization at excitatory synapses (hippocampal CA3-CA1 synapse, cerebellar parallel fiber (PF)-Purkinje cell (PC) synapse), an important role for profilin1 in brain development and synapse physiology has been postulated. We recently showed normal physiology of hippocampal CA3-CA1 synapses in the absence of profilin1, but impaired glial cell binding and radial migration of cerebellar granule neurons (CGNs). Consequently, brain-specific inactivation of profilin1 by exploiting conditional mutants and Nestin-mediated cre expression resulted in a cerebellar hyp…
Microsurgical Anatomy of the Insular Region and Operculoinsular Association Fibers and its Neurosurgical Application
2019
Objective To analyze the three-dimensional relationships of the operculoinsular compartments, using standard hemispheric and white matter fiber dissection and review the anatomy of association fibers related to the operculoinsular compartments of the Sylvian fissure and the main white matter tracts located deep into the insula. The secondary aim of this study was to improve the knowledge on this complex region to safely address tumor, vascular, and epilepsy lesions with an integrated perspective of the topographic and white matter fiber anatomy using 2D and 3D photographs. Methods Six cadaveric hemispheres were dissected. Two were fixed with formalin and the arteries were injected with red …
Numerical investigations of single mode gyrotron equation
2009
A stationary problem with the integral boundary condition arising in the mathematical modelling of a gyrotron is numerically investigated. The Chebyshev's polynomials of the second kind are used as the tool of calculations. The main result with physical meaning is the possibility to determine the maximal value of electrons efficiency. First published online: 14 Oct 2010