Search results for "Fibril"
showing 10 items of 836 documents
Role of electrostatic interactions in the fibrillogenesis of lysozyme
2011
Integrin-mediated Cell Adhesion to Type I Collagen Fibrils
2004
In the integrin family, the collagen receptors form a structurally and functionally distinct subgroup. Two members of this subgroup, α1β1 and α2β1 integrins, are known to bind to monomeric form of type I collagen. However, in tissues type I collagen monomers are organized into large fibrils immediately after they are released from cells. Here, we studied collagen fibril recognition by integrins. By an immunoelectron microscopy method we showed that integrin α2I domain is able to bind to classical D-banded type I collagen fibrils. However, according to the solid phase binding assay, the collagen fibril formation appeared to reduce integrin α1I and α2I domain avidity to collagen and to lower …
Efectos electrofisiológicos intrínsecos del ejercicio físico crónico sobre el miocardio ventricular normóxico y tras isquemia regional aguda: implica…
2021
Se ha investigado en corazones de conejo aislados, perfundidos y en fibrilación ventricular (sin interrumpir la perfusión global) en situación de perfusión normalmente oxigenada y durante isquemia regional, el efecto de la aplicación de un protocolo de ejercicio físico sobre la refractariedad ventricular, la heterogeneidad electrofisiológica y la reversibilidad de la fibrilación tras la aplicación de choques eléctricos de ondas bifásicas (durante la isquemia regional). Han sido investigados, en otro grupo de conejos y con la misma metodología para el aislamiento del corazón, en normoxia y durante isquemia regional, el efecto de la infusión del bloqueante del canal KATP, glibenclamida, sobre…
(E)-2-cyano-3-(5'-piperidin-1-yl-2,2'-bithien-5-yl)acrylic acid: a new fluorescent probe for detecting prefibrillar oligomers
2013
Goodpasture antigen-binding protein (GPBP) y su efector GPBP-interacting protein de 130-kDa (GIP130) dirigen la formación de miofibrillas
2014
Goodpasture antigen-binding protein (GPBP) es una proteína cinasa no convencional que regula la organización del colágeno IV de la membrana basal glomerular, y de la que existen al menos tres isoformas: GPBP-1 que es soluble y exportable; GPBP-2 que es citosólica y se genera por procesamiento alternativo de exones; y GPBP-3 que está asociada a membranas y regula la secreción de GPBP-1. El gen que expresa las proteínas GPBP (COL4A3BP) tiene notable expresión en tejido muscular, en el que GPBP-1 es la isoforma mayoritaria y se encuentra en la línea M de la banda A de las miofibrillas. Durante la miogénesis de mioblastos C2C12 en cultivo hay una progresiva disminución de la expresión de GPBP-2…
In vitro testing the potential of a novel chimeric igg variant for inhibiting collagen fibrils formation in recurrent hereditary gingival fibromatosi…
2014
Gingival fibromatosis is a progressive enlargement of the gingiva. It may hinder oral cavity hygiene and result in underlying bone loss. The long-term benefits of surgery cannot be predicted. On the other hand, alternative, efficient and non-invasive methods are not available at present. The aim of this study was to test the inhibitory effects of a chimeric IgG variant on collagen fibril formation in the cell culture of gingival fibroblasts taken from a patient with hereditary gingival fibromatosis with a high propensity for recurrence. Gingival biopsies were collected from the mandibular gingiva and used for histological evaluation as well as to establish a fibroblast culture. A histologic…
Implication du récepteur 5-HT4 cardiaque humain dans la fibrillation auriculaire : rôle d’auto-anticorps dirigés contre ce récepteur ?
2004
The human cardiac 5-HT4 receptor was cloned in 1997. It is functional only in atrial myocytes where it is positively coupled via Gs to the adenylate cyclase, activates the cAMP-dependent protein kinase (PKA) and in consequence phosphorylates a variety of intracellular proteins implicated in excitation-contraction coupling. A number of studies suggest a role for the 5-HT4 receptor in the maintenance or elongation of atrial fibrillation. It is now accepted that certain cardiac pathologies involve auto-immune processes. Antibodies directed against the second extracellular loop of a number of cardiac G-protein linked receptors have been found. The human cardiac 5-HT4 receptor could therefore al…
In-hospital and long-term prognosis in patients after implantation of implantable cardioverter-defibrillators and cardiac resynchronization therapy: …
2018
Introduction During the last 20 years, there has been a considerable increase in the number of implanted implantable cardioverter‑defibrillator (ICD) and cardiac resynchronization therapy (CRT) devices. However, there have been only single reports on clinical events, including rehospitalizations, in the long‑term follow‑up. Objectives We analyzed the baseline clinical characteristics, medical procedures used, and complications of patients with implantation of an ICD or CRT device. Moreover, we analyzed the causes of rehospitalization and the types of treatment used in the 12‑month follow‑up. Patients and methods Out of 1 208 440 hospitalizations of patients with cardiovascular diseases incl…
[Is ICD-programming for double intraoperative defibrillation threshold energy safe and effective during long-time follow-up? Results of a prospective…
1999
The aim of this prospective and randomized study was to evaluate the safety and efficacy of a reduced shock strength in transvenous implantable defibrillator therapy. So far clinical data concerning the safety margin of the shock energy in ICD therapy do not exist. The shock energy tested during long-term follow-up in this study was twice the intraoperatively measured defibrillation threshold (DFT). A total number of 176 consecutive patients representing a typical cohort of ICD patients were evaluated. All patients received a non-thoracotomy lead system (CPI, Endotak 0070, 0090) and a biphasic cardioverter-defibrillator with the ability to store episodes (Cardiac Pacemakers Inc., Ventac TM …