Search results for "Fibrocyte"

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Roflumilast N- oxide combined with sildenafil reverses cellular remodeling on IPF models

2017

Background: Idiopathic pulmonary fibrosis (IPF) is characterized by a rapid progressive lung decline and premature death after its diagnosis. Roflumilast displayed anti-fibrotic effects in animal and cellular models. Recent studies indicate that the combination of PDE4 and PDE5 inhibitors (sildenafil) potentiates anti-fibrotic properties of each drug, suggesting potential beneficts of this combination. Objectives: To study the effects from adding sildenafil to roflumilast N-oxide (RNO) inhibiting TGFβ1-induced human alveolar type II (AECII) epithelial-to-mesenchymal transition (EMT) and human fibrocyte to myofibroblast transition in vitro. Methods: AECII and fibrocytes were isolated from he…

biologybusiness.industrySildenafilMesenchymal stem cellVimentinrespiratory tract diseaseschemistry.chemical_compoundchemistryAnnexinFibrocyteCancer researchbiology.proteinMedicineViability assaybusinessMyofibroblastRoflumilastmedicine.drugAirway Pharmacology and Treatment

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