Search results for "Fibroid"

showing 10 items of 26 documents

Myomectomy in infertile women: More harm than good?

2023

Adhesion formation following gynecological surgery remains a challenge. The adoption of minimally invasive surgical approaches, such as conventional or robotic-assisted laparoscopy combined with meticulous microsurgical principles and the application of adhesion–reducing substances, is able to reduce the risk of de novo adhesion formation but do not eliminate it entirely. Myomectomy is the most adhesiogenic surgical procedure and postoperative adhesions can have a significant impact on the ability to conceive. Therefore, when surgery is performed as infertility treatment, attention should be paid to whether the benefits outweigh the risks. Among several factors, the size and the location of…

InfertilityAdhesionLaparoscopySurgeryUterine fibroids.Settore MED/40 - Ginecologia E OstetriciaMyomectomyFrontiers in Surgery
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Reproductive and Obstetric Outcomes after UAE, HIFU, and TFA of Uterine Fibroids: Systematic Review and Meta-Analysis

2023

Novel treatment options for uterine fibroids, such as uterine artery embolization (UAE), ultrasound-guided and magnetic resonance-guided high-intensity focused ultrasound (USgHIFU and MRgHIFU), and transcervical radiofrequency ablation (TFA) methods, are widely used in clinical practice. This systematic review and meta-analysis (CRD42022297312) aims to assess and compare reproductive and obstetric outcomes in women who underwent these minimally invasive approaches for uterine fibroids. The search was performed in PubMed, Google Scholar, ScienceDirect, Cochrane Library, Scopus, Web of Science and Embase. Risk of bias was assessed using the Newcastle–Ottawa Scale (NOS) and Cochrane guidelines…

MRgHIFU UAE USgHIFU Leiomyoma Pregnancy Transcervical radiofrequency ablation Uterine fibroidsHealth Toxicology and MutagenesisPublic Health Environmental and Occupational HealthSettore MED/40 - Ginecologia E OstetriciaInternational Journal of Environmental Research and Public Health
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Immunohistochemical Expression of Vitamin D Receptor in Uterine Fibroids

2022

One of the many factors involved in the development of uterine fibroids is vitamin D deficiency. One aspect of this deficiency is decreased serum concentration of calcidiol-25(OH)D, a metabolite of D3 vitamin. The active form of vitamin D3, which arises after numerous enzymatic reactions, is calcitriol-1,25(OH)2D3; this compound is transported to various body tissues. Vitamin D possesses extra-genomic effects due to its influence on various signaling pathways, i.e., through activating tyrosine kinases and by genomic effects via binding to a specific nuclear receptor, vitamin D receptor (VDR). The vitamin D/VDR complex regulates the expression of genes and is involved in the pathogenesis of …

Nutrition and DieteticsLeiomyomauterine fibroids; vitamin D; vitamin D receptor (VDR)HumansReceptors CalcitriolFemaleVitamin DVitamin D DeficiencyImmunohistochemistryFood ScienceCholecalciferolNutrients
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Laparoscopic subtotal hysterectomy followed by in-bag transvaginal corpus uteri morcellation and extraction: A case series

2023

Objectives: Laparoscopic subtotal hysterectomy (LSH) is a possible treatment for patients with benign uterine disease. Once the hysterectomy has been completed, morcellation and extraction of the corpus uteri is a crucial step of the procedure. We here present a case series to evaluate the feasibility of the in-bag transvaginal specimen retrieval following LSH. Study design: We report a case series of consecutive patients who underwent LSH followed by in-bag transvaginal specimen retrieval. LSH was accomplished in a standard fashion. Once the uterus was detached from the cervix, a 2 cm posterior colpotomy was performed laparoscopically with a monopolar hook under direct view to insert a spe…

Reproductive MedicineFibroidMinimally invasive surgeryObstetrics and GynecologySupracervical hysterectomy.Specimen retrievalMorcellationSettore MED/40 - Ginecologia E OstetriciaEndo-bag
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Introduction

2014

The cellular, genetic, and hormonal understanding of uterine fibroids is rapidly growing, but the therapeutic options remain similar. Are we really advancing the field?

Reproductive MedicineUterine fibroidsbusiness.industrymedicineObstetrics and Gynecologymedicine.diseaseBioinformaticsbusinessfemale genital diseases and pregnancy complicationsFertility and Sterility
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MRgFUS Uterine Fibroids treatments in Sicily: Preliminary Results and comparison of a Semi-Automatic and manual contouring

2013

Background: Traditional surgery for uterine fibroids treatments (e.g. myomectomy, hysterectomy) offers very invasive therapeutic approaches, which not always preserve reproductive potential of the woman. MRgFUS (MR guided Focused UltraSound) is a new and non-invasive technique for uterine fibroids treatment, not requiring hospitalization and recovery time [1]. On June 2011 and July 2012 the first treatments were started at HSR-Giglio Hospital in Cefalù and at University Hospital (DIBIMEF) in Palermo. An initial assessment of MRgFUS treatment was made by computing the thermally-ablated volume of uterine fibroid. This volume was evaluated considering the NPV (Non Perfused Volume) on a post-t…

Settore ING-INF/05 - Sistemi Di Elaborazione Delle InformazioniMRgFUS uterine fibroids segmentationSettore MED/36 - Diagnostica Per Immagini E Radioterapia
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Combining split-and-merge and multi-seed region growing algorithms for uterine fibroid segmentation in MRgFUS treatments

2016

Uterine fibroids are benign tumors that can affect female patients during reproductive years. Magnetic resonance-guided focused ultrasound (MRgFUS) represents a noninvasive approach that uses thermal ablation principles to treat symptomatic fibroids. During traditional treatment planning, uterus, fibroids, and surrounding organs at risk must be manually marked on MR images by an operator. After treatment, an operator must segment, again manually, treated areas to evaluate the non-perfused volume (NPV) inside the fibroids. Both pre- and post-treatment procedures are time-consuming and operator-dependent. This paper presents a novel method, based on an advanced direct region detection model, …

SpeedupUterine fibroidsImage ProcessingBiomedical EngineeringThermal ablation02 engineering and technologyMagnetic Resonance Imaging InterventionalFocused ultrasound030218 nuclear medicine & medical imaging03 medical and health sciencesComputer-Assisted0302 clinical medicineImage Processing Computer-Assisted0202 electrical engineering electronic engineering information engineeringmedicineHumansSegmentationRadiation treatment planningSplit-and-merge segmentationSettore ING-INF/05 - Sistemi Di Elaborazione Delle InformazioniMRgFUS treatmentsInterventionalLeiomyomaMulti-seed adaptive region growingbusiness.industrymedicine.diseaseMagnetic Resonance Imagingfemale genital diseases and pregnancy complicationsComputer Science ApplicationsAutomatic segmentation MRgFUS treatments Multi-seed adaptive region growing Split-and-merge segmentation Uterine fibroids Algorithms Female High-Intensity Focused Ultrasound Ablation Humans Leiomyoma Magnetic Resonance Imaging Magnetic Resonance Imaging Interventional Image Processing Computer-AssistedMRgFUS treatmentRegion growingAutomatic segmentation; MRgFUS treatments; Multi-seed adaptive region growing; Split-and-merge segmentation; Uterine fibroids; Algorithms; Female; High-Intensity Focused Ultrasound Ablation; Humans; Leiomyoma; Magnetic Resonance Imaging; Magnetic Resonance Imaging Interventional; Image Processing Computer-AssistedHigh-Intensity Focused Ultrasound AblationFemale020201 artificial intelligence & image processingAutomatic segmentationbusinessMerge (version control)AlgorithmAlgorithmsUterine fibroidsMedical & Biological Engineering & Computing
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SINGLE CELL TRANSCRIPTOMES FROM UTERINE FIBROIDS AND FIBROID-FREE MYOMETRIUM ELUCIDATE MYOMETRIAL TUMORIGENESIS

2020

Transcriptomemedicine.anatomical_structureReproductive MedicineUterine fibroidsCellmedicineMyometriumCancer researchObstetrics and GynecologyBiologyCarcinogenesismedicine.disease_causemedicine.diseaseFertility and Sterility
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Impact of FIGO type 3 uterine fibroids on in vitro fertilization outcomes: A systematic review and meta‐analysis

2023

Background: The effect of FIGO (the International Federation of Gynecology & Obstetrics) type 3 myomas on in vitro fertilization (IVF) is uncertain. Objectives: To evaluate whether FIGO type 3 myomas affect IVF outcomes, through a systematic review and meta-analysis (CRD42022379700). Search strategy: Electronic databases were searched until November 15, 2022. Selection criteria: Studies evaluating the effects of FIGO type 3 myomas on IVF outcome. Data collection and analysis: Pooled results were expressed as odds ratios (OR) with 95% confidence intervals (CI). Heterogeneity was assessed using Higgins I2 . Sources of heterogeneity were explored with sensitivity and subgroup analyses. Mai…

Type 3 myomaFibroidInfertilityObstetrics and GynecologyfibroidsHysteroscopyGeneral MedicineSettore MED/40 - Ginecologia E OstetriciaIn vitro fertilization (IVF)International Journal of Gynecology & Obstetrics
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Guidelines for biomarker discovery in endometrium: correcting for menstrual cycle bias reveals new genes associated with uterine disorders

2021

Abstract Transcriptomic approaches are increasingly used in reproductive medicine to identify candidate endometrial biomarkers. However, it is known that endometrial progression in the molecular biology of the menstrual cycle is a main factor that could affect the discovery of disorder-related genes. Therefore, the aim of this study was to systematically review current practices for considering the menstrual cycle effect and to demonstrate its bias in the identification of potential biomarkers. From the 35 studies meeting the criteria, 31.43% did not register the menstrual cycle phase. We analysed the menstrual cycle effect in 11 papers (including 12 studies) from Gene Expression Omnibus: t…

endometriosisEmbryologyUterine fibroidsmedia_common.quotation_subjectmenstrual cycle progressionEndometriosisBiologyBioinformaticsEndometriumdifferential expressionEndometriumendometrial pathologiesGeneticsmedicineHumansuterine fibroidsBiomarker discoveryMolecular Biologytranscriptomic analysisMenstrual CycleMenstrual cycleOriginal Researchrecurrent implantation failuremedia_commonUterine Diseasesrecurrent pregnancy lossObstetrics and GynecologyCell Biologymedicine.diseaseAcademicSubjects/MED00905Uterine DisorderMenstrual cycle phaseconfounding variablemedicine.anatomical_structureReproductive Medicinegene expressionOvarian EndometriosisFemaleTranscriptomeDevelopmental BiologyMolecular Human Reproduction
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