Search results for "Fibrosis"
showing 10 items of 901 documents
Histopathological progression of hidradenitis suppurativa/acne inversa
2021
It is generally acknowledged that the first morphological change of hidradenitis suppurativa/acne inversa (HS/AI) consists of infundibular plugging of the folliculosebaceous apocrine apparatus, which is followed by acute and chronic inflammation, cysts with sinus formation, and fibrosis. Alternatively, it has been hypothesized that HS/AI is primarily a neutrophilic autoinflammatory disease and that the follicular plugging typical of this disease is secondary to inflammation.To review the sequence of the changes that mark the disease development, we have performed a histopathologic study on the surgical material from a series of axillary and inguinal/perineal cases.The histologic material fr…
Atrial Fibrosis Hampers Non-invasive Localization of Atrial Ectopic Foci From Multi-Electrode Signals: A 3D Simulation Study
2018
[EN] Introduction: Focal atrial tachycardia is commonly treated by radio frequency ablation with an acceptable long-term success. Although the location of ectopic foci tends to appear in specific hot-spots, they can be located virtually in any atrial region. Multi-electrode surface ECG systems allow acquiring dense body surface potential maps (BSPM) for non-invasive therapy planning of cardiac arrhythmia. However, the activation of the atria could be affected by fibrosis and therefore biomarkers based on BSPM need to take these effects into account. We aim to analyze the effect of fibrosis on a BSPM derived index, and its potential application to predict the location of ectopic foci in the …
Combined Bacteriophage and Antibiotic Treatment Prevents Pseudomonas aeruginosa Infection of Wild Type and cftr- Epithelial Cells
2020
International audience; With the increase of infections due to multidrug resistant bacterial pathogens and the shortage of antimicrobial molecules with novel targets, interest in bacteriophages as a therapeutic option has regained much attraction. Before the launch of future clinical trials, in vitro studies are required to better evaluate the efficacies and potential pitfalls of such therapies. Here we studied in an ex vivo human airway epithelial cell line model the efficacy of phage and ciprofloxacin alone and in combination to treat infection by Pseudomonas aeruginosa. The Calu-3 cell line and the isogenic CFTR knock down cell line (cftr-) infected apically with P. aeruginosa strain PAO…
Extensive molecular analysis of patients bearing CFTR-related disorders.
2012
Cystic fibrosis transmembrane conductance regulator (CFTR)–related disorders (CFTR-RDs) may present with pancreatic sufficiency, normal sweat test results, and better outcome. The detection rate of mutations is lower in CFTR-RD than in classic CF: mutations may be located in genes encoding proteins that interact with CFTR or support channel activity. We tested the whole CFTR coding regions in 99 CFTR-RD patients, looking for gene mutations in solute carrier (SLC) 26A and in epithelial Na channel (ENaC) in 33 patients who had unidentified mutations. CFTR analysis revealed 28 mutations, some of which are rare. Of these mutations, RT-PCR demonstrated that the novel 1525-1delG impairs exon 10 s…
Small heat shock proteins and the cytoskeleton: an essential interplay for cell integrity?
2012
Abstract The cytoskeleton is a highly complex network of three major intracellular filaments, microfilaments (MFs), microtubules (MTs) and intermediate filaments (IFs). This network plays a key role in the control of cell shape, division, functions and interactions in animal organs and tissues. Dysregulation of the network can contribute to numerous human diseases. Although small HSPs (sHSPs) and in particular HSP27 (HSPB1) or αB-crystallin (HSPB5) display a wide range of cellular properties, they are mostly known for their ability to protect cells under stress conditions. Mutations in some sHSPs have been found to affect their ability to interact with cytoskeleton proteins, leading to IF a…
European consensus on grading bone marrow fibrosis and assessment of cellularity.
2005
Quantification of characteristic bone marrow biopsy features includes basic parameters such as cellularity and fiber content. These are important to assess the dynamics of disease processes with a significant impact on risk stratification, survival patterns and, especially, therapy-related changes. A panel of experienced European pathologists and a foreign expert evaluated, at a multi-headed microscope, a large number of representative slides of trephine biopsies from patients with myelofibrosis in an attempt to reach a consensus on how to grade cellularity and fibrosis. This included a critical evaluation of previously described scoring systems. During the microscopic analysis and subseque…
Estudio de la transformación fibroblasto-miofibroblasto, la senescencia y el metabolismo de fibroblastos aislados de pacientes con fibrosis pulmonar …
2021
La Fibrosis Pulmonar idiopática (FPI) está definida como una neumonía intersticial fibrosante crónica de causa desconocida, progresiva y fatal que afecta fundamentalmente a adultos mayores de 60 años, limitada a los pulmones y asociada con el patrón histopatológico de neumonía intersticial usual (NIU). La ausencia de manifestaciones específicas de la FPI supone un obstáculo para su detección temprana. Es una enfermedad de diagnóstico difícil y tardío, con un abordaje terapéutico de eficacia reducida. Estas características suscitan la necesidad de encontrar nuevos biomarcadores asociados a la fibrosis y nuevas dianas terapéuticas para un diagnóstico temprano e incrementar la calidad y espera…
What are the risk and protective factors for the well-being of adolescents with CF?
2021
La fibrosis quística (FQ) es una enfermedad crónica y hereditaria que compromete la vida de quienes la padecen, y se hace especialmente importante su impacto en la adolescencia. El afrontamiento que estos pacientes y sus familiares hagan de estas circunstancias que les han tocado vivir, puede mejorar o empeorar el curso y desenlace de la enfermedad. El objetivo es conocer los factores de riesgo y protectores que influyen en el bienestar de los adolescentes con FQ. Para ello se realizó una búsqueda bibliográfica de la literatura científica siguiendo la guía PRISMA en las siguientes bases de datos: Web of Science, ProQuest y Scopus. Se incluyeron artículos centrados en factores psicológicos d…
Inclusión laboral y discapacidad invisible. Hacia una reflexión sobre las barreras y posibilidades del mercado laboral ordinario. El caso de las pers…
2021
Este trabajo tiene como objetivo analizar la situación laboral de las personas con fibrosis quística en España, con qué barreras se encuentran en el acceso y mantenimiento del empleo y qué adaptaciones favorecerían la inserción. Los datos se obtuvieron de una muestra de 368 personas con fibrosis quística residentes en España de entre 16 y 60 años. Se utilizó una metodología mixta combinando encuestas, entrevistas y un grupo de discusión. Los hallazgos sugieren que la rigidez del mercado de trabajo ordinario no protegido y la invisibilidad de la discapacidad, derivada de esta enfermedad, suponen barreras para compatibilizar trabajo y cuidados. Las conclusiones apuntan, como elementos facilit…
Intervención nutricional en niños y adolescentes con fibrosis quística. Relación con la función pulmonar
2005
Cecilia.Martinez@uv.es; Francisco.Nunez@uv.es; Objetivo: Evaluar los efectos de la intervención nutricional precoz y continuada en pacientes pediátricos con fibrosis quística (FQ) y su posible implicación en la función pulmonar. Pacientes y métodos: Se incluyen el seguimiento de 19 pacientes con FQ (11 niñas, 8 niños) de 17 meses a 18 años de edad y promedio de 10 años de enfermedad. El genotipo de 16 pacientes es delta F 508 (10 homo, 6 heterocigotos). Cada 2-3 meses se les ha realizado: valoración clínica, dietética y antropométrica clasificando el estado de nutrición (EN) según Z pesto/talla, % peso para la talla, índice de masa corporal y Z talla/edad. Coincidentemente se obtuvo cultivo…