Search results for "Figura"
showing 10 items of 867 documents
Novel σ1 antagonists designed for tumor therapy: Structure – activity relationships of aminoethyl substituted cyclohexanes
2021
Abstract Depending on the substitution pattern and stereochemistry, 1,3-dioxanes 1 with an aminoethyl moiety in 4-position represent potent σ1 receptor antagonists. In order to increase the stability, a cyclohexane ring first replaced the acetalic 1, 3-dioxane ring of 1. A large set of aminoethyl substituted cyclohexane derivatives was prepared in a six-step synthesis. All enantiomers and diastereomers were separated by chiral HPLC at the stage of the primary alcohol 7, and their absolute configuration was determined by CD spectroscopy. Neither the relative nor the absolute configuration had a large impact on the σ1 affinity. The highest σ1 affinity was found for cis-configured benzylamines…
Evaluation of different InSAR multi-baseline construction methods over a dam in southern Italy
2018
Monitoring dam displacements using different techniques allows an evaluation of their structural behaviour over time. In this study, dam displacements (for the Castello dam, Agrigento, Italy) have been investigated using different Interferometric Synthetic Aperture Radar (InSAR) techniques exploiting a freely available dataset from the EU Copernicus Sentinel-1 SAR built by the European Space Agency (ESA). The dataset includes Sentinel 1A (S1A) images acquired in dual-polarization and Interferometric Wide (IW) swath using the Terrain Observation with Progressive Scans SAR (TOPSAR) mode. Three main Multi-Baseline Construction methods based on the identification of Persistent Scatterers (PS) h…
Das Unheimliche (Postcolonialisme et reconfiguration à l'extrême gauche). Autour d'une configuration, à partir de : Race et Capitalisme, Les Cahiers …
2013
International audience; Pourquoi ce titre, emprunté à Sigmund Freud1, pourquoi à propos d'une livraison pour Syllepse d'un numéro des Cahiers de l'émancipation ? Le propos n'est pas une lecture pathologique, mais davantage symptomale, soit une façon – à la manière assumée d'un usage « sauvage » du lexique psychanalytique tel que pratiquée naguère par l'histoire du temps présent – de questionner une part de l'agency 2 de l'extrême gauche française contemporaine, entre stratégie(s) académique(s), reconfiguration(s) politique(s) autour des questions du postcolonialisme, du marxisme et de son efficace politique sur la scène française. Cette livraison offre un dossier « Race et capitalisme » coo…
The HisClima database: historical weather logs for automatic transcription and information extraction
2021
Knowing the weather and atmospheric conditions from the past can help weather researchers to generate models like the ones used to predict how weather conditions are likely to change as global temperatures continue to rise. Many historical weather records are available from the past registered on a systemic basis. Historical weather logs were registered in ships, when they were on the high seas, recording daily weather conditions such as: wind speed, temperature, coordinates, etc. These historical documents represent an important source of knowledge with valuable information to extract climatic information of several centuries ago. This paper presents a database for researching about the ca…
Enhanced β-turn conformational stability of tripeptides containing Δphe in cis over trans configuration
2013
Conformations of three pairs of dehydropeptides with the opposite configuration of the Delta Phe residue, Boc-Gly-Delta(Z/E)Phe-Phe-p-NA (Z- p -NA and E- p -NA), Boc-Gly-Delta(Z/E)Phe-Phe-OMe (Z-OMe and E-OMe), and Boc-Gly-Delta(Z/E)Phe-Phe-OH (Z-OH and E-OH) were compared on the basis of CD and NMR studies in MeOH, TFE, and DMSO. The CD results were used as the additional input data for the NMR-based calculations of the detailed solution conformations of the peptides. It was found that Z- p -NA, E- p -NA, Z-OMe, and Z-OH adopt the beta-turn conformations and E-OMe and E-OH are unordered. There are two overlapping type III beta-turns in Z- p -NA, type II' beta-turn in E- p -NA, and type II …
Ultra-fast intensified frame images from an electron cyclotron resonance hydrogen plasma at 2.45 GHz: some space distributions of visible and monochr…
2014
First results from an ultra-fast frame image acquisition diagnostic coupled to a 2.45 GHz microwave hydrogen discharge are presented. The plasma reactor has been modified to include a transparent doubled shielded quartz window allowing to viewing the full plasma volume. Pictures describing the breakdown process at 1μs exposure time have been obtained for integrated visible light signal, Balmer-alpha, Balmer-beta lines, and Fulcher-band. Several different plasma emission distributions are reported. The distribution depends on the magnetic field configuration, incident microwave power, and neutral gas pressure. peerReviewed
Perturbative treatment of triple excitations in coupled‐cluster calculations of nuclear magnetic shielding constants
1996
A theory for the calculation of nuclear magnetic shielding constants at the coupled‐cluster singles and doubles level augmented by a perturbative correction for connected triple excitations (CCSD(T)) has been developed and implemented. The approach, which is based on the gauge‐including atomic orbital (GIAO) ansatz, is illustrated by several numerical examples. These include a comparison of CCSD(T) and other highly correlated methods with full configuration interaction for the BH molecule, and a systematic comparison with experiment for HF, H2O,NH3, CH4, N2, CO, HCN, and F2. The results demonstrate the importance of triple excitations in establishing quantitative accuracy. Finally, the abil…
Acid-induced rearrangement of epoxygermacra-8,12-olides: synthesis and absolute configuration of guaiane and eudesmane derivatives from artemisiifolin
2010
A study on the acid-induced rearrangement of 4,5-epoxy- and 1,10-epoxygermacra-8,12-olides was carried out. From a 4,5-epoxy derivative, guaianes were obtained, whereas 1,10-epoxy derivatives furnished, depending on the stereochemistry of the C-1/C-10 epoxy ring, trans-5β,10α- or trans-5α,10β-eudesmanolides.
Synthesis of 8-aminomorphans with high KOR affinity
2021
2-Azabicyclo[3.3.1]nonanes (morphans) with a (3,4-dichlorophenyl)acetyl group at 2-position and a pyrrolidino moiety at 8-position were designed as conformationally restricted analogs of piperidine-based KOR agonists. The synthesis started with 4-oxopiperidine-2-carboxylic acid comprising 13 reaction steps. At first the ketone 10 was transformed into diester 7 bearing a propionate side chain. Dieckmann condensation of diester 7 to afford bicyclic enolester 14 and subsequent Krapcho deethoxycarbonylation represent the key steps of the synthesis. The enantiomeric pyrrolidines (1S,5R,8R)-5a and (1R,5S,8S)-5a were separated by chiral HPLC. The eutomer (1S,5R,8R)-5a showed high KOR affinity (K-i…
Selected dissociation‐ and correlation‐consistent configuration interaction by a perturbative criterion
1990
We propose a perturbative criterion to select the most important dissociation‐ or correlation‐consistent type of contributions to perform generalized valence bond‐configuration interaction (GVB‐CI) calculations, dissociation‐consistent configuration interaction (DCCI) or correlation‐consistent configuration interaction (CCCI) approach, respectively. The procedure presented is computationally less demanding than the CCCI proposed by Goddard and co‐workers. To ensure the distance consistency of the MOs used, the nonvalence virtual orbitals are obtained by a projection technique. The results obtained for a few test calculations show the ability of the suggested approach to get close results to…