Search results for "Filter"
showing 10 items of 1019 documents
R-Score: A New Parameter to Assess the Quality of Variants’ Calls Assessed by NGS Using Liquid Biopsies
2021
Next-generation sequencing (NGS) has enabled a deeper knowledge of the molecular landscape in non-small cell lung cancer (NSCLC), identifying a growing number of targetable molecular alterations in key genes. However, NGS profiling of liquid biopsies risk for false positive and false negative calls and parameters assessing the quality of NGS calls remains lacking. In this study, we have evaluated the positive percent agreement (PPA) between NGS and digital PCR calls when assessing EGFR mutation status using 85 plasma samples from 82 EGFR-positive NSCLC patients. According to our data, variant allele fraction (VAF) was significantly lower in discordant calls and the median of the absolute va…
With a Little Help from My Friends: The Role of Intraoperative Fluorescent Dyes in the Surgical Management of High-Grade Gliomas
2018
High-grade gliomas (HGGs) are the most frequent primary malignant brain tumors in adults, which lead to death within two years of diagnosis. Maximal safe resection of malignant gliomas as the first step of multimodal therapy is an accepted goal in malignant glioma surgery. Gross total resection has an important role in improving overall survival (OS) and progression-free survival (PFS), but identification of tumor borders is particularly difficult in HGGS. For this reason, imaging adjuncts, such as 5-aminolevulinic acid (5-ALA) or fluorescein sodium (FS) have been proposed as superior strategies for better defining the limits of surgical resection for HGG. 5-aminolevulinic acid (5-ALA) is i…
Optical method for determining optical brightener concentration in water solution
2006
The field of environmental sensors has been developing driven by the Baltic Sea environmental considerations. The authors propose the use of optical methods for developing sensitive, selective and low cost approach to address water media emitted matter research. An optical method to detect the human anthropogenic load presence in water bodies by measuring minute optical brighteners (OBs) concentration in water due to the laundry effluent is demonstrated. The authors propose to use OBs as a conveniently and affordably detectable optical parameter to compare the levels of human impact on the water bodies studied.
Acousto-optic interaction in biconical tapered fibers: shaping of the stopbands
2016
The effect of a gradual reduction of the fiber diameter on the acousto-optic (AO) interaction is reported. The experimental and theoretical study of the intermodal coupling induced by a flexural acoustic wave in a biconical tapered fiber shows that it is possible to shape the transmission spectrum, for example, substantially broadening the bandwidth of the resonant couplings. The geometry of the taper transitions can be regarded as an extra degree of freedom to design the AO devices. Optical bandwidths above 45 nm are reported in a tapered fiber with a gradual reduction of the fiber down to 70 μm diameter. The effect of including long taper transition is also reported in a double-tapered st…
Q switching and mode locking pulse generation from an all-fiber ring laser by intermodal acousto-optic bandpass modulation
2018
Q-switched and mode-locked (QML) pulse generation from an all-fiber ring laser based on intermodal acousto-optic bandpass modulation is reported. The modulator relies on full-acousto-optic mode re-coupling cycle induced by a standing flexural acoustic wave, with a transmission response that is controlled by amplitude modulation of the acoustic wave signal. The Q factor of the cavity is controlled by a rectangular pulse wave with variable frequency and duty cycle, whereas mode locking is achieved by amplitude modulation derived from a standing flexural acoustic wave. The best QML pulses were obtained at 0.5 kHz repetition rate, with a pump power of 549.2 mW, at the optical wavelength of 1568…
Stable Optically Generated RF Signals from a Fibre Mode-Locked Laser
2010
Phase stability of RF signals obtained by two-mode filtering of a fibre mode-locked laser is analyzed. Time jitter is shown to be constant with selected mode spacing, confirming the scheme capability for generating stable RF signals up to extremely-high frequency.
Tunable microwave photonic filter based on chirped fiber gratings working with a single optical carrier at constant wavelength
2007
This paper presents a tunable transversal filter working with a single optical carrier at constant wavelength. The filter consists of a set of chirped gratings whose time delay is tuned with respect to the emission wavelength of a fiber laser by a piezoelectric actuator; extra lengths of fiber are inserted in the filter arms in order to avoid interferences between signals reflected in different gratings. Two and three taps filters are experimentally demonstrated, the filters transfer function is electronically tuned within the free spectral range.
Advanced Optical Processing of Microwave Signals
2005
The authors present a review on the recent approaches proposed to implement transversal RF filters. Different tunable transversal filters consisting of wavelength tunable optical taps and those employing the tunability of dispersive devices are presented showing their high-performance characteristics. A comprehensive review of the fundamentals and a discussion on the main limitation of these structures are also included.
Experimental study of an in-fiber acousto-optic tunable bandpass filter for single- and dual-wavelength operation in a thulium-doped fiber laser
2019
A tunable single- and dual-wavelength thulium-doped all-fiber laser is demonstrated based on the implementation of an in-fiber acousto-optic tunable bandpass filter (AOTBF). The AOTBF is fabricated to be operated in the 1.9 µm region, and takes advantage of the intermodal coupling effect produced by traveling flexural acoustic waves in an optical fiber. It exhibits a 3-dB bandwidth of 2.04 nm with an insertion loss of 4.75 dB. The tuning properties of the AO device allows a continuous-wave operation with characteristics of wide tuning range (211.5 nm), narrow linewidth (50 pm) and high signal-to-noise ratio (60 dB). In the dual-wavelength regime, the laser is capable of independent tuning o…
Design of a continuously tunable delay line using vectorial modulational instability and chromatic dispersion in optical fibers
2009
International audience; We design an all-optical tunable delay line based on both dispersive and wavelength conversion stages involving modulational instability of a two-frequency pump field propagating in a highly birefringent fiber. More precisely, we numerically show that, by varying the frequency separation between the two orthogonally polarized pump waves, we achieve a controllable and continuous delay of hundreds of picoseconds for signal pulse durations from picoseconds to nanoseconds, without pulse distortion and with only small peak power fluctuations. The proposed method does not require any tunable bandpass filter and can be applied to delay digital data streams at tens of Gbit/s…