Search results for "Flank"

showing 2 items of 22 documents

Militarization of Security Policies in Central and Eastern Europe

2023

Pawłuszko explains the process of militarization of security policies in the CEE region since the Crimea Crisis. According to the Copenhagen School, he focuses on reconstruction of the Central-Eastern European Security Complex and draws attention to the changes in military policies of states in the region. Pawłuszko explores theoretical implications, as well as practical consequences of the NATO-Russia rivalry on the “eastern flank” of Europe. The chapter concludes with a study of perspectives on geopolitical agenda of the CEE region.

NATOEastern flankSecurityPolandMilitarizationCEE
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Genomic structure and functional characterization of the human ADAM10 promoter

2005

The ADAM10 gene encodes a membrane-bound disintegrin-metalloproteinase, which, after overexpression in an Alzheimer disease (AD) mouse model, prevents amyloid pathology and improves long-term potentiation and memory. Because enhancing ADAM10 expression appears to be a reasonable approach for treatment of AD, we functionally analyzed the ADAM10 gene. Both human and mouse ADAM10 genes comprise approximately 160 kbp, are composed of 16 exons, and are evolutionarily highly conserved within 500 bp upstream of either translation initiation site. By using luciferase reporter assays, we demonstrate that nucleotides -2179 to -1 upstream of the human ADAM10 translation initiation site represent a fun…

5' Flanking Region5' flanking regionTretinoinBiologyPolymorphism Single NucleotideBiochemistryCell LineConserved sequenceADAM10 ProteinMiceOpen Reading FramesExonAlzheimer DiseaseGeneticsAnimalsHumansPromoter Regions GeneticMolecular BiologyTranscription factorGeneConserved SequenceExpressed Sequence TagsIntronMembrane ProteinsPromoterExonsMolecular biologyIntronsADAM ProteinsOpen reading frameMutagenesis Site-DirectedAmyloid Precursor Protein SecretasesBiotechnologyThe FASEB Journal
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