Search results for "Fluid therapy"

showing 2 items of 32 documents

Albumin replacement therapy in immunocompromised patients with sepsis - Secondary analysis of the ALBIOS trial

2021

Abstract Background The best fluid replacement strategy and the role of albumin in immunocompromised patients with sepsis is unclear. Methods We performed a secondary analysis of immunocompromised patients enrolled in the ALBIOS trial which randomized patients with severe sepsis or septic shock to receive either 20% albumin (target 30 g per liter or more) and crystalloid or crystalloid alone during ICU stay. Results Of 1818 patients originally enrolled, 304 (16.4%) were immunocompromised. One-hundred-thirty-nine (45.7%) patients were randomized in the albumin while 165 (54.2%) in the crystalloid group. At 90 days, 69 (49.6%) in the albumin group and 89 (53.9%) in the crystalloids group died…

medicine.medical_specialtySepsimedicine.medical_treatmentSocio-culturaleCritical Care and Intensive Care MedicineSepsisAlbumin; Immunocompromised; Immunodeficiency; Sepsis; Septic shock03 medical and health sciencesImmunocompromised Host0302 clinical medicineInternal medicineSepsisAlbuminsSeptic shockmedicineHumansImmunodeficiencyRenal replacement therapyAlbumin; Immunocompromised; Immunodeficiency; Sepsis; Septic shock; Albumins; Crystalloid Solutions; Fluid Therapy; Humans; Immunocompromised Host; Sepsis; Shock SepticImmunocompromisedMechanical ventilationSeptic shockbusiness.industrySepticAlbuminHazard ratioAcute kidney injuryAlbumin030208 emergency & critical care medicineShockCrystalloid Solutionsmedicine.diseaseShock Septic030228 respiratory systemFluid TherapySOFA scorebusiness
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Hyperosmolar therapy for acute brain injury: study protocol for an umbrella review of meta-analyses and an evidence mapping

2020

Introduction Acute brain injury is a challenging public health problem worldwide. Elevated intracranial pressure is a common complication after acute brain injury. Hyperosmolar therapy is one of the main therapeutic strategies for the management of intracranial hypertension. This study protocol outlines an umbrella review of meta-analyses which will investigate the benefits and harms of hyperosmolar therapy routinely used for the management of acute brain injury in the intensive care. Methods and analysis We will search PubMed/MEDLINE, EMBASE and the Cochrane Database of Systematic Reviews. We will include meta-analyses of primary research studies (eg, randomised controlled trials, observat…

meta-analysilaw.inventionAnaesthesia0302 clinical medicineHypertonic salinesystematic reviewlawBrain Injuries TraumaticProtocolMedicineMannitol1506030212 general & internal medicineBrain injuryRandomized Controlled Trials as TopicEvidence-Based MedicineRGeneral MedicineIntensive care unit3. Good healthTreatment OutcomeSystematic reviewResearch DesignMeta-analysisMedicinehyperosmolar therapy1682medicine.medical_specialtyCritical CareMEDLINE03 medical and health sciencesMeta-Analysis as TopicIntensive careHumansHyperosmolar therapyCerebral perfusion pressureIntensive care medicineSaline Solution HypertonicDroitbusiness.industrymannitolbrain injuryHypertonic salinemeta-analysisMeta-analysisSystematic reviewFluid TherapyObservational studyIntracranial Hypertensionbusiness030217 neurology & neurosurgeryhypertonic saline
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