Search results for "Fluoroform"

showing 2 items of 2 documents

CCDC 775515: Experimental Crystal Structure Determination

2011

Related Article: D.Siebler, M.Linseis, T.Gasi, L.M.Carella, R.F.Winter, C.Forster, K.Heinze|2011|Chem.-Eur.J.|17|4540|doi:10.1002/chem.201002101

Space GroupCrystallographyCrystal SystemCrystal StructureCell Parameters1-Fluoroformoyl-1'-(t-butyloxycarbonylamino)ferroceneExperimental 3D Coordinates

researchProduct

Diastereoselective Synthesis of Enantioenriched Trifluoromethylated Ethylenediamines and Isoindolines Containing Two Stereogenic Carbon Centers by Nu…

2020

Fluoroform, HFC-23, is an industrial byproduct from the synthesis of polytetrafluoroethylene and is a vastly underused resource; however, its physicochemical properties have hindered progress toward synthetic uses. Herein, we describe the use of HFC-23 as a cheap trifluoromethylating agent in two reactions for the highly diastereoselective synthesis of medicinally attractive chiral amines with two stereogenic carbon centers: a base-dependent, stereodivergent nucleophilic addition to synthesize enantioenriched vicinal diamines and a tandem nucleophilic addition/aza-Michael sequence toward enantioenriched isoindolines.

chemistry.chemical_compoundNucleophilic additionNucleophilechemistryFluoroformTrifluoromethylationOrganic ChemistryEthylenediamineschemistry.chemical_elementCarbonCombinatorial chemistryStereocenterThe Journal of organic chemistry

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