Search results for "Fluorou"
showing 10 items of 279 documents
Analysis of the Thymidylate Synthase Gene Structure in Colorectal Cancer Patients and lts Possible Relation with the S-Fluorouracil Drug Response
2010
Thymidylate synthase (TS) catalyzes methylation of dUMP to dTMP and it is the target for the 5-Fluorouracil (5-FU) activity*. Barbour et al. showed that variant structural forms of TS in tumour cell lines confer resistance to fluoropyrimidines. We planned to perform the whole TS gene structure by means of sequencing techniques in human colorectal cancer (CRC) san-rples to try to identify the presence of any possible TS variant form that could be responsible of fluoropyrimidines drug resistance and of the worse prognosis. We performed the TS-DNA gene sequence in 68 CRC from patients of A, B, and C Dukes' stages and different histological grade, but we did not find any mutation in the TS-DNA …
An Open-Label Phase II Study Evaluating the Safety and Efficacy of Ramucirumab Combined With mFOLFOX-6 as First-Line Therapy for Metastatic Colorecta…
2014
Abstract Author Summary Background. Vascular endothelial growth factor (VEGF) and VEGF receptor 2 (VEGFR-2) are believed to mediate angiogenesis in colorectal cancer (CRC). Ramucirumab (RAM; IMC-1121B) is a human IgG1 monoclonal antibody that inhibits VEGF ligand binding to VEGFR-2, inhibiting VEGFR-2 activation and signaling. Methods. Patients with metastatic CRC, Eastern Cooperative Oncology Group performance status 0–1, and adequate organ function who had not received chemotherapy for metastatic disease received RAM and the modified FOLFOX-6 regimen every 2 weeks. Endpoints included progression-free survival (PFS), objective response rate, overall survival, and safety. The sample size wa…
Neoadjuvant treatment for locally advanced unresectable and borderline resectable pancreatic cancer: oncological outcomes at a single academic centre.
2020
INTRODUCTION: Pancreatic cancer (PC), even in the absence of metastatic disease, has a dismal prognosis. One-third of them are borderline resectable (BRPC) or locally advanced unresectable PC (LAUPC) at diagnosis. There are limited prospective data supporting the best approach on these tumours. Neoadjuvant chemotherapy (ChT) is being increasingly used in this setting. METHODS: This is a retrospective series of consecutive patients staged as BRPC or LAUPC after discussion in the multidisciplinary board (MDB) at an academic centre. All received neoadjuvant ChT, followed by chemoradiation (ChRT) in some cases, and those achieving enough downstaging had a curative-intent surgery. Descriptive da…
Efficacy of four cleaning solutions for the decontamination of selected cytotoxic drugs on the different surfaces of an automated compounding system
2018
The automated aseptic preparation of ready-to-administer antineoplastic drug solutions with robotic systems reduces the risk of occupational exposure. However, the surfaces in the preparation area of the robot are to be cleaned by wiping with an appropriate cleaning solution. The aim of the study was to evaluate the cleaning efficacy of four cleaning solutions on four surface materials installed in the APOTECAchemo robot. Predefined amounts of cisplatin (Cis), 5-fluorouracil (5-FU), and cyclophosphamide (CP) were intentionally spread on test plates made of stainless steel, aluminium, polyoxymethylene, and polycarbonate just as installed in the robotic system APOTECAchemo. After drying, the …
Interaction of 5‐fluorouracil with β‐cyclodextrin: A density functional theory study with dispersion correction
2020
Detailed studies on the stability, interaction, and microstructure of host‐guest complexes in the vacuum of 5‐fluorouracil (5FU) with β‐cyclodextrin (βCD) were performed using B3LYP with the inclusion of Grimme's dispersion correction GD3 term and 6‐31+G(d,p) basis set. Among several studied 1:1 5FU‐βCD complexes, the one placing the keto tautomer of 5FU vertically in the host cavity and forming N‐H···OCD and CO···HOCD hydrogen bonds with hydroxyl groups of the smaller rim of βCD has the highest stability (Eint = −195 kJ/mol). Interestingly, there are no interactions with the inner hydrophobic part of the βCD host cavity. The strength of the intermolecular H‐bonds to the smaller rim of βC…
Synthetic and Biological Applications of Fluorous Reagents as Phase Tags
2011
The search for new and better techniques for the purification of organic compounds has made the recent emergence of fluorous chemistry in the field of organic synthesis possible. Using fluorous reagents as phase tags allows for the access of different synthetic routes, and this has been translated into a time reduction and higher simplicity compared to standard, nonfluorous procedures. The synthesis in fluorous phase of target molecules can be pursued in a parallel or combinatorial manner in order to access chemical libraries with structural and/or stereochemical diversity. The preparation of radiolabeled molecules also benefits from the advantages of fluorous synthesis. Finally, biochemica…
CCDC 1493778: Experimental Crystal Structure Determination
2019
Related Article: Rajendhraprasad Tatikonda, Massimo Cametti, Elina Kalenius, Antonino Famulari, Kari Rissanen, Matti Haukka|2019|Eur.J.Inorg.Chem.|2019|4463|doi:10.1002/ejic.201900579
CCDC 1949029: Experimental Crystal Structure Determination
2020
Related Article: Kalle Kolari, Evgeny Bulatov, Rajendhraprasad Tatikonda, Kia Bertula, Elina Kalenius, Nonappa, Matti Haukka|2020|Soft Matter|16|2795|doi:10.1039/C9SM02186H
Tworzenie kompleksów inkluzyjnych pomiędzy 5-fluorouracylem a β-cyklodekstrynami
2017
Celem przedstawionego opracowania jest omówienie najważniejszych zagadnień dotyczących chemioterapii z użyciem 5-fluorouracylu, jego metabolizmu oraz zagrożenia wynikające z leczenia tym chemioterapeutykiem. Poruszona została również kwestia możliwości ograniczenia toksyczności 5FU, przez zainkludowaniu go we wnętrzu molekuły β-cyklodekstryny. Przedstawiono również najważniejsze wyniki badań teoretycznych w których przedstawiono geometrię kompleksu inkluzyjnego 5FU⎼βCD. Struktura została zoptymalizowana na poziomie teorii funkcjonału gęstości (DFT) z użyciem metody B3LYP/6-31G. Wykazano istnienie przynajmniej jednego wiązania wodorowego pomiędzy grupą aminową 5FU, a grupą hydroksylową powie…
CCDC 1477312: Experimental Crystal Structure Determination
2016
Related Article: Rajendhraprasad Tatikonda, Sandip Bhowmik, Kari Rissanen, Matti Haukka, Massimo Cametti|2016|Dalton Trans.|45|12756|doi:10.1039/C6DT02008A