Search results for "Footprint"
showing 10 items of 121 documents
Regulation of IL-12 p40 Promoter Activity in Primary Human Monocytes: Roles of NF-κB, CCAAT/Enhancer-Binding Protein β, and PU.1 and Identification o…
2001
Abstract Appropriate regulation of IL-12 expression is critical for cell-mediated immune responses. In the present study, we have analyzed the regulation of IL-12 p40 promoter activity in primary human monocytes in vivo. Accordingly, we analyzed the p40 promoter by in vivo footprinting in resting and activated primary human blood CD14+ monocytes. Interestingly, footprints at binding sites for trans-activating proteins such as C/EBP, NF-κB, and ETS were only found upon stimulation with LPS and IFN-γ. In contrast, a footprint over a purine-rich sequence at −155, termed GA-12 (GATA sequence in the IL-12 promoter), was observed in resting, but not activated, cells. Further characterization of t…
Sustainable Development and Technological Impact on CO2 Reducing Conditions in Romania
2015
Climate change is a reality all over the world, and its complexity is increasing. Therefore, sustainability has become a national and international concern, ingrained in many organizational processes. The ability of organizations to respond to sustainability concerns is sometimes hindered by the complexity of integrating sustainability into business models and by the need to rethink their strategic directions. In Romania, sustainable development has become a priority for businesses, but even though companies are showing some concern, there are yet to demonstrate any full commitment (they are mainly concerned with areas such as society and the environment). This paper assesses Romania’s invo…
Mid-region parathyroid hormone-related protein (PTHrP) binds chromatin of MDA-MB231 breast cancer cells and isolated oligonucleotides “in vitro”
2006
We have previously shown that PTHrP(38-94)-amide restrains growth and invasion "in vitro", causes striking toxicity and accelerates death of some breast cancer cell lines, the most responsive being MDA-MB231 whose tumorigenesis was also attenuated "in vivo". PTHrP(38-94)-amide contains the domain implicated in the nuclear import of PTHrP. Although the nucleus was identified as a destination for mid-region PTHrP, evidence for direct DNA-binding capability is lacking to date. Here, we examined the localization of PTHrP(38-94)-amide within MDA-MB231 cells and within metaphase spread preparations and characterized its DNA-binding properties, employing a combination of immunocytochemical, cytoge…
Convolutional Regression Tsetlin Machine: An Interpretable Approach to Convolutional Regression
2021
The Convolutional Tsetlin Machine (CTM), a variant of Tsetlin Machine (TM), represents patterns as straightforward AND-rules, to address the high computational complexity and the lack of interpretability of Convolutional Neural Networks (CNNs). CTM has shown competitive performance on MNIST, Fashion-MNIST, and Kuzushiji-MNIST pattern classification benchmarks, both in terms of accuracy and memory footprint. In this paper, we propose the Convolutional Regression Tsetlin Machine (C-RTM) that extends the CTM to support continuous output problems in image analysis. C-RTM identifies patterns in images using the convolution operation as in the CTM and then maps the identified patterns into a real…
Novel Three-Phase Multi-Level Inverter with Reduced Components
2019
A new multilevel converter topology is proposed in this paper. Low component count and compact design are the main features of the proposed topology. Furthermore, the proposed converter is a capacitor-, inductor-, and diode-free configuration, allowing reducing the converter footprint, increasing the lifetime and simplifying the control strategy. Further, a comparative study is carried out to highlight the merits of the proposed circuit as compared to existing multilevel topologies. Finally, simulation results for the three-level version using different modulation strategies are presented.
Acoustic Detection of Moving Vehicles
2018
This chapter outlines a robust algorithm to detect the arrival of a vehicle of arbitrary type when other noises are present. It is done via analysis of its acoustic signature against an existing database of recorded and processed acoustic signals. To achieve it with minimum number of false alarms, a construction of a training database of acoustic signatures of signals emitted by vehicles using the distribution of the energies among blocks of wavelet packet coefficients (waveband spectra, see Sect. 4.6) is combined with a procedure of random search for a near-optimal footprint (RSNOFP). The number of false alarms in the detection is minimized even under severe conditions such as: signals emi…
Is there such a thing as sustainable physical activity?
2016
- This study aims to assess the prevalence of different modes of commuting to school and work for 10-12year-olds and their parents; to assess the associations with demographic variables (country, sex, parental education and ethnicity) and with weight status in eight European countries. As part of the ENERGY project a cross-sectional survey was conducted in 2010 in which modes of commuting and socio-demographic variables for children (N=7903) and one of their parents (n=6455) were measured by questionnaires. Children's weight and height were objectively measured; parents self-reported their weight and height. Logistic multilevel regression analyses assessed the associations between mode of c…
The impact of space development structure on the level of ecological footprint - Shift share analysis for European Union countries
2022
The impact of the space development structure on the level of the ecological footprint is an important element of the sustainable development policy, determining not only its directions, but also indicating the manner of respecting en- vironmental principles. The aim of the research is to assess the impact of the spatial development structure on the eco- logical footprint level. The considerations are based on the assumption that the spatial development structure is a determinant of the ecological footprint level. The study used the shift share analysis method. Selected European coun- tries were the subject of the research. The research period covered the years 2009–2019. The spatial differ…
Learning-automaton-based online discovery and tracking of spatiotemporal event patterns.
2013
Discovering and tracking of spatiotemporal patterns in noisy sequences of events are difficult tasks that have become increasingly pertinent due to recent advances in ubiquitous computing, such as community-based social networking applications. The core activities for applications of this class include the sharing and notification of events, and the importance and usefulness of these functionalities increase as event sharing expands into larger areas of one's life. Ironically, instead of being helpful, an excessive number of event notifications can quickly render the functionality of event sharing to be obtrusive. Indeed, any notification of events that provides redundant information to the…
Developments and contributions in the study of La Rioja dinosaur footprints (Spain)
2020
In this paper the study of dinosaur tracks of La Rioja, which began in 1970, is presented as an example of knowledge development, achievements, and events occurring around a paleontological resource having strong media impact. Fieldwork, research, and dissemination since the publication of the first scientific works have been accompanied by activities to protect sites and consider them as natural and cultural heritage. Finally it is shown how a paleontological resource has also led to the development of the tourist infrastructure in the area