Search results for "Forced"

showing 10 items of 500 documents

Oral CorticoSteroid sparing with biologics in severe asthma: A remark of the Severe Asthma Network in Italy (SANI)

2020

According to the data derived from several national and international registries, including SANI (Severe Asthma Network Italy), and considering the strong impact that frequent or regular use of oral corticosteroid has on quality of life (QoL) of severe asthmatics, as well as on the costs for managing corticosteroid-related diseases, oral corticosteroid sparing up to withdrawal should be considered a primary outcome in the management of severe asthma. New biologics have clearly demonstrated that this effect is possible, with concomitant reduction in the rate of exacerbations and in symptom control. Then, there is no reason for using so frequently oral corticosteroid before having explored al…

ISAR International Severe Asthma RegistrySHARPPediatricsSevere asthmaSA severe asthmaBiologics Oral corticosteroids Real-life Registr Severe asthmaOmalizumabforced expiratory volume in the 1st secondFood &ampGrading of Recommendations Assessmentchronic rhinosinusitis with nasal polyposisFEV1chemistry.chemical_compound0302 clinical medicineQuality of lifeEMAReal WorldEuropean Medicines AgencyBiologics; Oral corticosteroids; Real-life; Registr; Severe asthmaOral corticosteroidsFDA Food & Drug AdministrationImmunology and Allergy030223 otorhinolaryngologySevere Heterogeneous Asthma Research collaborationmusculoskeletal neural and ocular physiologyReal-lifeCRSwNPOCSsBenralizumabDupilumabCRSwNP chronic rhinosinusitis with nasal polyposisGRADESHARP Severe Heterogeneous Asthma Research collaboration Patient-centredSevere Asthma Network in ItalyFDAmedicine.drugPulmonary and Respiratory Medicinelcsh:Immunologic diseases. Allergymedicine.medical_specialtyDrug AdministrationGINA Global Initiative for AsthmaRW Real WorldImmunologymacromolecular substancesRWSettore MED/10 - Malattie Dell'Apparato RespiratorioBiologicsInternational Severe Asthma RegistryISAR03 medical and health sciencesSADisease registrySARP Severe Asthma Research ProgramPatient-centredmedicineAsthmabusiness.industrySettore MED/09 - MEDICINA INTERNASANI Severe Asthma Network in ItalySANIBiological productmedicine.diseaseOCSs Oral CorticoSteroidsGINASARPSevere Asthma Research ProgramFEV1 forced expiratory volume in the 1st second030228 respiratory systemchemistrynervous systemRegistrEMA European Medicines AgencyDevelopment and EvaluationSevere asthma Biologics Oral corticosteroids Real-life Registrbusinesslcsh:RC581-607Global Initiative for AsthmaMepolizumabGRADE Grading of Recommendations Assessment Development and Evaluation
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The role of small airways in monitoring the response to asthma treatment: what is beyond FEV1?

2009

The definition of asthma has evolved from that of an episodic disease characterized by reversible airways constriction to a chronic inflammatory disease of the airways, with at least partially reversible airway constriction. Increasing evidence supports the notion that small and large airways play a central role in asthma pathophysiology with regard to inflammation, remodeling and symptoms. The contribution of the distal airways to the asthma phenotype carries implications for the delivery of inhaled medications to the appropriate areas of the lung and for the monitoring of the response to asthma treatment. Asthma control is evaluated on the basis of symptoms, lung function and exacerbation…

ImmunologyAnti-Inflammatory AgentsBronchiDiseaseSettore MED/10 - Malattie Dell'Apparato RespiratorioAir trappingAdrenal Cortex HormonesForced Expiratory VolumemedicineHumansImmunology and AllergyRespiratory systemsmall airwayAsthmaLungbusiness.industryRespiratory diseaserespiratory systemasthmamedicine.diseaseRespiratory Function Testsrespiratory tract diseasesTreatment Outcomemedicine.anatomical_structureSpirometryImmunologyBronchoconstrictionmedicine.symptombusinessRespiratory tract
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In-process heat treatments to improve FS-welded butt joints

2008

Friction-stir welding (FSW) is a relatively new but already well known solid-state welding process whose main advantage with respect to fusion welding processes is the possibility to successfully weld light alloys, traditionally considered difficult to weld or unweldable. Despite the good mechanical performances that can be obtained, there exists the possibility to further improve the joints' effectiveness through post-welding heat treatments that are however time and cost-expensive and, therefore, not best suited for industrial applications. In the present paper, the authors report the results of an experimental campaign, developed on FSW of AA7075-T6 aluminum alloy, aimed to investigate t…

In process heat treatmentMaterials scienceFSWMechanical EngineeringMetallurgyComputer Science Applications1707 Computer Vision and Pattern RecognitionWeldingIndustrial and Manufacturing EngineeringComputer Science Applicationslaw.inventionRefrigerantFusion weldingControl and Systems EngineeringlawThermalButt jointMechanical resistanceForced-airSofteningJoint (geology)SoftwareThe International Journal of Advanced Manufacturing Technology
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Empirical Equations for the Direct Definition of Stress–Strain Laws for Fiber-Section-Based Macromodeling of Infilled Frames

2018

Equivalent strut macromodels are largely used to model the influence of infill walls in frame structures due to their simplicity and effectiveness from a computational point of view. Despite these advantages, which are fundamental to carrying out seismic simulation of complex structures, equivalent struts are phenomenological models and therefore have to conventionally account for the influence of really large amounts of geometrical and mechanical variables with a relatively simple inelastic response. Mechanical approaches, generally used to evaluate the force-displacement curve of a strut, are based on hypothesizing the damage mechanism that will occur for an infill-frame system subject to…

Infilled framesComputer science0211 other engineering and technologies020101 civil engineering02 engineering and technologyFiber section; Finite element modeling (FEM); Infilled frames; Masonry; OpenSees; Reinforced concrete; Mechanics of Materials; Mechanical Engineering0201 civil engineeringOpenSeesInfillPoint (geometry)MasonryOpenSee021110 strategic defence & security studiesbusiness.industryFiber (mathematics)OpenSeesMechanical EngineeringStress–strain curveFrame (networking)Structural engineeringFiber sectionFinite element modeling (FEM)MasonryStrength of materialsReinforced concreteSettore ICAR/09 - Tecnica Delle CostruzioniMechanics of MaterialsbusinessInfilled frameJournal of Engineering Mechanics
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Macroelement Model for the Progressive-Collapse Analysis of Infilled Frames

2021

A new multistrut macromodel for the analysis of the progressive-collapse response of infilled reinforced concrete (RC) frames is presented in this paper. The model consists of three struts: two outer infinitely rigid and resistant struts and one inner fiber-section strut. The inclination of the struts as well as the stress-strain response are modulated by two parameters that are obtained by means of analytical correlations provided in the paper. The latter link the geometric and mechanical properties of an infilled frame to the geometric configuration and mechanical response of the equivalent strut model. This confers the model the capability to adapt to consider different collapse configur…

Infilled frames; OpenSees; Progressive collapse; Reinforced concrete; RobustnessInfilled framesbusiness.industryMechanical EngineeringOpenSeesProgressive collapse0211 other engineering and technologies020101 civil engineering02 engineering and technologyBuilding and ConstructionProgressive collapse analysisStructural engineeringReinforced concrete0201 civil engineeringInfilled framesReinforced concreteSettore ICAR/09 - Tecnica Delle CostruzioniMechanics of Materials021105 building & constructionGeneral Materials SciencebusinessRobustnessGeologyCivil and Structural Engineering
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Apparent interfacial shear strength of short-flax-fiber/starch acetate composites

2016

Abstract The paper deals with an indirect industry-friendly method for identification of the interfacial shear strength (IFSS) in a fully bio-based composite. The IFSS of flax fiber/starch acetate is evaluated by a modified Bowyer and Bader method based on an analysis of the stress–strain curve of a short-fiber-reinforced composite in tension. A shear lag model is developed for the tensile stress–strain response of short-fiber-reinforced composites allowing for an elastic-perfectly plastic stress transfer. Composites with different fiber volume fractions and a variable content of plasticizer have been analyzed. The apparent IFSS of flax/starch acetate is within the range of 5.5–20.5 MPa, de…

Interfacial shear strengthMaterials sciencePolymers and PlasticsApparent interfacial shear strengthGeneral Chemical EngineeringComposite numberSheet molding compoundsGreen composites02 engineering and technology010402 general chemistry01 natural sciencesBiomaterialsFlax fiberPlasticizersFlaxYarnUltimate tensile strengthChemical Engineering (all)Composite materialThermoplastic starchchemistry.chemical_classificationFiber volume fractionsFlax fiberElastic perfectly plasticStress–strain curvePlasticizerPolymer021001 nanoscience & nanotechnologyFiber reinforced plasticsReinforcement0104 chemical sciencesFibersStress-strain curvesReinforced plasticsInterfacial shearchemistryShort-fiber-reinforced compositesAdhesiveGreen composite0210 nano-technologyLinenInternational Journal of Adhesion and Adhesives
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Il divieto di lavoro forzato nel diritto internazionale

2019

L'articolo affronta il tema della responsabilità internazionale dello Stato per il lavoro forzato esterto da privati. La domanda centrale che si pone è a quando gli Stati parti di trattati che vietano il lavoro forzato possono essere considerati responsabili, oltre che nei casi in cui ricorrano direttamente al lavoro forzato, anche in relazione a situazioni in cui a farlo siano privati operanti sul loro territorio o in luoghi sottoposti alla loro giurisdizione.

International ResponsibilityForced LabourResponsabilità internazionaleInternational LawDiritto internazionaleLavoro forzatoObblighi positiviSettore IUS/13 - Diritto InternazionalePositive Obligation
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Out-of-Plane Behavior of URM Infill: Accuracy of Available Capacity Models

2022

The aim of this paper is to check the accuracy of analytical capacity models available for the prediction of out-of-plane strength of unreinforced masonry (URM) infill walls. The accuracy of the available models is checked by detailed comparison with the existing experimental results. In doing so, both types of capacity models are evaluated: Type I for the prediction of the strength in the undamaged state, and Type II for the prediction of strength reduction in the in-plane damaged state. Results from the calculations are discussed, and the best among the available models are recommended. Furthermore, the influence of orthotropy of the infill masonry in the out-of-plane capacity predicted b…

Interstorey drift ratio (IDR)Mechanics of MaterialsMechanical EngineeringUnreinforced masonry (URM) infillGeneral Materials ScienceBuilding and ConstructionCapacity models; In-plane (IP) and out-of-plane (OOP) interaction; Interstorey drift ratio (IDR); OOP capacity; Unreinforced masonry (URM) infillCapacity modelsOOP capacityCivil and Structural EngineeringIn-plane (IP) and out-of-plane (OOP) interaction
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Forced monachizations, judicial strategies and noble logic: Sister Anna Maddalena Valdina

2017

In 1640 Anna, the daughter of the prince of Valdina, was forced to live in a convent (for patrimonial reasons) in Palermo along with three sisters. She was seven years old and remained there until 1699. First she asked her father and then her brother to leave the monastic life that she never accepted. Her story is inscribed within the phenomenon of the so-called "forced monachizations ", to which the Council of Trent had tried to remedy for. After the death of her brother, in 1693, now about sixty years old Anna asked the archbishop of Palermo to nullify his religious profession and to return to the lay state. Thus begins a very severe judicial dispute that triggers a violent jurisdictional…

Jurisdictional ConflictsJurisdictional conflictForced MonachizationSettore M-STO/02 - Storia ModernaReform of the female monasterieFamiliar strategieFamiliar Strat- egie
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A quantitative investigation on the thermoelastic effect of CFRP laminates

2009

The thermoelastic effect on CFRP laminates with various lay-ups is investigated. A thick low crimp unidirectional fabric reinforcement is adopted. The measured thermoelastic signal is compared with predictions from two analytical models based on the meso-mechanical bulk properties of the lamina and on assuming a strain witness behaviour of the surface resin rich layer.

Laminates theorySettore ING-IND/14 - Progettazione Meccanica E Costruzione Di MacchineCarbon Fibre Reinforced Plastics Laminates Theory Thermoelastic Stress AnalysisCarbon fibre reinforced plastics; Laminates theory; Thermoelastic stress analysisThermoelastic stress analysisCarbon fibre reinforced plastics
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